Molecular Target Synopsis
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IGF1R (P08069) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 08/10/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 08/10/2019)


Chains assessed62
Chains with at least one site assessed as druggable using the strict criteria42
Chains with at least one site assessed as druggable using the relaxed criteria62


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
5HZN_A Insulin-like growth factor 1 receptor Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.62 70 47 Yes Yes
2 empty 1.98 69.6 41.3 No No
3 empty 2.21 63 31.8 No No
4 empty 2.15 61.5 26.4 No No
5 bound 2.17 68.5 18.2 No No
6 empty 2.46 61.8 18.5 No No
7 empty 1.79 71.2 12.3 No No
8 empty 2.24 66.6 14.1 No No
9 empty 2.25 62.8 14.6 No No
10 empty 1.79 64.2 11 No No
3F5P_L Insulin-like growth factor 1 receptor Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.58 68 40.9 Yes Yes
2 empty 2.11 62 22 No No
3 empty 2.3 66.4 29.5 No No
4 empty 2.12 66.4 29 No No
5 empty 2.36 65.4 25.5 No No
6 empty 2.01 76.8 15.8 No No
7 empty 2.29 64.8 18.6 No No
8 empty 2.03 62.8 16.8 No No
9 empty 2.28 76.3 9.7 No No
10 empty 2.28 71 9 No No
5FXR_A Insulin-like growth factor 1 receptor Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.03 65.7 27.1 Yes No
2 empty 2.02 68 33.1 No No
3 empty 1.79 66.5 31.1 No No
4 empty 2.3 67.9 26.7 No No
5 bound 1.48 79.7 18.3 No No
6 empty 2.15 62.2 20.6 No No
7 empty 2.2 57.1 18.2 No No
8 empty 2.38 65.2 14.9 No No
9 empty 1.87 73.7 10.7 No No
10 empty 2.5 51.2 14.1 No No
3F5P_M Insulin-like growth factor 1 receptor Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.63 67.8 40 Yes Yes
2 empty 2.16 62.6 46.2 No No
3 empty 2.47 67.7 25.7 No No
4 empty 2.35 67.2 30.6 No No
5 empty 1.91 67.8 26.9 No No
6 empty 1.88 71.3 22.2 No No
7 empty 2.16 61.4 23.1 No No
8 empty 2.35 74 12.8 No No
9 empty 2.33 66.6 13.7 No No
10 empty 2.12 57.1 12.2 No No
5U8R_A Insulin-like growth factor 1 receptor Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.52 69 38.6 Yes Yes
2 empty 2.02 62.9 30.4 No No
3 empty 2.34 57.5 31.7 No No
4 bound 2.01 64.5 34.7 No No
5 empty 2.03 62.7 31.8 No No
6 empty 1.99 58.8 31.2 No No
7 empty 2.1 65.7 37 No No
8 empty 2.48 63.2 22.5 No No
9 bound 1.92 57.3 21.9 No No
10 bound 1.82 59.8 20.4 No No
3F5P_G Insulin-like growth factor 1 receptor Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.62 68.5 39.2 Yes Yes
2 empty 2.17 66.3 28.6 No No
3 empty 2.01 67.4 37.7 No No
4 empty 2.36 65.2 32.1 No No
5 empty 2.3 74.7 19.7 No No
6 empty 2 72 13.8 No No
7 empty 2.38 55.2 18.3 No No
8 empty 2.27 79.3 10 No No
9 empty 2.23 63.5 16.1 No No
10 empty 2.31 71.9 8.5 No No
3QQU_A Insulin-like growth factor 1 receptor Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.82 71 45.4 Yes Yes
2 empty 2.26 63.9 30.7 No No
3 empty 1.86 69.9 40.4 No No
4 empty 1.86 61 21.1 No No
5 empty 2.06 62 20.7 No No
6 empty 2.46 67.8 13.4 No No
7 empty 1.75 65.7 11.3 No No
8 empty 2.03 55.6 10.9 No No
