Molecular Target Synopsis
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Domains and Structures
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IGF1R (P08069) - Domains And Structures - Molecular Target Synopsis

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Structural Sequence Similarity Matches
Domains Covered Gene Name (Uniprot) Solved in Complex with Organism PDB Chain Identity E-Value Resolution Ligands Release Date
Receptor L domain (100%), Furin-like cysteine rich region (100%) (view alignment) INSR (P06213) - HUMAN 2HR7_A 58.81 0 2.3Å P33 NAG BMA MAN FUC 2006-08-15
Receptor L domain (100%), Furin-like cysteine rich region (99%) (view alignment) INSR (P06213) INS (P01308) HUMAN 3W12_E 57.51 4.0E-101 4.3Å NAG BMA MAN 2013-01-09
Protein tyrosine kinase (100%) (view alignment) FGFR1 (P11362) - HUMAN 6C1B_B 41.2 2.0E-63 2Å YY4 2019-01-16
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 4Z55_A 43.97 3.0E-74 1.55Å 4LO 2016-02-03
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 4CLI_A 45.08 2.0E-73 1.94Å 5P8 2014-05-28
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 4F0I_A 41.79 1.0E-64 2.3Å - 2012-09-05
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 2XB7_A 44.75 1.0E-72 2.5Å GUI 2010-07-28
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 6EBW_A 45.08 2.0E-73 2.455Å J3Y 2019-05-01
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 5AAC_A 45.08 4.0E-73 1.63Å VGH 2016-06-08
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 6NSP_A 41.79 2.0E-64 2.31Å L0P 2019-05-22
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 5A9U_A 45.08 4.0E-73 1.59Å 5P8 2016-06-08
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 5HZN_A 100 0 2.2Å 66A MES 2016-04-06
Protein tyrosine kinase (100%) (view alignment) FGFR1 (P11362) - HUMAN 5UQ0_A 41.2 2.0E-63 2.3Å WP1 2017-02-22
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 4CNH_B 45.08 2.0E-73 1.84Å 3U9 2014-05-28
Protein tyrosine kinase (100%) (view alignment) FGFR1 (P11362) - HUMAN 5A4C_A 40.34 1.0E-63 2.09Å XOJ 2015-08-05
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 4FNZ_A 45.08 2.0E-73 2.6Å NZF 2012-08-29
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 6D22_A 41.79 2.0E-64 2.458Å - 2018-05-02
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 6NSS_A 41.89 6.0E-67 1.97Å L0M 2019-05-22
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 4FNW_A 44.75 8.0E-73 1.75Å - 2012-08-29
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 3F5P_L 100 0 2.9Å 741 2008-12-30
Protein tyrosine kinase (100%) (view alignment) FGFR1 (P11362) - HUMAN 6C18_A 41.2 2.0E-63 2.3Å YY5 2019-01-16
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 6CDT_A 45.08 2.0E-73 1.8Å - 2019-02-20
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 2YHV_A 44.82 9.0E-74 1.89Å - 2011-05-18
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 5FTO_A 44.75 1.0E-72 2.21Å YMX 2016-04-06
Protein tyrosine kinase (100%) (view alignment) ROS1 (P08922) - HUMAN 4UXL_A 48.92 4.0E-70 2.21Å 5P8 2015-03-11
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 5FXR_A 100 0 2.4Å 8LN 2016-10-19
Protein tyrosine kinase (100%) (view alignment) INSR (P06213) - HUMAN 3EKK_A 79.6 0 2.1Å GS2 2008-12-23
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 4AOJ_B 41.89 6.0E-67 2.75Å V4Z 2012-08-15
Protein tyrosine kinase (100%) (view alignment) INSR (P06213) Irs2 (P81122) HUMAN 3BU6_A 79.93 0 1.95Å - 2008-02-19
