Molecular Target Synopsis
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HCK (P08631) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 23/04/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 23/04/2019)


Chains assessed66
Chains with at least one site assessed as druggable using the strict criteria42
Chains with at least one site assessed as druggable using the relaxed criteria51


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
2HK5_A Tyrosine-protein kinase HCK Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.71 68.6 40.2 Yes Yes
2 empty 2.45 63.3 37.3 No No
3 empty 2.17 64.2 22.9 No No
4 empty 2.19 62.2 20.4 No No
5 empty 2.16 68 17 No No
6 empty 1.78 60.8 13.9 No No
7 empty 2.3 69.6 19.3 No No
8 empty 2 70.2 12.1 No No
9 empty 2.57 68.5 9.9 No No
10 empty 2.59 60.1 13.5 No No
3VS0_A Tyrosine-protein kinase HCK Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.04 70.7 58.1 Yes Yes
2 bound 1.88 79.7 35.8 Yes Yes
3 empty 2.29 62.5 24.8 No No
4 empty 2.09 61.8 18.1 No No
5 empty 2.41 68.2 18.4 No No
6 empty 2.56 63.6 23.6 No No
7 empty 2.24 62.8 12.8 No No
8 empty 2.1 75.1 9.7 No No
9 empty 1.92 55.5 12.6 No No
10 empty 2.27 66.9 10.4 No No
2C0T_A Tyrosine-protein kinase HCK Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.76 71.8 64.2 Yes Yes
2 empty 2.32 63.8 21.8 No No
3 empty 2.46 61.4 26.1 No No
4 empty 2.1 63.4 19 No No
5 empty 2.26 69.3 18.4 No No
6 empty 2.29 60.3 19.9 No No
7 empty 2.18 61.1 17.7 No No
8 empty 1.79 55.6 16.5 No No
9 empty 2.59 75.9 11 No No
10 empty 2.49 64.7 13.3 No No
2C0I_B Tyrosine-protein kinase HCK Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.12 70.3 54.5 Yes Yes
2 bound 1.51 78.7 37.9 Yes Yes
3 empty 2.43 73.6 21.5 No No
4 empty 2.07 68.2 16.4 No No
5 empty 2.03 66.1 18.9 No No
6 empty 2.09 65.4 13.7 No No
7 empty 2.31 62.8 16.4 No No
8 empty 2.3 63.4 19.2 No No
9 empty 2.54 63.2 12.7 No No
10 empty 1.96 53.2 14.5 No No
1BU1_B Tyrosine-protein kinase HCK No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.34 62.4 21.5 No No
2 empty 2.29 70.3 7.4 No No
3 empty 2.73 55 11.5 No No
4 empty 2.8 56.3 12.1 No No
5 empty 2.92 63.3 7.9 No No
6 empty 2.45 68.2 7.5 No No
7 empty 2.47 70.3 6.1 No No
8 empty 2.71 68.5 7.4 No No
9 empty 3.02 47.5 8.6 No No
10 empty 2.09 69.9 0 No No
3REA_D Tyrosine-protein kinase HCK No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.45 59.4 16.3 No No
2 empty 1.95 66 15.7 No No
3 empty 2.05 54.8 12.4 No No
4 empty 2.87 59.3 10.3 No No
5 empty 2.97 66.9 7.3 No No
6 empty 2.66 67.4 9.1 No No
7 empty 2.57 63.6 9 No No
8 empty 2.67 70.9 5.5 No No
9 empty 1.56 72.1 5.2 No No
10 empty 2.68 59.6 6.4 No No
3VS6_B Tyrosine-protein kinase HCK Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.14 70.2 60.1 Yes Yes
2 bound 1.69 75.9 39.6 Yes No
3 empty 2.36 66.5 19.8 No No
4 empty 2.29 56.3 18.5 No No
5 empty 2.34 62.5 16.7 No No
6 empty 2.39 63.9 19.8 No No
7 empty 1.87 63.8 15 No No
8 empty 2.18 61.9 18.9 No No
9 empty 2.46 69.5 11.4 No No
10 empty 2.53 64.5 16.6 No No
3VS2_B Tyrosine-protein kinase HCK Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.12 70.8 57.2 Yes Yes
2 bound 1.62 76.9 34.5 Yes No
3 empty 2.24 64.1 27.8 No No
4 empty 2.18 65.5 18.2 No No
5 empty 2.58 60 22.6 No No
6 empty 1.92 61.2 14.9 No No
7 empty 2.24 66.2 15.6 No No
8 empty 1.79 57.4 15 No No
9 empty 2.33 54.8 14.5 No No
10 empty 2.54 69.3 9.9 No No
1AD5_B Tyrosine-protein kinase HCK Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.96 70.8 55.3 Yes Yes
2 bound 1.8 73.7 38 No No
3 empty 2.39 65.3 17.1 No No
4 empty 1.96 60.9 20.5 No No