9 empty 1.88 72.9 8 No No
10 empty 1.97 65.1 7.1 No No
3F5P_B Insulin-like growth factor 1 receptor Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.69 67.3 40.2 Yes Yes
2 empty 2.18 65.2 41.7 No No
3 empty 2.15 64.7 37.3 No No
4 empty 2.5 65 28 No No
5 empty 2.4 67.1 15 No No
6 empty 2.02 70.8 17.6 No No
7 empty 2.24 67.3 19.4 No No
8 empty 2.27 61 17.1 No No
9 empty 2.31 78.1 12.3 No No
10 empty 2.23 70.8 9.8 No No
3F5P_E Insulin-like growth factor 1 receptor Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.56 69.8 39.2 Yes Yes
2 empty 2.21 64 35.4 No No
3 empty 2.19 63.9 37.4 No No
4 empty 2.39 64 21.8 No No
5 empty 2.22 68.1 23.8 No No
6 empty 1.92 72.9 15.7 No No
7 empty 2.18 73.2 12.1 No No
8 empty 2.19 62.4 15.1 No No
9 empty 1.8 70.4 14.9 No No
10 empty 2.23 55.1 10.9 No No
1M7N_B Insulin-like growth factor 1 receptor Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.53 67.1 46.5 Yes Yes
2 empty 2.16 62.6 41.5 No No
3 empty 2.06 66.7 42.3 No No
4 empty 2.25 60.5 17.8 No No
5 empty 1.93 69.1 14.4 No No
6 empty 2.23 62.2 13.9 No No
7 empty 1.94 70.8 11.9 No No
8 empty 1.93 61 14.1 No No
9 empty 2 64.2 10.3 No No
10 empty 2.12 55 14 No No
1JQH_C Insulin-like growth factor 1 receptor Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.91 75.2 22.6 Yes Yes
2 empty 2.08 62.1 27.8 No No
3 empty 2.08 64.8 18.6 No No
4 empty 2.01 53.5 17.9 No No
5 empty 2.09 62.1 19.6 No No
6 empty 2.2 65.3 13.8 No No
7 empty 1.79 56.5 17.4 No No
8 empty 2.24 62.4 12.5 No No
9 empty 1.82 65.5 12.5 No No
10 empty 1.88 67 10.9 No No
3LW0_B Insulin-like growth factor 1 receptor Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.48 66.9 47.1 Yes Yes
2 empty 2.19 61.5 40.5 No No
3 empty 2.27 65.9 27.5 No No
4 empty 2.1 72.2 19.6 No No
5 bound 1.94 76.5 14.6 No No
6 empty 2.06 63.6 19.8 No No
7 empty 1.96 68 17.3 No No
8 empty 2.31 61.4 13.8 No No
9 empty 2.41 61.3 11.6 No No
10 empty 1.89 56.8 15.7 No No
1K3A_A Insulin-like growth factor 1 receptor Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.89 65 48.2 Yes No
2 empty 2.19 60.9 40.8 No No
3 empty 2.26 64.6 26.9 No No
4 empty 1.98 71 17.6 No No
5 empty 1.8 64 17.1 No No
6 empty 2.28 62.1 11.1 No No
7 empty 1.81 65.4 11.3 No No
8 empty 1.77 61.8 14.6 No No
9 empty 2.04 74.7 7.7 No No
10 empty 2.28 57.5 10.1 No No
3NW5_A Insulin-like growth factor 1 receptor Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.91 71.9 40.3 Yes Yes
2 empty 2.14 65.4 26.6 No No
3 empty 2.29 67.5 27.8 No No
4 empty 1.98 70.2 29.2 No No
5 empty 2.27 65 12.9 No No
6 empty 1.82 66.1 13.6 No No
7 empty 1.91 69.3 8 No No
8 empty 2.51 61.7 17.8 No No
9 empty 1.7 72.6 8.4 No No
10 empty 2.07 61.3 9 No No
2OJ9_A Insulin-like growth factor 1 receptor Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.94 69.1 37 Yes Yes
2 empty 2.24 61.6 27 No No
3 empty 2.03 57.6 29.1 No No
4 empty 2.14 66 23.2 No No
5 empty 2.24 67.2 18.7 No No
6 empty 1.93 76.6 16 No No
7 empty 2.06 69 20.7 No No
8 empty 1.96 54.2 18 No No
9 empty 1.86 70.4 9.3 No No