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 3F5P_M 100 0 2.9Å 741 2008-12-30
Receptor L domain (100%), Furin-like cysteine rich region (100%) (view alignment) IGF1R (P08069) - HUMAN 5U8R_A 100 0 3Å NAG MLT 2018-02-28
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 3F5P_G 100 0 2.9Å 741 2008-12-30
Protein tyrosine kinase (100%) (view alignment) FGFR1 (P11362) - HUMAN 6MZQ_B 41.2 2.0E-63 2Å TZ0 2019-01-16
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 3QQU_A 100 0 2.9Å 01P 2011-04-20
Protein tyrosine kinase (100%) (view alignment) FGFR1 (P11362) - HUMAN 4RWI_A 41.55 6.0E-64 2.29Å - 2015-04-15
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 3F5P_B 100 0 2.9Å 741 2008-12-30
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 3F5P_E 100 0 2.9Å 741 2008-12-30
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 4DCE_A 43.97 3.0E-74 2.03Å 0JF 2012-02-08
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 4FOB_A 43.97 3.0E-74 1.9Å 0US 2012-07-11
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 1M7N_B 100 0 2.7Å - 2003-01-07
Receptor L domain (100%), Furin-like cysteine rich region (100%) (view alignment) GCN4 (P03069), INSR (P06213) INS (P01308) HUMAN, BAKER'S YEAST 6HN5_E 53.06 0 3.2Å NAG 2018-11-21
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 1JQH_C 100 0 2.1Å ANP 2002-04-19
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 3LW0_B 100 0 1.79Å CCX 2010-09-29
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 5KMO_A 41.89 4.0E-67 2.67Å 6UM 2016-12-28
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) IRS1 (P35568) HUMAN 1K3A_A 100 0 2.1Å ACP 2001-11-28
Receptor L domain (100%), Furin-like cysteine rich region (99%) (view alignment) INSR (P06213) INS (P01308) HUMAN 3W13_E 57.51 4.0E-101 4.3Å NAG BMA MAN 2013-01-09
Protein tyrosine kinase (100%) (view alignment) FGFR1 (P11362) - HUMAN 3RHX_A 41.2 1.0E-63 2.01Å 3RH 2011-05-04
Protein tyrosine kinase (100%) (view alignment) FGFR1 (P11362) - HUMAN 6C1O_A 41.2 2.0E-63 2.29Å MK9 2019-01-16
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 5KMJ_A 41.89 4.0E-67 2.04Å 6UF 2016-12-28
Receptor L domain (100%), Furin-like cysteine rich region (100%) (view alignment) INSR (P06213) INS (P01318), INS (P01308) HUMAN 6CEB_A 53.17 0 4.7Å NAG BMA FUC 2018-03-14
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 3NW5_A 100 0 2.14Å LGX 2010-07-28
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 4FOC_A 43.97 3.0E-74 1.7Å 0UU 2012-07-11
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 2OJ9_A 100 0 2Å BMI 2007-05-01
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 4ANS_A 44.48 3.0E-73 1.84Å VGH 2013-03-27
Receptor L domain (100%), Furin-like cysteine rich region (100%), Protein tyrosine kinase (100%) (view alignment) INSR (P06213) (A6XGL2) HUMAN 6PXW_A 56.6 0 3.1Å - 2019-09-04
Protein tyrosine kinase (100%) (view alignment) INSR (P06213) - HUMAN 5HHW_A 79.93 0 1.79Å 60O 2016-04-13
Protein tyrosine kinase (100%) (view alignment) INSR (P06213) Irs2 (P81122) HUMAN 3BU3_A 79.93 0 1.65Å - 2008-02-19
Protein tyrosine kinase (100%) (view alignment) INSR (P06213) - HUMAN 3EKN_A 79.6 0 2.2Å GS3 2008-12-30
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 4CMU_A 45.08 2.0E-73 1.68Å IV7 2014-05-28
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 3LCT_A 43.97 3.0E-74 1.89Å ADP 2010-08-04