5 empty 2.5 61.7 17.8 No No
6 empty 1.89 64.5 14.6 No No
7 empty 2.03 65.7 11.7 No No
8 empty 2.03 59.9 13.9 No No
9 empty 2.27 58.9 12.1 No No
10 empty 2.25 53.4 11.8 No No
3VRY_B Tyrosine-protein kinase HCK Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.15 71.1 54.6 Yes Yes
2 bound 1.84 74.6 39.6 No No
3 empty 2.4 64.5 20.1 No No
4 empty 1.99 62.4 18 No No
5 empty 2.19 65.3 15.8 No No
6 empty 2.08 64.1 14.6 No No
7 empty 2.55 61.7 18.9 No No
8 empty 2.47 64.6 18.9 No No
9 empty 2.41 67 11.9 No No
10 empty 2.46 72.1 12.7 No No
4LUD_A Tyrosine-protein kinase HCK Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.2 69.3 50.1 Yes Yes
2 bound 1.83 68.7 36.2 No No
3 empty 2.31 62.5 22 No No
4 empty 2.18 67.6 21.5 No No
5 empty 2.26 63.1 18.5 No No
6 empty 2.1 67.7 14 No No
7 empty 2.03 58.1 17.5 No No
8 empty 2.14 55.4 15.2 No No
9 empty 2.12 55.1 11.2 No No
10 empty 2.36 57 13.2 No No
1BU1_A Tyrosine-protein kinase HCK No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.43 62.2 19.2 No No
2 empty 2.69 68.8 12.3 No No
3 empty 2.78 56.2 8.4 No No
4 empty 2.78 53.5 10.5 No No
5 empty 2.64 62.3 8.7 No No
6 empty 2.71 71.3 6.4 No No
7 empty 2.6 66.4 6.5 No No
8 empty 2.88 53 6 No No
9 empty 2.13 64.4 5.6 No No
10 empty 2.17 58.3 5.1 No No
4HCK_A Tyrosine-protein kinase HCK No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.42 62.1 13.1 No No
2 empty 2.59 66.3 13.7 No No
3 empty 2.55 65.1 9.5 No No
4 empty 2.09 72.5 10.7 No No
5 empty 2.71 67.6 6.8 No No
6 empty 1.63 69.8 7.2 No No
7 empty 2.47 60.2 7.7 No No
8 empty 2.18 62.5 5.7 No No
9 empty 1.27 58.3 6.3 No No
10 empty 2.47 59 5.9 No No
3VRZ_A Tyrosine-protein kinase HCK Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.33 69.6 59.9 Yes Yes
2 bound 1.67 79.2 35.2 Yes Yes
3 empty 2.46 64.6 20.4 No No
4 empty 2.05 63.2 17.4 No No
5 empty 2.46 66.9 20.1 No No
6 empty 2.3 68.2 19.9 No No
7 empty 2.64 62.4 24.8 No No
8 empty 1.83 54.5 14 No No
9 empty 2.24 75.7 9.3 No No
10 empty 2.09 65.3 15 No No
1BU1_E Tyrosine-protein kinase HCK No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.37 65.8 16 No No
2 empty 3.01 70.6 10 No No
3 empty 2.49 58.7 12.6 No No
4 empty 2.75 64 7.6 No No
5 empty 2.56 70 6.4 No No
6 empty 1.45 52 6.7 No No
7 empty 3.25 72.2 6.8 No No
8 empty 3.13 57.6 6.9 No No
9 empty 2.81 73.4 0 No No
5NUH_C Tyrosine-protein kinase HCK Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.44 58.4 24.4 Yes No
2 empty 3.15 60.2 7.9 No No
3 empty 2.77 69.4 6 No No
4 empty 1.88 73 0 No No
5 empty 2.78 53.3 7.1 No No
6 empty 2.65 62.7 5.8 No No
7 empty 2.62 60.3 6 No No
8 empty 2.18 57.1 6.1 No No
9 empty 3.15 89.6 0 Yes No
3VS4_A Tyrosine-protein kinase HCK Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.04 68.9 64.1 Yes Yes
2 bound 1.9 76.8 35.1 No No
3 empty 2.3 68.7 17 No No
4 empty 2.35 63.5 18 No No
5 empty 2.53 60.6 21.2 No No
6 empty 1.85 59.6 15.9 No No
7 empty 2.47 64.4 13.7 No No
8 empty 2.02 67.5 14.4 No No
9 empty 2.35 63.4 12.2 No No
10 empty 1.95 63.5 9.2 No No
1QCF_A Tyrosine-protein kinase HCK Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.27 69.9 62.9 Yes Yes
2 bound 1.81 70.5 48.7 No No
3 empty 2.34 62.5 26.9 No No
4 empty 2.32 68.1 16.6 No No
5 empty 2.58 60.3 23.1 No No
6 empty 2.11 52.3 15.1 No No
7 empty 1.88 61.7 20.4 No No
8 empty 2.28 63.6 10 No No
9 empty 2.39 54 14.3 No No
10 empty 1.32 68.3 9.8 No No
3RBB_B Tyrosine-protein kinase HCK No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.23 62 16.4 No No
2 empty 3.02 57.9 11.8 No No
3 empty 1.71 62.7 12.4 No No
4 empty 2.66 64.5 8.7 No No
5 empty 2.51 61.4 7.3 No No
