Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

GSTA1 (P08263) - Overview - Molecular Target Synopsis

Protein


GSTA1, Glutathione S-transferase A1
Enzyme Classification 2.5.1.18
UniProt P08263

Also Known as GSTA1_HUMAN, GSTA1

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Homodimer or heterodimer of GSTA1 and GSTA2.

6ATQ
CRYSTAL STRUCTURE OF APO-HGSTA1-1 EXHIBITING A NEW CONFORMATION OF C- TERMINAL HELIX
RCSB/PDB
Inspect Structure
See all 3D Structures for GSTA1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
222ENSG00000243955ENST00000334575ENSP00000335620P08263-1

Sub-cellular localization


UniProt: GSTA1 is active in the following subcellular-locations: cytoplasm.
GO terms: GSTA1 is active in the following subcellular-locations: cytosol, extracellular exosome.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project GSTA1 has gain in 5 cell-lines, loss in 0 cell-lines and no signal in 1000 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MCF7, OVCAR_3, CCRF_CEM

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: DMS 454, OV-90, BEN

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For GSTA1 there are:
33 structures (91 chains) solved
24 are solved in complex with at least one small molecule ligand
2 are solved with an approved drug

GSTA1 is solved in complex with the approved drug(s):

EAA/ETHACRYNIC ACID (1GSE_A, 1GSE_B, 1GSF_A, 1GSF_B, 1GSF_C, 1GSF_D).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


GSTA1 has been screened with 82 compounds (122 bioactivities), 19 compounds have bioactivities that show binding affinity of <= 500nM (29 bioactivities). (see details)