10 empty 2.56 54.5 13.8 No No
3F5P_R Insulin-like growth factor 1 receptor Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.66 68.2 39.5 Yes Yes
2 empty 2.27 64 37.4 No No
3 empty 2.32 65.7 29.5 No No
4 empty 2.23 66.9 30 No No
5 empty 2.2 66.7 24.6 No No
6 empty 2.02 79.1 13.7 No No
7 empty 2.2 61.6 16 No No
8 empty 2.35 73.6 12.1 No No
9 empty 1.7 65.3 10.3 No No
10 empty 2.59 74.4 9.1 No No
5HZN_G Insulin-like growth factor 1 receptor Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.55 67.1 53.4 Yes Yes
2 empty 2.47 63.8 30.1 No No
3 empty 2.17 60.3 24 No No
4 bound 2.11 72.8 13.9 No No
5 empty 1.91 72.2 20.2 No No
6 empty 2.5 58.2 18.5 No No
7 empty 2.26 64.8 13.1 No No
8 empty 1.92 65.2 14.2 No No
9 empty 2.33 63.3 16.7 No No
10 empty 1.86 65.1 10.4 No No
1M7N_A Insulin-like growth factor 1 receptor Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.6 64.7 45.2 Yes No
2 empty 2.06 68.3 40.9 No No
3 empty 2.07 63.7 26.6 No No
4 empty 2.09 79 18.2 No No
5 empty 2.31 57.6 24.7 No No
6 empty 2.03 62.7 20 No No
7 empty 2.15 64.3 26 No No
8 empty 2.43 65.1 13.8 No No
9 empty 2.22 65.7 17.3 No No
10 empty 1.98 69.1 13.1 No No
5HZN_H Insulin-like growth factor 1 receptor Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.58 70.9 48.4 Yes Yes
2 empty 1.92 65.4 43.8 No No
3 empty 2.13 60.7 28.6 No No
4 bound 2.32 66.7 16.3 No No
5 empty 1.91 60.4 22.4 No No
6 empty 2.48 59.5 19.4 No No
7 empty 2.38 59.9 12.3 No No
8 empty 1.88 67.3 9.6 No No
9 empty 2.14 63.1 9.9 No No
10 empty 2.46 76.3 9.4 No No
2ZM3_D Insulin-like growth factor 1 receptor Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.94 72.1 38.4 Yes Yes
2 empty 2.26 66.1 42.7 No No
3 empty 2.15 65.1 31.1 No No
4 empty 2.05 66.1 34.3 No No
5 empty 2.39 68 22.5 No No
6 empty 2.46 64.3 24.4 No No
7 empty 2.55 70.7 16.4 No No
8 empty 2.52 67.4 10.4 No No
9 empty 2.34 68.8 8.4 No No
10 empty 1.96 58.9 9.3 No No
1P4O_A Insulin-like growth factor 1 receptor Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.67 62.1 41.9 Yes No
2 empty 2.06 63.8 27.1 No No
3 empty 2.01 70.5 25.9 No No
4 empty 2.31 65.9 30.6 No No
5 empty 2.13 73.6 21.3 No No
6 empty 1.74 59.4 21.4 No No
7 empty 2.39 65.6 13.1 No No
8 empty 2.32 68.4 17.4 No No
9 empty 2.35 58.5 16.3 No No
10 empty 1.92 64.6 14.9 No No
3LVP_A Insulin-like growth factor 1 receptor Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.75 64.4 37.7 Yes No
2 empty 2.11 65.5 27.8 No No
3 empty 2.1 59.5 28.3 No No
4 empty 1.95 54 21 No No
5 empty 2.36 57.2 19.9 No No
6 empty 1.9 53 20.3 No No
7 empty 2.21 67.8 15.8 No No
8 empty 1.75 71.2 12.1 No No
9 bound 2.41 49.2 14.2 No No
10 empty 1.54 71.3 10 No No
2ZM3_A Insulin-like growth factor 1 receptor Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.86 69.1 50.8 Yes Yes
2 empty 2.3 64.7 32 No No
3 empty 2.52 66.4 24.5 No No
4 empty 2.13 64.1 23.3 No No
5 empty 2.05 73.8 23.6 No No
6 empty 2.25 57.2 12 No No
7 empty 2.24 70.4 13.5 No No
8 empty 2.43 65.8 10.1 No No
9 empty 2.32 77.7 8.6 No No
10 empty 1.96 72.1 9.1 No No