6 empty 2.41 62.8 11.2 No No
7 empty 2.55 51.9 8.3 No No
8 empty 2.7 59.8 6.8 No No
9 empty 3.08 61.7 5.9 No No
3VS5_B Tyrosine-protein kinase HCK Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.29 70.2 59.8 Yes Yes
2 bound 1.71 74 38.2 Yes No
3 empty 2.41 67.8 18.2 No No
4 empty 2.59 62.6 24.4 No No
5 empty 1.99 61.9 13.5 No No
6 empty 2.47 54.6 14.3 No No
7 empty 2.21 62.6 18.5 No No
8 empty 2.41 65.7 18.4 No No
9 empty 1.87 47.2 12.4 No No
10 empty 1.73 71.1 14 No No
3VRZ_B Tyrosine-protein kinase HCK Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.45 70.5 61.7 Yes Yes
2 bound 1.78 78.5 36 No No
3 empty 2.65 59.5 25.7 No No
4 empty 2.48 68.7 20.5 No No
5 empty 2.2 64.7 18.4 No No
6 empty 1.98 62.8 18.1 No No
7 empty 2.19 67.9 12.7 No No
8 empty 2.12 55 13.7 No No
9 empty 2.19 67 14.1 No No
10 empty 2.11 58.9 11 No No
4ORZ_A Tyrosine-protein kinase HCK No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.18 67.9 15.5 No No
2 empty 1.43 59.5 7.9 No No
3 empty 2.23 56.8 8.2 No No
4 empty 2.51 68 8.7 No No
5 empty 2.58 78.4 0 No No
6 empty 2.99 60.7 9.8 No No
7 empty 2.83 69.6 6.5 No No
8 empty 2.76 57 7 No No
2OI3_A Tyrosine-protein kinase HCK Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.58 59.3 27.7 Yes No
2 empty 2.36 57.3 18.6 No No
3 empty 2.69 58.2 13.8 No No
4 empty 2.41 65.7 14.5 No No
5 empty 2.42 48.2 10.2 No No
6 empty 2.62 50.2 12.7 No No
7 empty 2.3 61 13 No No
8 empty 2.64 65.7 8.5 No No
9 empty 2.78 64.4 7.4 No No
10 empty 2.6 65.3 6.6 No No
3REA_B Tyrosine-protein kinase HCK No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.96 61.8 17.1 No No
2 empty 2.08 57.1 11.8 No No
3 empty 2.89 61.9 12.3 No No
4 empty 2.44 58.5 11.1 No No
5 empty 2.65 63.1 6.9 No No
6 empty 2.62 68.5 0 No No
7 empty 2.86 69.6 6.1 No No
8 empty 2.81 64 7 No No
9 empty 3.19 66.7 6.3 No No
10 empty 2.92 59.4 4.7 No No
1AD5_A Tyrosine-protein kinase HCK Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.13 71.5 54.3 Yes Yes
2 bound 1.85 69.1 39.2 No No
3 bound 2.27 72 15.6 No No
4 empty 2.36 63.9 17.5 No No
5 empty 1.8 56.9 19.7 No No
6 empty 1.83 56.8 18.3 No No
7 empty 1.79 52.4 18.4 No No
8 empty 2.34 66.7 10.3 No No
9 empty 2.11 54.7 11.4 No No
10 empty 1.98 62 13.1 No No
3VRY_A Tyrosine-protein kinase HCK Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2 68.9 57.7 Yes Yes
2 bound 1.78 76.5 36.5 No No
3 empty 2.31 65 20 No No
4 empty 2.25 63.8 20.5 No No
5 empty 2.17 65.8 19.5 No No
6 empty 2.53 63.8 20.3 No No
7 empty 1.95 50 14.8 No No
8 empty 2.25 71.8 7.1 No No
9 empty 2.41 62.6 12.9 No No
10 empty 2.18 76.3 9.7 No No
1BU1_C Tyrosine-protein kinase HCK No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.58 61.9 23.6 No No
2 empty 2.41 60.9 8.8 No No
3 empty 2.46 63.2 4.8 No No
4 empty 2.12 61 5.5 No No
5 empty 2.25 71 4.2 No No
2HCK_B Tyrosine-protein kinase HCK Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.97 69.8 54.6 Yes Yes
2 bound 1.85 73.1 40.6 No No
3 empty 2.4 69.5 16.8 No No
4 empty 1.82 62.5 25.2 No No
5 empty 2.25 57.5 23.4 No No
6 empty 2.22 56.8 17 No No
7 empty 1.91 61.1 16.8 No No
8 empty 1.86 61 13 No No
9 empty 2.48 63.9 15.4 No No
10 empty 2.14 55.3 11.6 No No
4U5W_B Tyrosine-protein kinase HCK Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.05 65.2 31.3 Yes No
2 empty 2.33 62.3 20.3 No No
3 empty 2.43 65.8 19.6 No No
4 empty 2.15 53.9 16.6 No No
5 empty 1.65 60.4 12.5 No No
6 empty 2.47 60 13.2 No No
7 empty 2.6 57.3 10.8 No No
8 empty 2.16 51.2 11.3 No No
9 empty 2.41 62 9.2 No No
10 empty 2.21 56.6 11.4 No No
