Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

(P08515) - Overview - Molecular Target Synopsis

Protein


, Glutathione S-transferase class-mu 26 kDa isozyme
Enzyme Classification 2.5.1.18
UniProt P08515

Also Known as GST26_SCHJA

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles., GST isoenzymes appear to play a central role in the parasite detoxification system. Other functions are also suspected including a role in increasing the solubility of haematin in the parasite gut. Homodimer.

6RWD
CRYSTAL STRUCTURE OF SJGST IN COMPLEX WITH GSH AND ELLAGIC ACID AT 1.53 ANGSTROM RESOLUTION
RCSB/PDB
Inspect Structure
See all 3D Structures for

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
218P08515-1

Gene Copy Number Variation


In COSMIC - Cell Lines Project has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For there are:
29 structures (45 chains) solved
21 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


has been screened with compounds ( bioactivities). (see details)