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 5JFV_A 41.79 3.0E-64 1.59Å 6K1 2017-03-01
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 3F5P_R 100 0 2.9Å 741 2008-12-30
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 5AAA_A 44.75 7.0E-73 1.73Å VGH 2016-06-08
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 4CCU_A 45.08 2.0E-73 1.97Å AWF 2014-01-29
Receptor L domain (100%), Furin-like cysteine rich region (100%) (view alignment) INSR (P06213) - HUMAN 2HR7_B 58.81 0 2.3Å NAG BMA MAN FUC 2006-08-15
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 5HZN_G 100 0 2.2Å 66A MES 2016-04-06
Protein tyrosine kinase (98%) (view alignment) NTRK2 (Q16620) - HUMAN 4ASZ_A 43.66 6.0E-66 1.7Å - 2012-08-22
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 4MKC_A 43.97 3.0E-74 2.01Å 4MK 2014-04-09
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 4JOA_A 43.97 3.0E-74 2.7Å 3DK 2013-07-17
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 6DKW_A 41.79 3.0E-64 2.91Å GXA 2018-07-11
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 6DKB_A 41.89 6.0E-67 2.68Å FKY 2018-07-11
Receptor L domain (100%), Furin-like cysteine rich region (99%) (view alignment) INSR (P06213) INS (P01308) HUMAN 3W11_E 57.51 4.0E-101 3.9Å NAG BMA MAN 2013-01-09
Receptor L domain (100%), Furin-like cysteine rich region (100%) (view alignment) GCN4 (P03069), INSR (P06213) INS (P01308) HUMAN, BAKER'S YEAST 6HN5_F 53.06 0 3.2Å NAG 2018-11-21
Protein tyrosine kinase (100%) (view alignment) FGFR1 (P11362) - HUMAN 5FLF_B 41.55 2.0E-64 2.58Å - 2016-03-30
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 1M7N_A 100 0 2.7Å - 2003-01-07
Protein tyrosine kinase (100%) (view alignment) INSR (P06213) - HUMAN 1GAG_A 79.93 0 2.7Å - 2001-01-17
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 6PL2_A 41.89 6.0E-67 2.59Å OOM 2019-09-04
Protein tyrosine kinase (100%) (view alignment) FGFR1 (P11362) - HUMAN 5FLF_D 41.55 2.0E-64 2.58Å PGE 2016-03-30
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 5KMI_A 41.89 4.0E-67 1.868Å 6UE 2016-12-28
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 5FTQ_A 44.75 1.0E-72 1.7Å U4W 2016-04-06
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 5HZN_H 100 0 2.2Å 66A MES 2016-04-06
Receptor L domain (100%), Furin-like cysteine rich region (99%) (view alignment) INSR (P06213) - HUMAN 5J3H_E 57.51 4.0E-101 3.27Å NAG BMA FUC MAN 2016-06-15
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 4CLJ_A 45.42 1.0E-73 1.66Å 5P8 2014-05-28
Receptor L domain (100%), Furin-like cysteine rich region (100%) (view alignment) GCN4 (P03069), INSR (P06213) - HUMAN, BAKER'S YEAST 6HN4_E 53.06 0 4.2Å - 2018-11-21
Protein tyrosine kinase (99%) (view alignment) NTRK1 (P04629) - HUMAN 5KVT_A 42.55 3.0E-64 2.45Å YMX 2017-12-27
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 4AOJ_C 41.89 6.0E-67 2.75Å V4Z 2012-08-15
Receptor L domain (100%), Furin-like cysteine rich region (100%) (view alignment) INSR (P06213) INS (P01318), INS (P01308) HUMAN 6CE9_A 53.17 0 4.3Å NAG BMA FUC 2018-03-14
Receptor L domain (100%), Furin-like cysteine rich region (100%) (view alignment) INSR (P06213) INS (P01317) HUMAN 5KQV_F 57.53 0 4.4Å NAG FUC 2017-07-19
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 2ZM3_D 100 0 2.27Å 575 2008-06-10
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 4AOJ_A 41.89 6.0E-67 2.75Å V4Z 2012-08-15