4LUD_B Tyrosine-protein kinase HCK Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.3 70.6 49.2 Yes Yes
2 bound 1.91 71.1 37.6 No No
3 empty 2.1 64.7 23.6 No No
4 empty 2.13 57.9 19 No No
5 empty 2.21 67.3 13.7 No No
6 empty 2.3 55.4 21 No No
7 empty 1.88 63.2 19.4 No No
8 empty 1.79 60.4 16.7 No No
9 empty 2.17 62.1 13.7 No No
10 empty 2 61 14.4 No No
5H0G_A Tyrosine-protein kinase HCK Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.1 70.6 64 Yes Yes
2 bound 1.81 78 36 No No
3 empty 2.28 65.4 21.6 No No
4 empty 2.17 64 21.8 No No
5 empty 2.63 62.9 21.5 No No
6 empty 2.7 68.4 14.9 No No
7 empty 2.17 60.2 17.6 No No
8 empty 2.17 57.4 14.2 No No
9 empty 2.3 55.1 16.4 No No
10 empty 2.55 81.4 10.4 No No
3VS7_A Tyrosine-protein kinase HCK Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.12 70.6 53.1 Yes Yes
2 bound 1.72 78 32.2 Yes No
3 empty 2.26 65 19.4 No No
4 empty 2.21 58.9 15.1 No No
5 empty 1.88 65.7 13.4 No No
6 empty 2.32 61.3 19.9 No No
7 empty 1.84 71.7 15.4 No No
8 empty 2.34 58.4 19.2 No No
9 empty 1.97 60.4 11.3 No No
10 empty 2.56 70.7 10.1 No No
1BU1_F Tyrosine-protein kinase HCK No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.41 60.2 22.6 No No
2 empty 2.54 60.8 7.7 No No
3 empty 2.11 67.1 6.7 No No
4 empty 2.96 65.2 11.1 No No
5 empty 2.91 63.4 7.1 No No
6 empty 2.3 61.6 5.9 No No
7 empty 2.84 62 6.2 No No
2C0T_B Tyrosine-protein kinase HCK Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.34 71.1 49.6 Yes Yes
2 bound 1.37 76 34.7 Yes No
3 empty 2.08 55.8 17.4 No No
4 empty 2.07 65.8 14 No No
5 bound 2.56 65.6 17 No No
6 empty 2.16 56 21.5 No No
7 empty 2.63 48.1 18.4 No No
8 empty 2.18 55.7 14.9 No No
9 empty 1.99 61.4 16.2 No No
10 empty 1.89 55.8 14.8 No No
5ZJ6_B Tyrosine-protein kinase HCK Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.57 75.7 35.9 Yes Yes
2 empty 2.18 66.5 22.8 No No
3 empty 2.25 66.7 23.5 No No
4 empty 2.08 58.8 21.4 No No
5 empty 2.57 66.2 21.4 No No
6 empty 2.4 62.9 20.6 No No
7 empty 2.38 64.2 14.1 No No
8 empty 2.46 69.4 11.4 No No
9 empty 2.18 62.6 10.2 No No
10 empty 2.35 73.4 9.9 No No
2HCK_A Tyrosine-protein kinase HCK Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.04 71.7 56.2 Yes Yes
2 bound 1.93 73.9 40.4 No No
3 empty 1.95 60.9 32.8 No No
4 empty 2.22 65.1 18.9 No No
5 empty 2.08 59.6 19.7 No No
6 empty 1.89 61.1 15.2 No No
7 empty 2.17 66.1 13 No No
8 empty 2.43 59.1 22.6 No No
9 empty 2.26 48.4 12.8 No No
10 empty 1.52 98.7 0 Yes No
2OJ2_A Tyrosine-protein kinase HCK Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.61 55.9 25.8 Yes No
2 empty 2.11 47.5 13.5 No No
3 empty 2.7 59.5 10.1 No No
4 empty 2.55 64.8 13.1 No No
5 empty 2.74 67.1 10.3 No No
6 empty 2.5 63.1 7.3 No No
7 empty 3.03 50 7 No No
8 empty 2.9 51.2 7.4 No No
9 empty 2.86 61 6.3 No No
10 empty 2.32 58.8 6.4 No No
5H0H_A Tyrosine-protein kinase HCK Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.19 72.3 52.2 Yes Yes
2 bound 1.85 75.3 37.8 No No
3 empty 1.93 68.1 21.1 No No
4 empty 2.35 63.2 21.9 No No
5 empty 2.44 60.2 21.6 No No
6 empty 2.27 60.2 20.9 No No
7 empty 2.42 61.7 20.2 No No
8 empty 2.19 63.5 13.9 No No
9 empty 1.97 58.5 13.3 No No
10 empty 2.68 67.8 15.8 No No
3VS5_A Tyrosine-protein kinase HCK Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.21 69.9 59.8 Yes Yes
2 bound 1.84 73.4 32.7 No No
3 empty 2.44 68.1 19.1 No No
4 empty 2.51 66.3 22.5 No No
5 empty 2.47 70.4 19.2 No No
6 empty 2.22 61.1 19.9 No No
7 empty 2.35 59.3 13.6 No No
8 empty 1.88 55.6 13.4 No No
9 empty 2.25 62.4 13.1 No No
10 empty 2.03 73.3 10.5 No No
5NUH_D Tyrosine-protein kinase HCK Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.43 59.2 24.3 Yes No