1JQH_A Insulin-like growth factor 1 receptor Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.96 78.6 23.2 Yes No
2 empty 2.14 62.1 35.4 No No
3 empty 2.37 64.3 38.5 No No
4 empty 2.16 58.4 35.7 No No
5 bound 2.27 70 25.5 No No
6 empty 2.14 59.6 23.1 No No
7 empty 2.38 66.2 12.2 No No
8 empty 1.89 71.7 11.1 No No
9 empty 1.72 70.4 11.2 No No
10 empty 1.92 74.1 9.4 No No
3F5P_T Insulin-like growth factor 1 receptor Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.98 62.8 54.4 Yes No
2 bound 1.65 67.9 41.9 No No
3 empty 2.42 66.5 25.5 No No
4 empty 2.15 64.1 30.7 No No
5 empty 2.02 71.5 18.3 No No
6 empty 2.1 62.9 17 No No
7 empty 2.23 74.2 14.7 No No
8 empty 2.78 72.2 8.1 No No
9 empty 2.3 68.7 12 No No
10 empty 2.38 62.9 9.9 No No
5HZN_F Insulin-like growth factor 1 receptor Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.52 66.1 50.9 Yes Yes
2 empty 2.3 67.1 26.8 No No
3 empty 1.99 59.4 19.1 No No
4 bound 2.23 69.5 18.1 No No
5 empty 1.97 74.9 20.4 No No
6 empty 2.42 59.7 16.6 No No
7 empty 2.32 58.3 12.3 No No
8 empty 2.04 60.5 11.7 No No
9 empty 1.88 58.6 10.1 No No
10 empty 2.41 60.2 13.7 No No
3F5P_D Insulin-like growth factor 1 receptor Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.61 66.1 48.2 Yes No
2 empty 2.23 65.4 35.8 No No
3 empty 2.23 68 27.5 No No
4 empty 2.47 72 14.7 No No
5 empty 2.05 72.7 14.2 No No
6 empty 2.18 63.9 14.1 No No
7 empty 2.25 76.9 11.7 No No
8 empty 2.21 69.4 13.6 No No
9 empty 2.37 74.4 8.4 No No
10 empty 2.34 65.8 10.6 No No
3F5P_I Insulin-like growth factor 1 receptor Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.81 68.6 40.3 Yes Yes
2 empty 2.14 64.8 31.8 No No
3 empty 2.35 65.6 30.1 No No
4 empty 2.15 64.6 21.7 No No
5 empty 2.06 64.6 31.4 No No
6 empty 1.99 73.1 20.4 No No
7 empty 2.1 62.1 16.6 No No
8 empty 2.2 74.9 13.4 No No
9 empty 2.25 52.2 10.6 No No
10 empty 2.37 66.9 14 No No
3QQU_C Insulin-like growth factor 1 receptor Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.29 66 33.8 Yes No
2 empty 2.08 63.3 32.6 No No
3 empty 2.07 65.3 27.1 No No
4 bound 2.06 81.1 23.8 No No
5 empty 2.1 66.2 23 No No
6 empty 2.5 67.2 13.6 No No
7 empty 1.96 61.3 18.8 No No
8 empty 1.84 64.4 21.8 No No
9 empty 1.97 68.7 13.2 No No
10 empty 2.26 63.1 13.6 No No
3LW0_D Insulin-like growth factor 1 receptor Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.49 71.8 35.4 Yes Yes
2 empty 2.17 63 43.3 No No
3 empty 2.29 64.3 25.9 No No
4 empty 2.14 72.2 22.9 No No
5 bound 1.85 73.4 19.9 No No
6 empty 2.22 55.2 20.6 No No
7 empty 2.03 62.4 17.2 No No
8 empty 2.54 65.2 12.8 No No
9 empty 2 72 14 No No
10 empty 1.58 62.1 13.5 No No
3NW7_A Insulin-like growth factor 1 receptor Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.12 64 30.4 Yes No
2 bound 1.58 77.4 29.7 Yes No
3 empty 2.35 64.5 27.9 No No
4 empty 1.91 70.2 29.5 No No
5 empty 2.3 63.4 26.1 No No
6 empty 2.32 60.4 22.3 No No
7 empty 2.04 72.3 12.1 No No
8 empty 2.05 62.2 19.8 No No
9 empty 1.87 66.1 12.9 No No
10 empty 2.04 60.2 9.3 No No