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 1P4O_A 100 0 1.5Å - 2003-04-29
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 2YFX_A 45.42 1.0E-73 1.57Å VGH 2011-05-04
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 4CCB_A 45.08 2.0E-73 1.88Å OFG 2014-01-29
Receptor L domain (100%), Furin-like cysteine rich region (99%) (view alignment) INSR (P06213) IGF1 (P05019), IGF1R (P08069) HUMAN 4XSS_E 57.51 4.0E-101 3Å NAG BMA FUC 2015-06-10
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 3LVP_A 100 0 3Å EPE PDR 2010-07-21
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 6NPT_A 41.89 6.0E-67 2.19Å KWY 2019-05-22
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 4CTC_A 45.08 2.0E-73 2.03Å J99 2014-05-28
Protein tyrosine kinase (100%) (view alignment) FGFR1 (P11362) - HUMAN 6C19_B 41.2 2.0E-63 2.12Å YY7 2019-01-16
Protein tyrosine kinase (100%) (view alignment) INSR (P06213) - HUMAN 1IRK_A 79.93 0 2.1Å - 1995-02-27
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 2ZM3_A 100 0 2.27Å 575 2008-06-10
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 6D1Z_A 41.89 6.0E-67 1.87Å FQD FQM 2018-05-02
Protein tyrosine kinase (100%) (view alignment) INSR (P06213) Irs2 (P81122) HUMAN 3BU5_A 79.93 0 2.1Å ATP 2008-02-19
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 5KMN_A 41.89 4.0E-67 2.136Å 6UK 2016-12-28
Protein tyrosine kinase (100%) (view alignment) FGFR1 (P11362) - HUMAN 6C1C_B 41.2 2.0E-63 2.15Å YY6 2019-01-16
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 1JQH_A 100 0 2.1Å ANP 2002-04-19
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 5KZ0_A 45.08 2.0E-73 2.16Å 6YL 2016-08-17
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 4GT5_A 41.79 2.0E-64 2.398Å - 2012-09-26
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 3F5P_T 100 0 2.9Å 741 2008-12-30
Protein tyrosine kinase (100%) (view alignment) INSR (P06213) PTPN1 (P18031) HUMAN 2B4S_D 79.93 0 2.3Å - 2005-11-15
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 5HZN_F 100 0 2.2Å 66A MES 2016-04-06
Protein tyrosine kinase (100%) (view alignment) INSR (P06213) - HUMAN 5E1S_A 79.93 0 2.26Å 5JA 2015-10-14
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 3F5P_D 100 0 2.9Å 741 2008-12-30
Protein tyrosine kinase (100%) (view alignment) FGFR1 (P11362) - HUMAN 6C1O_B 41.2 2.0E-63 2.29Å MK9 2019-01-16
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 4PMT_A 41.79 9.0E-65 2.1Å 31Y 2014-06-18
Protein tyrosine kinase (100%) (view alignment) FGFR1 (P11362) - HUMAN 5AM7_B 41.55 5.0E-64 1.957Å 38O 2015-03-18
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 3F5P_I 100 0 2.9Å 741 2008-12-30
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 3LCS_A 43.97 3.0E-74 1.9Å STU 2010-08-04
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 4CMO_A 45.08 2.0E-73 1.84Å YPW 2014-05-28
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 3QQU_C 100 0 2.9Å 01P 2011-04-20
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 3LW0_D 100 0 1.79Å CCX 2010-09-29
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 5IUI_A 45.08 2.0E-73 1.88Å 45Q 2016-05-18
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 3NW7_A 100 0 2.11Å LGV 2010-07-28
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 4PMM_A 41.79 9.0E-65 2Å 31V 2014-06-18
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 5FXS_A 100 0 1.9Å OZN 2016-10-19