2 empty 2.68 60.6 8.6 No No
3 empty 1.88 72.9 5 No No
4 empty 2.54 64.7 5.9 No No
5 empty 2.29 57.3 6.6 No No
6 empty 3 75.5 5.1 No No
7 empty 2.86 67 5.7 No No
8 empty 2.51 63.6 6.3 No No
9 empty 2.2 56.3 5.2 No No
10 empty 2.86 70.9 4.4 No No
3RBB_D Tyrosine-protein kinase HCK No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.22 59.7 22.8 No No
2 empty 2.55 58.9 13.3 No No
3 empty 2.79 61.2 11.6 No No
4 empty 1.73 59.3 10.2 No No
5 empty 3.24 59.4 9.7 No No
6 empty 2.46 63.3 8.9 No No
7 empty 2.78 75.4 5.5 No No
8 empty 2.47 73.7 0 No No
9 empty 2.62 67.6 7.5 No No
10 empty 3.93 65.6 0 No No
3VS1_B Tyrosine-protein kinase HCK Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.29 69.9 63.7 Yes Yes
2 bound 1.65 78.5 31.6 Yes No
3 empty 1.9 68.9 22.6 No No
4 empty 2.49 62.2 22.2 No No
5 empty 2.35 75.5 15.2 No No
6 empty 1.85 53.8 17.2 No No
7 empty 2 65.2 14.7 No No
8 empty 2.37 59.9 13.7 No No
9 empty 2.22 76 7.8 No No
10 empty 2.24 66.2 11 No No
2C0O_B Tyrosine-protein kinase HCK Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.24 71.3 54.8 Yes Yes
2 bound 1.72 76.9 38 Yes No
3 empty 2.49 70.8 21.3 No No
4 empty 2.36 63.8 19.6 No No
5 empty 2.1 62.8 18.3 No No
6 empty 1.88 68.4 16.4 No No
7 empty 2.36 67.3 13.1 No No
8 empty 1.94 62.1 14 No No
9 empty 2.31 62.2 19.1 No No
10 empty 1.8 54.6 14.1 No No
3VS3_A Tyrosine-protein kinase HCK Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.36 70.1 64.5 Yes Yes
2 bound 1.65 76.2 37.5 Yes No
3 empty 1.87 64.2 22.3 No No
4 empty 2.56 63.3 22.7 No No
5 empty 1.96 66.5 15 No No
6 empty 2.21 66.7 16.6 No No
7 empty 2.54 63.5 15.1 No No
8 empty 1.95 52 12.1 No No
9 empty 1.91 68.7 7.1 No No
10 empty 1.98 99.5 0 Yes No
3VS4_B Tyrosine-protein kinase HCK Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.17 69.8 56.4 Yes Yes
2 bound 1.72 75.8 36.8 Yes No
3 empty 2.39 66.6 18.4 No No
4 empty 2.45 61.1 23.7 No No
5 empty 2.23 62.9 14.9 No No
6 empty 1.98 60.6 15.1 No No
7 empty 1.88 54.9 13.4 No No
8 empty 2.36 66.7 15.4 No No
9 empty 2.47 64.9 9.7 No No
10 empty 2.38 73.6 9.3 No No
3REB_B Tyrosine-protein kinase HCK No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.04 61.5 18.6 No No
2 empty 2.05 53.5 11.9 No No
3 empty 2.98 61.2 13.2 No No
4 empty 2.43 62.3 9.7 No No
5 empty 2.7 57.1 8.5 No No
6 empty 2.63 70.8 5.6 No No
7 empty 2.8 73.2 6.9 No No
8 empty 2.89 65.5 6.2 No No
9 empty 2.93 58.2 6.4 No No
10 empty 2.77 67.2 5 No No
3VS6_A Tyrosine-protein kinase HCK Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.31 69.5 61.5 Yes Yes
2 bound 1.7 72.7 39.5 Yes No
3 empty 2.17 64.6 17.7 No No
4 empty 2.68 61 25.4 No No
5 empty 1.99 60.5 14.8 No No
6 empty 2.55 73.6 17.5 No No
7 empty 1.96 52.3 12.4 No No
8 empty 1.93 62 10.5 No No
9 empty 2.88 71.6 8 No No
10 empty 2.47 62.8 16 No No
3NHN_A Tyrosine-protein kinase HCK Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.01 57.1 25.5 Yes No
2 empty 2.21 59.8 25.8 No No
3 empty 2.69 55.8 23.5 No No
4 empty 2.21 60.3 20.6 No No
5 empty 2.18 67.8 12.7 No No
6 empty 2.11 63.4 10.6 No No
7 empty 2.34 57.8 12.1 No No
8 empty 2.05 56 8.4 No No
9 empty 1.87 55.6 8.6 No No
10 empty 2.81 64.3 7.9 No No
5H0B_A Tyrosine-protein kinase HCK Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.3 72.8 53.4 Yes Yes
2 bound 1.95 75.5 38.7 No No
3 empty 2.05 64.8 20.4 No No
4 empty 2.31 66.4 21.2 No No
5 empty 2.1 60.1 22.9 No No
6 empty 2.18 61.7 21.1 No No
7 empty 2.29 59.7 21.3 No No
8 empty 2.1 59.4 17.5 No No
9 empty 2.41 73.7 10.1 No No
10 empty 2.23 57.4 17.3 No No