5FXS_A Insulin-like growth factor 1 receptor Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.66 65.9 34.5 Yes No
2 empty 2.04 65 25.9 No No
3 bound 1.5 73 20.8 No No
4 empty 1.95 63.7 18.4 No No
5 empty 1.56 66 12.8 No No
6 empty 1.75 67.9 14.3 No No
7 empty 1.29 69.6 11.5 No No
8 empty 1.8 50.3 12.2 No No
9 empty 1.98 70.5 12.2 No No
10 empty 2.08 60.2 13 No No
3LVP_D Insulin-like growth factor 1 receptor Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.8 64.5 42.4 Yes No
2 empty 2.09 64.9 34.2 No No
3 empty 2.17 62.1 26.8 No No
4 empty 2.11 68.9 27.5 No No
5 empty 2.3 67.6 16.4 No No
6 empty 2.31 60.4 18.3 No No
7 empty 2.09 77.5 9.6 No No
8 empty 2.71 62.4 11.3 No No
9 empty 2.08 66.8 12.1 No No
10 empty 2.48 74.1 8.8 No No
3I81_A Insulin-like growth factor 1 receptor Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.19 64 31.5 Yes No
2 empty 1.87 65.5 26.3 No No
3 empty 2.39 68.6 26.2 No No
4 bound 1.81 75.8 24.5 No No
5 empty 2.03 75.8 18 No No
6 empty 2.36 58 22.6 No No
7 empty 2.63 69 20.7 No No
8 empty 2.07 64.6 14 No No
9 empty 2.1 75.3 8.7 No No
10 empty 2.11 65.1 18.4 No No
1JQH_B Insulin-like growth factor 1 receptor Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.02 71.9 27.4 Yes Yes
2 empty 2.14 61.2 28.2 No No
3 empty 1.99 60.6 15.7 No No
4 empty 1.78 60.1 18.3 No No
5 empty 2.2 65.6 11.5 No No
6 empty 2.38 62.7 12.1 No No
7 empty 1.97 63.8 16.4 No No
8 empty 2.26 61.5 13 No No
9 empty 2.09 64.7 10.8 No No
10 empty 2.2 60.5 12.5 No No
3LW0_A Insulin-like growth factor 1 receptor Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.48 70 33.3 Yes Yes
2 empty 2.19 62.7 33.1 No No
3 empty 2.37 65.9 25.9 No No
4 empty 2.4 59 28.8 No No
5 empty 2.26 73.1 21.6 No No
6 bound 1.94 73.3 15 No No
7 empty 2.28 61.9 18.6 No No
8 empty 2.45 63.4 12.7 No No
9 empty 1.99 67.5 13.9 No No
10 empty 1.7 61.1 13.2 No No
4D2R_A Insulin-like growth factor 1 receptor Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.79 67 31.8 Yes Yes
2 empty 2.13 64.2 31.6 No No
3 empty 1.9 68.3 33.9 No No
4 bound 1.66 79.7 17.1 No No
5 empty 2.22 68.3 26.1 No No
6 empty 2.32 56.6 19.7 No No
7 empty 1.94 74.8 12 No No
8 empty 1.94 65.3 9.2 No No
9 empty 2.12 58.9 14 No No
10 empty 2.11 64.4 14.3 No No
5HZN_D Insulin-like growth factor 1 receptor Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.61 70 47.6 Yes Yes
2 empty 2.4 63.5 32.3 No No
3 empty 2.12 62.4 27.7 No No
4 bound 2.19 63.3 28.6 No No
5 empty 2.11 61.6 26.8 No No
6 empty 1.77 69.6 28.8 No No
7 empty 2.52 62.6 18.3 No No
8 empty 2.14 66.8 9.4 No No
9 empty 2.4 73.6 9.7 No No
10 empty 1.85 61.4 9.7 No No
3F5P_K Insulin-like growth factor 1 receptor Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.63 68.3 39.4 Yes Yes
2 empty 2.13 65.5 36.8 No No
3 empty 2.25 67.1 32.9 No No
4 empty 2.4 65.3 25.2 No No
5 empty 2.44 69.1 27 No No
6 empty 1.93 73.5 17.7 No No
7 empty 2.24 72.4 13.1 No No
8 empty 2.09 62.1 17.1 No No
9 empty 2.52 71.7 8.4 No No
10 empty 2.37 67.6 10.9 No No
