Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

CFH (P08603) - Overview - Molecular Target Synopsis

Protein


CFH, Complement factor H
UniProt P08603

Also Known as CFAH_HUMAN, CFH, HF, HF1, HF2

Glycoprotein that plays an essential role in maintaining a well-balanced immune response by modulating complement activation. Acts as a soluble inhibitor of complement, where its binding to self markers such as glycan structures prevents complement activation and amplification on cell surfaces (PubMed:21285368, PubMed:25402769). Accelerates the decay of the complement alternative pathway (AP) C3 convertase C3bBb, thus preventing local formation of more C3b, the central player of the complement amplification loop (PubMed:19503104). As a cofactor of the serine protease factor I, CFH also regulates proteolytic degradation of already-deposited C3b (PubMed:18252712, PubMed:28671664). In addition, mediates several cellular responses through interaction with specific receptors. For example, interacts with CR3/ITGAM receptor and thereby mediates the adhesion of human neutrophils to different pathogens. In turn, these pathogens are phagocytosed and destroyed (PubMed:9558116, PubMed:20008295). Homodimer (PubMed:18005991, PubMed:19505476). Forms also homooligomers (PubMed:19505476). Interacts with complement protein C3b; this interaction inhibits complement activation (PubMed:16601698, PubMed:19503104, PubMed:20378178, PubMed:21285368, PubMed:28671664). Interacts with complement protein C3d (PubMed:20378178, PubMed:21285368, PubMed:29190743). Interacts with CR3/ITGAM; this interaction mediates adhesion of neutrophils to pathogens leading to pathogen clearance (PubMed:9558116, PubMed:20008295). Interacts with complement factor I (PubMed:28671664).

6ATG
INSIGHTS TO COMPLEMENT FACTOR H RECRUITMENT BY THE BORRELIAL CSPZ PROTEIN AS REVEALED BY STRUCTURAL ANALYSIS
RCSB/PDB
Inspect Structure
See all 3D Structures for CFH

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: CFH is active in the following subcellular-locations: secreted.
GO terms: CFH is active in the following subcellular-locations: blood microparticle, extracellular exosome, extracellular region, extracellular space.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project CFH has gain in 5 cell-lines, loss in 1 cell-lines and no signal in 998 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HS578T, HT29, K_562

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SCC-3, A2780, SNU-1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HSMM, K562

(see details)

3D Structures


For CFH there are:
44 structures (73 chains) solved
4 are solved in complex with at least one small molecule ligand
2 are solved with an approved drug

CFH is solved in complex with the approved drug(s):

BGC/DEXTROSE (4ONT_D, 4ONT_E, 4ONT_F, 4ZH1_E, 4ZH1_F).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


CFH has been screened with 1 compounds (1 bioactivities). (see details)