3VS3_B Tyrosine-protein kinase HCK Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.17 69.2 62.8 Yes Yes
2 bound 1.75 75.1 37.6 No No
3 empty 2.29 63.8 26.6 No No
4 empty 2.51 62.8 17.5 No No
5 empty 2.59 61.7 23.6 No No
6 empty 1.79 60.1 15.7 No No
7 empty 2.36 60.4 12.9 No No
8 empty 1.93 70.5 10.3 No No
9 empty 1.83 56.3 10.5 No No
10 empty 2.19 64.2 10.2 No No
4LUE_B Tyrosine-protein kinase HCK Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.28 69.7 58.5 Yes Yes
2 bound 1.83 69.2 40.3 No No
3 empty 2.07 68.3 27.8 No No
4 empty 1.7 69.1 18.1 No No
5 empty 2.22 72.8 14.8 No No
6 empty 1.89 55.6 15.4 No No
7 empty 2.1 65.4 15.7 No No
8 empty 2.39 62.1 17.1 No No
9 empty 2 56.8 15.7 No No
10 empty 2.3 62.1 11.4 No No
5H0E_A Tyrosine-protein kinase HCK Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.27 73.6 55.6 Yes Yes
2 bound 1.88 77.5 36.8 No No
3 empty 1.97 68.7 19.5 No No
4 empty 2.25 67.2 21 No No
5 empty 2.18 60 22.8 No No
6 empty 2.45 59.8 18 No No
7 empty 2.52 63.6 20.4 No No
8 empty 2.47 59.4 14 No No
9 empty 1.69 60 16.3 No No
10 empty 2.19 60.2 17.7 No No
3HCK_A Tyrosine-protein kinase HCK Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.3 57.9 29.8 Yes No
2 empty 2.53 56.1 28.2 No No
3 empty 2.2 62 20.3 No No
4 empty 2.56 64.1 18.9 No No
5 empty 2.42 51.5 13.2 No No
6 empty 1.92 60.7 8.2 No No
7 empty 2.71 66 12.1 No No
8 empty 2.26 64.6 10.3 No No
9 empty 2.51 57.1 15 No No
10 empty 1.99 58 8.1 No No
3VS7_B Tyrosine-protein kinase HCK Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.07 71.5 60.2 Yes Yes
2 bound 1.78 75.2 36.4 No No
3 empty 2.17 67 19.4 No No
4 empty 2.26 66.4 18.5 No No
5 empty 2.06 64.9 19.1 No No
6 empty 2.47 59.6 26.7 No No
7 empty 2.38 67.5 19.6 No No
8 empty 2.08 52.7 11.5 No No
9 empty 1.96 72.1 9.9 No No
10 empty 2.21 67.3 10.1 No No
5H09_A Tyrosine-protein kinase HCK Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.14 70.8 61.8 Yes Yes
2 bound 1.91 77.6 36.6 No No
3 empty 2.32 67.2 20 No No
4 empty 2.27 62.5 21.1 No No
5 empty 2.16 62.1 15.3 No No
6 empty 2.36 61.9 14.3 No No
7 empty 2.35 59.9 16.5 No No
8 empty 2.3 56.4 16.3 No No
9 empty 2.41 76.7 9.9 No No
10 empty 1.96 53.6 14.2 No No
5HCK_A Tyrosine-protein kinase HCK No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.49 62.5 20.4 No No
2 empty 2.33 68.7 18.8 No No
3 empty 2.65 63.9 8.8 No No
4 empty 2.03 72.8 8 No No
5 empty 1.78 53.8 9.4 No No
6 empty 2.52 66.9 8.3 No No
7 empty 2.3 56.5 7.1 No No
2C0O_A Tyrosine-protein kinase HCK Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.18 69.9 56.9 Yes Yes
2 bound 1.87 76.5 35 No No
3 empty 2.31 65.8 17.4 No No
4 empty 2.36 59.9 21.7 No No
5 empty 2.22 65.4 17.5 No No
6 empty 2.63 63.6 20.7 No No
7 empty 1.81 67.1 13.7 No No
8 empty 2.31 72.2 12.2 No No
9 empty 2.19 64.7 14.3 No No
10 empty 2.46 64.6 10.9 No No
3VS1_A Tyrosine-protein kinase HCK Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.07 69.3 60.5 Yes Yes
2 bound 1.68 75.4 35.2 Yes No
3 empty 2.31 66.1 18.3 No No
4 empty 2.69 63.3 25.1 No No
5 empty 1.61 67.4 14.8 No No
6 empty 1.87 59.9 16.7 No No
7 empty 2.42 64 15 No No
8 empty 2.53 64.4 13.2 No No
9 empty 2.19 73.9 7.6 No No
10 empty 2.35 62.3 14.3 No No
3VS0_B Tyrosine-protein kinase HCK Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.18 71.2 53.4 Yes Yes
2 bound 1.68 77.4 36.6 Yes No
3 empty 2.53 63.7 29 No No
4 empty 2.45 60.7 24.8 No No
5 empty 2.22 66.5 20.3 No No
6 empty 1.78 62.9 14.8 No No
7 empty 2.37 62.9 12.8 No No
8 empty 2.11 74.5 9.1 No No
9 empty 1.84 100 0 Yes No
10 empty 2.06 63.1 9.1 No No