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 4YPS_A 41.79 2.0E-64 2.1Å 4F6 2015-06-03
Protein tyrosine kinase (100%) (view alignment) INSR (P06213) - HUMAN 3ETA_A 80.34 0 2.6Å 351 2009-05-26
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 3LVP_D 100 0 3Å PDR 2010-07-21
Protein tyrosine kinase (100%) (view alignment) INSR (P06213) - HUMAN 1I44_A 79.6 0 2.4Å ACP 2001-03-07
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 6E0R_A 45.08 2.0E-73 2.3Å HKJ 2019-05-01
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 4ANQ_A 44.15 6.0E-73 1.76Å VGH 2013-03-27
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 5H3Q_A 41.89 5.0E-67 2.1Å 7HF 2017-02-22
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 3I81_A 100 0 2.08Å EBI 2009-12-22
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 1JQH_B 100 0 2.1Å ANP 2002-04-19
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 4TT7_A 44.83 1.0E-72 2.1Å COM 2015-02-11
Protein tyrosine kinase (100%) (view alignment) INSR (P06213) - HUMAN 4IBM_A 80.47 0 1.8Å IR1 2013-08-21
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 4F0I_B 41.79 1.0E-64 2.3Å - 2012-09-05
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 3LW0_A 100 0 1.79Å CCX 2010-09-29
Protein tyrosine kinase (100%) (view alignment) FGFR1 (P11362) - HUMAN 4RWI_B 41.55 6.0E-64 2.29Å - 2015-04-15
Protein tyrosine kinase (100%) (view alignment) INSR (P06213) Sh2b2 (Q9Z200) HUMAN 1RQQ_A 79.93 0 2.6Å - 2003-12-30
Receptor L domain (100%), Furin-like cysteine rich region (100%) (view alignment) INSR (P06213) INS (P01317) HUMAN 5KQV_E 57.53 0 4.4Å NAG FUC 2017-07-19
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 4PMP_A 41.79 9.0E-65 1.8Å 31W 2014-06-18
Protein tyrosine kinase (100%) (view alignment) FGFR1 (P11362) - HUMAN 4RWK_A 41.55 6.0E-64 2.98Å 66T 2015-04-15
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 6MX8_A 44.9 8.0E-73 1.96Å 6GY 2018-12-12
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 2XBA_A 44.75 1.0E-72 1.95Å 571 2010-07-28
Receptor L domain (100%), Furin-like cysteine rich region (100%) (view alignment) INSR (P06213) INS (P01318), INS (P01308) HUMAN 6CE7_A 52.38 0 7.4Å - 2018-03-14
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 4DCE_B 43.97 3.0E-74 2.03Å 0JF 2012-02-08
(view alignment) IGF1R (P08069) INSR (P06213), IGF1 (P05019) 4XSS_F 100 0 3Å - 2015-06-10
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 4D2R_A 100 0 2.1Å DYK 2015-04-22
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 5HZN_D 100 0 2.2Å 66A MES 2016-04-06
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 3L9P_A 43.97 3.0E-74 1.8Å - 2010-07-28
Protein tyrosine kinase (100%) (view alignment) FGFR1 (P11362) - HUMAN 5UR1_A 41.2 2.0E-63 2.2Å YY9 2017-05-31
Protein tyrosine kinase (100%) (view alignment) FGFR1 (P11362) - HUMAN 5FLF_E 41.55 2.0E-64 2.58Å - 2016-03-30
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 3F5P_K 100 0 2.9Å 741 2008-12-30
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 5KMK_A 41.89 4.0E-67 2.24Å 6UG 2016-12-28
Protein tyrosine kinase (100%) (view alignment) INSR (P06213) - HUMAN 3ETA_B 80.34 0 2.6Å 351 2009-05-26
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 4CNH_A 45.08 2.0E-73 1.84Å 3U9 2014-05-28
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 4YNE_A 41.79 2.0E-64 2.02Å 4EK 2015-06-03