3F5P_H Insulin-like growth factor 1 receptor Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.59 69.7 39.6 Yes Yes
2 empty 2.1 65.5 52.2 No No
3 empty 2.19 65.1 24.1 No No
4 empty 2.04 66.6 20.3 No No
5 empty 2.36 71.9 17.6 No No
6 empty 2.59 61.8 22.4 No No
7 empty 2.08 72.7 21.1 No No
8 empty 2.34 62.2 17.5 No No
9 empty 2.11 61.7 23.8 No No
10 empty 2.15 73.9 12.8 No No
3F5P_F Insulin-like growth factor 1 receptor Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.59 68.8 39.5 Yes Yes
2 empty 2.18 63.7 36.4 No No
3 empty 2.15 65.1 36.6 No No
4 empty 2.4 68.9 35.3 No No
5 empty 2.41 65.8 22 No No
6 empty 2.02 74.7 13.1 No No
7 empty 2.16 79.5 10.9 No No
8 empty 2.06 61.5 15.8 No No
9 empty 1.77 67 17.2 No No
10 empty 2.23 56.4 11.1 No No
5HZN_B Insulin-like growth factor 1 receptor Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.26 64.4 53.3 Yes No
2 bound 1.51 75.6 27.9 Yes No
3 empty 2.39 67.6 27.2 No No
4 bound 2.3 67.3 27.9 No No
5 empty 2.15 58 28.6 No No
6 empty 1.97 72.8 20 No No
7 empty 2.44 59.6 16.9 No No
8 empty 1.88 61.4 10.6 No No
9 empty 2.33 62.7 13.9 No No
10 empty 2.22 59.2 11.1 No No
3F5P_S Insulin-like growth factor 1 receptor Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.65 66.2 51.1 Yes Yes
2 empty 2.18 66 31 No No
3 empty 2.42 67 29.1 No No
4 empty 2.03 72.8 22 No No
5 empty 2.05 59.9 17.6 No No
6 empty 2.29 64.3 12.1 No No
7 empty 2.56 76.7 10.4 No No
8 empty 2.28 71.1 8.8 No No
9 empty 1.98 55.7 8.8 No No
10 empty 2.58 65.4 9.1 No No
2ZM3_B Insulin-like growth factor 1 receptor Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.91 68.4 41.1 Yes Yes
2 empty 2.12 62.1 30.3 No No
3 empty 2.5 67.9 27.3 No No
4 empty 2.01 66.9 29.3 No No
5 empty 2.46 64.6 30.9 No No
6 empty 2.09 74.4 16.1 No No
7 empty 2.28 63.2 19 No No
8 empty 2.39 74.7 9.5 No No
9 empty 2.71 60.4 14.5 No No
10 empty 2.47 65.8 11.2 No No
3O23_A Insulin-like growth factor 1 receptor Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.68 71.1 44.3 Yes Yes
2 empty 1.95 68.5 43.6 No No
3 empty 2.02 62.5 28.1 No No
4 empty 2.32 65.4 25.7 No No
5 empty 2.14 58.3 18.9 No No
6 empty 2 65.3 14.9 No No
7 empty 1.82 70.2 12 No No
8 empty 2.47 56.4 17 No No
9 empty 1.36 66.7 9.2 No No
10 empty 2.35 59.5 14 No No
3LVP_C Insulin-like growth factor 1 receptor Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.92 66.6 35.9 Yes Yes
2 empty 2.31 62.1 27.6 No No
3 empty 2.25 60 28.3 No No
4 empty 1.71 56.2 18.9 No No
5 empty 2.17 55.5 22.1 No No
6 empty 2.11 62.2 13.8 No No
7 empty 2.29 62 20 No No
8 empty 1.75 76.5 12.3 No No
9 empty 1.85 67.3 13.6 No No
10 empty 2.28 59.4 14 No No
3NW6_A Insulin-like growth factor 1 receptor Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.85 67.2 32.1 Yes Yes
2 empty 2.1 68.5 44 No No
3 empty 2.17 66.8 25.6 No No
4 bound 1.73 84.6 19.7 Yes No
5 empty 2.19 65 13.5 No No
6 empty 2.33 61.4 23.9 No No
7 empty 2.33 64.4 12.7 No No
8 empty 1.88 65.9 13.2 No No
9 empty 2.16 70.2 9.5 No No
10 empty 2.15 72.5 17.3 No No
