Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RHOC (P08134) - Overview - Molecular Target Synopsis

Protein


RHOC, Rho-related GTP-binding protein RhoC
UniProt P08134

Also Known as RHOC_HUMAN, RHOC, ARH9, ARHC

Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells. Interacts with RTKN (By similarity). Interacts with AKAP13 (PubMed:11546812). Interacts with DIAPH1 (PubMed:15864301). Interacts with PKN2 (PubMed:20974804). Interacts with ROCK1 and ROCK2 (PubMed:8816443). Interacts with ARHGDIA (PubMed:20400958). Interacts with RIPOR1 (PubMed:27807006).

2GCN
CRYSTAL STRUCTURE OF THE HUMAN RHOC-GDP COMPLEX
RCSB/PDB
Inspect Structure
See all 3D Structures for RHOC

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: RHOC is active in the following subcellular-locations: cell membrane, cleavage furrow.
GO terms: RHOC is active in the following subcellular-locations: cell cortex, cell division site, cleavage furrow, cytoplasm, cytosol, extracellular exosome, intracellular membrane-bounded organelle, plasma membrane, stereocilium.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RHOC has gain in 4 cell-lines, loss in 3 cell-lines and no signal in 998 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SNB_75, SK_MEL_2, TK_10

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: TYK-nu.CP-r, WM-115, SK-MEL-24

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HMEC, NHLF

(see details)

3D Structures


For RHOC there are:
4 structures (6 chains) solved
4 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RHOC has been screened with compounds ( bioactivities). (see details)