Protein tyrosine kinase (100%) (view alignment) FGFR1 (P11362) - HUMAN 6C18_B 41.2 2.0E-63 2.3Å YY5 2019-01-16
Protein tyrosine kinase (100%) (view alignment) FGFR1 (P11362) - HUMAN 5A4C_B 40.34 1.0E-63 2.09Å XOJ 2015-08-05
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 5IUG_A 45.08 2.0E-73 1.93Å 729 2016-05-18
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 6DKG_A 41.89 6.0E-67 2.53Å 22L GO7 2018-07-11
Protein tyrosine kinase (100%) (view alignment) INSR (P06213) - HUMAN 4IBM_B 80.47 0 1.8Å IR1 2013-08-21
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 3F5P_H 100 0 2.9Å 741 2008-12-30
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 5AA8_A 44.75 1.0E-72 1.86Å 5P8 2016-06-08
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 5JFW_A 41.79 3.0E-64 1.52Å 6K2 2017-03-01
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 6D1Y_A 41.89 6.0E-67 1.93Å FQJ 2018-05-02
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 3F5P_F 100 0 2.9Å 741 2008-12-30
Protein tyrosine kinase (100%) (view alignment) INSR (P06213) - HUMAN 1IR3_A 79.93 0 1.9Å ANP 1998-01-07
Protein tyrosine kinase (100%) (view alignment) FGFR1 (P11362) - HUMAN 5UQ0_B 41.2 2.0E-63 2.3Å WP1 2017-02-22
Protein tyrosine kinase (100%) (view alignment) INSR (P06213) IRS1 (P35568) HUMAN 2Z8C_A 79.93 0 3.25Å S91 2008-08-12
Protein tyrosine kinase (98%) (view alignment) NTRK2 (Q16620) - HUMAN 4AT5_A 43.66 6.0E-66 1.71Å MUJ 2012-08-22
Receptor L domain (100%), Furin-like cysteine rich region (100%) (view alignment) INSR (P06213) INS (P01318), INS (P01308) HUMAN 6CE7_B 52.38 0 7.4Å - 2018-03-14
Protein tyrosine kinase (98%) (view alignment) NTRK2 (Q16620) - HUMAN 4AT4_A 43.66 6.0E-66 2.36Å T6E 2012-08-22
Protein tyrosine kinase (100%) (view alignment) INSR (P06213) - HUMAN 1P14_A 79.6 0 1.9Å - 2003-07-22
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 6DKI_A 41.89 6.0E-67 2.11Å GOD 22L 2018-07-11
Receptor L domain (100%), Furin-like cysteine rich region (99%) (view alignment) INSR (P06213) Insr (P15127) HUMAN 4XST_E 57.51 4.0E-101 3Å NAG FUC 2015-06-10
Receptor L domain (100%), Furin-like cysteine rich region (100%), Protein tyrosine kinase (100%) (view alignment) INSR (P06213) (A6XGL2) HUMAN 6PXV_A 56.6 0 3.2Å - 2019-09-04
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 5HZN_B 100 0 2.2Å 66A MES 2016-04-06
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 5JFX_A 41.79 3.0E-64 1.63Å 6K4 2017-03-01
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 5IMX_A 45.08 2.0E-73 2.12Å CZ4 2016-05-04
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 5JFS_A 41.79 3.0E-64 1.66Å 6K0 2017-03-01
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 4CMT_A 45.08 2.0E-73 1.73Å GWH 2014-05-28
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 5WR7_A 41.89 5.0E-67 2.76Å RCH 2017-12-06
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 4FNX_A 44.75 6.0E-73 1.7Å - 2012-08-29
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 4PMS_A 41.79 9.0E-65 2.8Å 31X 2014-06-18
Receptor L domain (100%), Furin-like cysteine rich region (100%) (view alignment) INSR (P06213) INS (P01318), INS (P01308) HUMAN 6CEB_B 53.17 0 4.7Å NAG BMA FUC 2018-03-14
Protein tyrosine kinase (100%) (view alignment) FGFR1 (P11362) - HUMAN 6C1C_A 41.2 2.0E-63 2.15Å YY6 2019-01-16
Protein tyrosine kinase (100%) (view alignment) INSR (P06213) - HUMAN 4XLV_A 78.62 0 2.3Å ACP 2015-03-25