5U8Q_A Insulin-like growth factor 1 receptor Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.36 70.8 32.3 Yes Yes
2 empty 2.2 64.5 28.8 No No
3 empty 2.25 73.8 20.9 No No
4 empty 2.14 61 28.2 No No
5 empty 2.01 56.5 29.2 No No
6 empty 1.9 65.5 33.4 No No
7 empty 2.32 64.2 25.6 No No
8 empty 2.41 61.1 22 No No
9 empty 1.68 51 23.3 No No
10 empty 2.26 60 18.6 No No
3D94_A Insulin-like growth factor 1 receptor Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.51 71.2 45.2 Yes Yes
2 empty 2.2 63.4 27.2 No No
3 empty 2.5 63.5 25.1 No No
4 empty 2.14 58.2 23.9 No No
5 empty 1.95 73.1 19.8 No No
6 empty 2.39 61 15.3 No No
7 empty 1.82 73.2 10.7 No No
8 empty 1.6 60.4 10.2 No No
9 empty 1.57 66.3 16.9 No No
10 empty 2.58 74.9 10.4 No No
5FXQ_A Insulin-like growth factor 1 receptor Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.96 62.3 27.3 Yes No
2 empty 1.71 63.4 21.6 No No
3 bound 1.47 77.5 15.8 No No
4 empty 2.12 62.6 23.6 No No
5 empty 1.91 60.7 17.1 No No
6 empty 1.64 67.6 13.2 No No
7 empty 1.83 62.1 14 No No
8 empty 1.46 67.2 10.6 No No
9 empty 2.07 51.9 15.1 No No
10 empty 1.87 48.5 11.7 No No
3LW0_C Insulin-like growth factor 1 receptor Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.55 68.5 38.5 Yes Yes
2 empty 2.23 61.5 40.1 No No
3 empty 2.4 64.5 26.8 No No
4 empty 2.2 60.7 25.8 No No
5 empty 2 72.7 19.7 No No
6 bound 1.96 73.7 22.6 No No
7 empty 2.51 61.7 13.7 No No
8 empty 2.32 65.2 11.9 No No
9 empty 1.69 68 14.5 No No
10 empty 1.76 55 14.5 No No
5HZN_C Insulin-like growth factor 1 receptor Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.63 67.3 53.6 Yes Yes
2 empty 2.28 63.6 29.5 No No
3 empty 2.32 60.6 31.2 No No
4 bound 2.1 71.6 19.4 No No
5 empty 1.92 70 18.2 No No
6 empty 2.45 58.9 18.9 No No
7 empty 2.23 59.8 13.7 No No
8 empty 2.08 71 13.6 No No
9 empty 2.32 66.5 14.8 No No
10 empty 2.51 61.6 11.1 No No
3QQU_B Insulin-like growth factor 1 receptor Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.75 73.6 29.3 Yes No
2 empty 2.07 66.4 29 No No
3 empty 2.48 67 34.8 No No
4 empty 2.24 67.2 22.1 No No
5 empty 1.94 69.3 20.9 No No
6 empty 2.06 62 25.3 No No
7 empty 1.98 60.7 16.6 No No
8 empty 1.98 65.7 12 No No
9 empty 2.48 60.1 15 No No
10 empty 2.36 57.3 13.4 No No
5HZN_E Insulin-like growth factor 1 receptor Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.07 64.8 37.7 Yes No
2 empty 2.18 59.4 28.1 No No
3 bound 1.6 71.9 23.3 No No
4 empty 2.21 65.6 17.5 No No
5 bound 2.07 67.2 19.6 No No
6 empty 1.99 60.1 20.3 No No
7 empty 1.79 74 16.1 No No
8 empty 2.39 63.9 14.4 No No
9 empty 1.74 68.8 11.3 No No
10 empty 2.46 49.8 12.4 No No
3F5P_A Insulin-like growth factor 1 receptor Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.68 68.5 39.7 Yes Yes
2 empty 2.15 62.7 43.2 No No
3 empty 2 66.8 23.3 No No
4 empty 2.25 67.3 22.5 No No
5 empty 2.43 69.5 19.2 No No
6 empty 2.18 71.2 21.4 No No
7 empty 2.47 55.1 18.6 No No
8 empty 2.13 60.1 20.4 No No
9 empty 2.34 79 13 No No
10 empty 2.25 59.6 17.8 No No