2C0I_A Tyrosine-protein kinase HCK Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.87 72.6 60.6 Yes Yes
2 empty 2.44 66.8 17.9 No No
3 empty 2.29 61.6 20.4 No No
4 empty 2.09 62.2 16.6 No No
5 empty 2.41 62.4 19.2 No No
6 empty 1.81 67 17.6 No No
7 empty 2.51 62.9 17.5 No No
8 empty 2.56 60.8 19.7 No No
9 empty 2.45 70.6 12.3 No No
10 empty 2.05 47 14.9 No No
3REB_D Tyrosine-protein kinase HCK No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.03 60.4 18.4 No No
2 empty 2.06 54.7 12.5 No No
3 empty 2.49 60.5 7.6 No No
4 empty 2.69 68.5 6.3 No No
5 empty 2.39 68.5 6.1 No No
6 empty 2.77 62.8 5.9 No No
7 empty 2.85 72.5 7.1 No No
8 empty 2.95 72.1 4.2 No No
9 empty 2.04 77.1 0 No No
10 empty 2.5 58.8 6.2 No No
3VS2_A Tyrosine-protein kinase HCK Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.12 69.5 49.4 Yes Yes
2 bound 1.79 73.8 32.3 No No
3 empty 2.18 63.6 23.3 No No
4 empty 2.46 54.4 19.5 No No
5 bound 2.28 73.9 12.5 No No
6 empty 2.21 57.7 19.6 No No
7 empty 2.21 57.8 16.7 No No
8 empty 1.82 62.7 14.6 No No
9 empty 1.92 58.1 14.3 No No
10 empty 1.84 47.3 14 No No
5ZJ6_A Tyrosine-protein kinase HCK Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.65 77.3 35.6 Yes No
2 empty 2.21 67.4 28 No No
3 empty 2.25 66.7 22.6 No No
4 empty 2.33 66.6 17.8 No No
5 empty 2.09 59.8 19.3 No No
6 empty 2.32 65.3 17 No No
7 empty 2.36 67.4 8.7 No No
8 empty 2.4 69.2 10.1 No No
9 empty 2.41 68.3 9.5 No No
10 empty 2.87 72.1 12.1 No No
4LUE_A Tyrosine-protein kinase HCK Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.22 70.5 50.2 Yes Yes
2 bound 1.76 70.3 37.3 No No
3 empty 2.19 64.8 20.2 No No
4 empty 1.87 56.9 16.1 No No
5 empty 1.89 77 12.3 No No
6 empty 2.03 53.5 16.8 No No
7 empty 2.58 72.7 11.4 No No
8 empty 1.9 64.6 16 No No
9 empty 2.04 51.3 16 No No
10 empty 2.11 61 14.3 No No
1BU1_D Tyrosine-protein kinase HCK No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.46 61.9 22.6 No No
2 empty 2.17 66.9 6.5 No No
3 empty 2.98 60.8 8.3 No No
4 empty 2.69 75.2 7.2 No No
5 empty 2.93 73.3 4.6 No No
6 empty 2.44 62 4.9 No No
7 empty 3.24 73.8 0 No No
8 empty 2.38 68.2 5.2 No No
9 empty 2.89 43.5 5.6 No No
10 empty 3.29 67.7 5.5 No No
4U5W_D Tyrosine-protein kinase HCK Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.83 62.7 26.6 Yes No
2 empty 2.53 59 24 No No
3 empty 1.84 62 19.5 No No
4 empty 2.38 62.3 14.5 No No
5 empty 2.48 57.9 11.9 No No
6 empty 2.03 51.6 10.3 No No
7 empty 2.42 68.2 7.1 No No
8 empty 1.96 64.5 6.5 No No
9 empty 2.9 50.3 9.3 No No
10 empty 2.23 57.6 8.5 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed39
Domains assessed as druggable using the strict criteria10
Domains assessed as druggable using the relaxed criteria15

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
1AD5_A (40491) Tyrosine-protein kinase HCK SH2-like, SH2 domain, SH2 domain 2.6Å Yes No
1AD5_B (40492) Tyrosine-protein kinase HCK SH2-like, SH2 domain, SH2 domain 2.6Å Yes No
1AD5_B (24506) Tyrosine-protein kinase HCK SH3-like barrel, SH3-domain, SH3-domain 2.6Å No No
1AD5_A (24505) Tyrosine-protein kinase HCK SH3-like barrel, SH3-domain, SH3-domain 2.6Å No No
1AD5_B (41682) Tyrosine-protein kinase HCK Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 2.6Å Yes Yes
1AD5_A (41681) Tyrosine-protein kinase HCK Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 2.6Å Yes Yes
1BU1_F (24504) Tyrosine-protein kinase HCK SH3-like barrel, SH3-domain, SH3-domain 2.6Å No No
1BU1_E (24503) Tyrosine-protein kinase HCK SH3-like barrel, SH3-domain, SH3-domain 2.6Å No No
1BU1_D (24502) Tyrosine-protein kinase HCK SH3-like barrel, SH3-domain, SH3-domain 2.6Å No No