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 6PL1_A 41.89 6.0E-67 2.03Å OOJ 2019-10-09
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 6J5L_A 41.79 2.0E-64 2.3Å B9C 2019-07-17
Protein tyrosine kinase (100%) (view alignment) INSR (P06213) GRB14 (Q14449) HUMAN 2AUH_A 79.93 0 3.2Å - 2005-11-01
Protein tyrosine kinase (100%) (view alignment) FGFR1 (P11362) - HUMAN 3RHX_B 41.2 1.0E-63 2.01Å 3RH 2011-05-04
Protein tyrosine kinase (100%) (view alignment) INSR (P06213) PTPN1 (P18031) HUMAN 2B4S_B 79.93 0 2.3Å - 2005-11-15
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 5KMM_A 41.89 4.0E-67 2.117Å 6UJ 2016-12-28
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 3F5P_S 100 0 2.9Å 741 2008-12-30
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 2ZM3_B 100 0 2.27Å 575 2008-06-10
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 3O23_A 100 0 2.1Å MQY 2011-05-04
Receptor L domain (100%), Furin-like cysteine rich region (100%) (view alignment) INSR (P06213) INS (P01318), INS (P01308) HUMAN 6CE9_B 53.17 0 4.3Å NAG BMA FUC 2018-03-14
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 5AAB_A 44.75 1.0E-72 2.2Å VGH 2016-06-08
Protein tyrosine kinase (100%) (view alignment) FGFR1 (P11362) - HUMAN 4WUN_B 41.2 2.0E-63 1.65Å 66T 2014-11-19
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 3LVP_C 100 0 3Å PDR 2010-07-21
Protein tyrosine kinase (100%) (view alignment) FGFR1 (P11362) - HUMAN 6MZQ_A 41.2 2.0E-63 2Å TZ0 2019-01-16
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 3NW6_A 100 0 2.2Å LGW 2010-07-28
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 3AOX_A 43.97 3.0E-74 1.75Å EMH 2011-05-25
Receptor L domain (100%), Furin-like cysteine rich region (100%) (view alignment) IGF1R (P08069) IGF1 (P05019) HUMAN 5U8Q_A 100 0 3.27Å NAG MAN MLT 2018-02-28
Protein tyrosine kinase (98%) (view alignment) NTRK2 (Q16620) - HUMAN 4AT3_A 43.66 6.0E-66 1.77Å LTI 2012-08-22
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 5AA9_A 44.75 7.0E-73 1.77Å 5P8 2016-06-08
Protein tyrosine kinase (100%) (view alignment) FGFR1 (P11362) - HUMAN 6C19_A 41.2 2.0E-63 2.12Å YY7 2019-01-16
Protein tyrosine kinase (100%) (view alignment) FGFR1 (P11362) - HUMAN 5FLF_C 41.55 2.0E-64 2.58Å PGE 2016-03-30
Protein tyrosine kinase (100%) (view alignment) INSR (P06213) Sh2b2 (Q9Z200) HUMAN 1RQQ_B 79.93 0 2.6Å - 2003-12-30
Receptor L domain (100%), Furin-like cysteine rich region (99%) (view alignment) INSR (P06213) INS (P01308) HUMAN 4OGA_E 57.51 4.0E-101 3.5Å NAG BMA MAN FUC 2014-08-27
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 4CD0_A 44.82 9.0E-74 2.23Å AWJ 2014-01-29
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 3D94_A 100 0 2.3Å D94 2008-07-29
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 5KML_A 41.89 4.0E-67 2.01Å 6UH 2016-12-28
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 5FXQ_A 100 0 2.3Å GD5 2016-10-19
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 3LW0_C 100 0 1.79Å CCX 2010-09-29
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 5HZN_C 100 0 2.2Å 66A MES 2016-04-06
Protein tyrosine kinase (100%) (view alignment) ROS1 (P08922) - HUMAN 3ZBF_A 48.92 4.0E-70 2.12Å VGH 2013-06-12
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 3QQU_B 100 0 2.9Å 01P 2011-04-20
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 5HZN_E 100 0 2.2Å 66A MES 2016-04-06
Protein tyrosine kinase (100%) (view alignment) FGFR1 (P11362) - HUMAN 4RWK_B 41.55 6.0E-64 2.98Å 66T 2015-04-15
Receptor L domain (100%), Furin-like cysteine rich region (100%) (view alignment) GCN4 (P03069), INSR (P06213) - HUMAN, BAKER'S YEAST 6HN4_F 53.06 0 4.2Å NAG 2018-11-21
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 4ANL_A 44.15 6.0E-73 1.7Å - 2013-03-27
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 2YJR_A 44.15 9.0E-73 1.8Å - 2012-06-06
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 3F5P_A 100 0 2.9Å 741 2008-12-30
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 6D20_A 41.89 6.0E-67 1.94Å FQG FQD 2018-05-02
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 1P4O_B 100 0 1.5Å - 2003-04-29
Receptor L domain (100%), Furin-like cysteine rich region (100%), Protein tyrosine kinase (100%) (view alignment) INSR (P06213) (A6XGL2) HUMAN 6PXV_C 56.6 0 3.2Å - 2019-09-04
Protein tyrosine kinase (99%) (view alignment) Musk (Q62838) - NORWAY RAT 1LUF_A 43.31 1.0E-67 2.05Å - 2002-09-11
Receptor L domain (100%), Furin-like cysteine rich region (100%) (view alignment) INSR (P06213) - 4ZXB_E 52.74 0 3.3Å NAG BMA FUC MAN 2016-02-24
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 6DKW_B 41.79 3.0E-64 2.91Å GXA 2018-07-11
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 6PL3_A 41.89 6.0E-67 3Å OOD 2019-09-04
Receptor L domain (100%), Furin-like cysteine rich region (100%), Protein tyrosine kinase (100%) (view alignment) INSR (P06213) (A6XGL2) HUMAN 6PXW_B 56.6 0 3.1Å - 2019-09-04
Protein tyrosine kinase (100%) (view alignment) FGFR1 (P11362) - HUMAN 5FLF_A 41.55 2.0E-64 2.58Å - 2016-03-30
Protein tyrosine kinase (100%) (view alignment) FGFR1 (P11362) - HUMAN 5AM7_A 41.55 5.0E-64 1.957Å 38O 2015-03-18
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 3LVP_B 100 0 3Å PDR 2010-07-21
Protein tyrosine kinase (100%) (view alignment) FGFR1 (P11362) - HUMAN 6C1B_A 41.2 2.0E-63 2Å YY4 2019-01-16
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 4FOD_A 43.97 3.0E-74 2Å 0UV 2012-07-11
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 4FNY_A 44.75 6.0E-73 2.45Å I3K 2012-08-29
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 5IUH_A 45.08 2.0E-73 2.1Å 34Y 2016-05-18
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 2YJS_A 44.48 3.0E-73 1.84Å - 2012-06-06
Receptor L domain (100%), Furin-like cysteine rich region (100%) (view alignment) IGF1R (P08069) - HUMAN 1IGR_A 100 0 2.6Å NAG BMA FUC MAN 1999-09-27
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 6EDL_A 45.08 2.0E-73 2.8Å J4M 2019-05-01
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 3F5P_J 100 0 2.9Å 741 2008-12-30
Protein tyrosine kinase (99%) (view alignment) NTRK1 (P04629) - HUMAN 5I8A_A 42.55 2.0E-64 2.33Å 69C 2017-08-09
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 2ZM3_C 100 0 2.27Å 575 2008-06-10
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 4CTB_A 45.08 2.0E-73 1.73Å KVC 2014-05-28
Protein tyrosine kinase (100%) (view alignment) FGFR1 (P11362) - HUMAN 5UR1_B 41.2 2.0E-63 2.2Å YY9 2017-05-31
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 3F5P_C 100 0 2.9Å 741 2008-12-30
Protein tyrosine kinase (100%) (view alignment) IGF1R (P08069) - HUMAN 3QQU_D 100 0 2.9Å 01P 2011-04-20
Protein tyrosine kinase (100%) (view alignment) ALK (Q9UM73) - HUMAN 2XP2_A 45.08 2.0E-73 1.86Å VGH 2010-09-15