1BU1_C (24501) Tyrosine-protein kinase HCK SH3-like barrel, SH3-domain, SH3-domain 2.6Å No No
1BU1_B (24500) Tyrosine-protein kinase HCK SH3-like barrel, SH3-domain, SH3-domain 2.6Å No No
1BU1_A (24499) Tyrosine-protein kinase HCK SH3-like barrel, SH3-domain, SH3-domain 2.6Å No No
1QCF_A (41680) Tyrosine-protein kinase HCK Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 2Å Yes Yes
1QCF_A (24498) Tyrosine-protein kinase HCK SH3-like barrel, SH3-domain, SH3-domain 2Å No No
1QCF_A (40490) Tyrosine-protein kinase HCK SH2-like, SH2 domain, SH2 domain 2Å No No
2C0I_A (3050591) Tyrosine-protein kinase HCK Protein kinase-like (PK-like), Protein kinase-like (PK-like), UNMATCHED 2.3Å Yes Yes
2C0I_A (3050589) Tyrosine-protein kinase HCK SH3-like barrel, SH3-domain, UNMATCHED 2.3Å No No
2C0I_A (3050590) Tyrosine-protein kinase HCK SH2-like, SH2 domain, UNMATCHED 2.3Å No No
2C0O_A (3050596) Tyrosine-protein kinase HCK SH3-like barrel, SH3-domain, UNMATCHED 2.85Å No No
2C0O_A (3050597) Tyrosine-protein kinase HCK SH2-like, SH2 domain, UNMATCHED 2.85Å No No
2C0O_A (3050598) Tyrosine-protein kinase HCK Protein kinase-like (PK-like), Protein kinase-like (PK-like), UNMATCHED 2.85Å Yes Yes
2C0T_A (3050601) Tyrosine-protein kinase HCK Protein kinase-like (PK-like), Protein kinase-like (PK-like), UNMATCHED 2.14Å Yes Yes
2C0T_A (3050599) Tyrosine-protein kinase HCK SH3-like barrel, SH3-domain, UNMATCHED 2.14Å Yes No
2C0T_A (3050600) Tyrosine-protein kinase HCK SH2-like, SH2 domain, UNMATCHED 2.14Å No No
2HCK_A (40493) Tyrosine-protein kinase HCK SH2-like, SH2 domain, SH2 domain 3Å No No
2HCK_B (40494) Tyrosine-protein kinase HCK SH2-like, SH2 domain, SH2 domain 3Å No No
2HCK_A (41683) Tyrosine-protein kinase HCK Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 3Å Yes Yes
2HCK_A (4127330) Tyrosine-protein kinase HCK Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit (Homo Multimer) 3Å Yes Yes
2HCK_B (24508) Tyrosine-protein kinase HCK SH3-like barrel, SH3-domain, SH3-domain 3Å No No
2HCK_A (24507) Tyrosine-protein kinase HCK SH3-like barrel, SH3-domain, SH3-domain 3Å No No
2HCK_B (4127330) Tyrosine-protein kinase HCK Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit (Homo Multimer) 3Å Yes Yes
2HCK_B (41684) Tyrosine-protein kinase HCK Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 3Å Yes Yes
2HK5_A (136549) Tyrosine-protein kinase HCK Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 2Å Yes Yes
2OI3_A (3160653) Tyrosine-protein kinase HCK SH3-like barrel, SH3-domain, UNMATCHED No No
2OJ2_A (3160681) Tyrosine-protein kinase HCK SH3-like barrel, SH3-domain, UNMATCHED No No
3HCK_A (40495) Tyrosine-protein kinase HCK SH2-like, SH2 domain, SH2 domain Yes No
3NHN_A (3560722) Tyrosine-protein kinase HCK SH2-like, SH2 domain, UNMATCHED 2.61Å Yes No
3NHN_A (3560721) Tyrosine-protein kinase HCK SH3-like barrel, SH3-domain, UNMATCHED 2.61Å No No
4HCK_A (24510) Tyrosine-protein kinase HCK SH3-like barrel, SH3-domain, SH3-domain No No
5HCK_A (24509) Tyrosine-protein kinase HCK SH3-like barrel, SH3-domain, SH3-domain No No
Ligand-based Druggability Score: 1.65
Ligand-based Druggability Score Percentile: 95%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


HCK is involved in 75 interactions in the network.


Druggability
Overall Druggability Percentile: 99.87
Druggability for Cancer Therapeutics: 99.81
Druggability for Other Therapeutics: 94.11
Cancer-Associated
Cancer-associated percentile : 98.85
Network Articulation Point
Is HCK critical for communication in the network?


Detailed Graph Legend:Help