1P4O_B Insulin-like growth factor 1 receptor Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.59 63 51.3 Yes No
2 empty 1.99 69.5 25.1 No No
3 empty 2.33 67.5 26.4 No No
4 empty 2.08 77.4 18.7 No No
5 empty 2.17 63.1 19.4 No No
6 empty 2.19 65.7 18.6 No No
7 empty 2.03 59.1 14.5 No No
8 empty 1.83 68.6 13.9 No No
9 empty 1.93 66.9 11.8 No No
10 empty 2.41 71.9 8.8 No No
3LVP_B Insulin-like growth factor 1 receptor Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.84 70.4 39.7 Yes Yes
2 empty 2.15 57.1 37.7 No No
3 empty 1.93 62.5 29.1 No No
4 empty 2.22 59.6 23.5 No No
5 empty 2.16 64.9 15.3 No No
6 empty 1.89 69.1 10.4 No No
7 empty 2.21 60.4 13.3 No No
8 empty 2.01 61.9 16 No No
9 empty 1.91 74 9.3 No No
10 empty 2.12 66.3 10.5 No No
1IGR_A Insulin-like growth factor 1 receptor Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.03 64.1 25.7 Yes No
2 bound 2.13 64.4 30.8 No No
3 bound 1.79 66.5 38.9 No No
4 bound 2.01 59.1 29.8 No No
5 empty 1.73 52.3 25.8 No No
6 empty 2.15 57.8 24.8 No No
7 bound 2.52 65.5 20.6 No No
8 empty 2.48 64.6 16 No No
9 empty 2.21 58.1 18.9 No No
10 empty 1.84 53.8 15.1 No No
3F5P_J Insulin-like growth factor 1 receptor Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.71 67.9 40.3 Yes Yes
2 empty 2.18 64.3 38 No No
3 empty 2.38 64.7 27.4 No No
4 empty 2.14 67.1 27.8 No No
5 empty 2.49 65.9 22.9 No No
6 empty 1.94 74.3 15 No No
7 empty 2.14 62.9 16.2 No No
8 empty 2.2 75.4 13.2 No No
9 empty 1.63 68 11.6 No No
10 empty 2.25 69.2 10.9 No No
2ZM3_C Insulin-like growth factor 1 receptor Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.93 69.7 40.5 Yes Yes
2 empty 2.01 64.5 26.1 No No
3 empty 2.13 67.8 31.9 No No
4 empty 2.4 64.9 24.6 No No
5 empty 2.17 64.5 25 No No
6 empty 2.04 76.7 18.7 No No
7 empty 2.56 69.6 18.1 No No
8 empty 2.37 58.4 20.1 No No
9 empty 2.1 64.8 18.2 No No
10 empty 2.64 58.5 15.1 No No
3F5P_C Insulin-like growth factor 1 receptor Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.09 62.7 59.9 Yes No
2 bound 1.65 67.5 41.5 No No
3 empty 2.35 63.9 32.7 No No
4 empty 2.36 65.7 31 No No
5 empty 1.89 69.3 22.5 No No
6 empty 2.23 72 12.7 No No
7 empty 2.18 59.5 16.2 No No
8 empty 1.84 66.4 8.1 No No
9 empty 2.42 67.8 8.8 No No
10 empty 2.23 52 10.7 No No
3QQU_D Insulin-like growth factor 1 receptor Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.09 67.8 42.8 Yes Yes
2 empty 2.1 64.3 25.4 No No
3 empty 2.05 69.6 24.3 No No
4 empty 2.3 66.8 24.4 No No
5 empty 1.91 62.6 15.5 No No
6 empty 2.09 63.4 22.5 No No
7 empty 1.92 75.2 12.5 No No
8 empty 2.08 64.2 11.2 No No
9 empty 2.16 62.6 11.7 No No
10 empty 2.27 61 13.4 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed34
Domains assessed as druggable using the strict criteria20
Domains assessed as druggable using the relaxed criteria33

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
1IGR_A (30877) Insulin-like growth factor 1 receptor Leucine-rich repeat LRR (right-handed beta-alpha superhelix), L domain-like, L domain 2.6Å No No
1IGR_A (30878) Insulin-like growth factor 1 receptor Leucine-rich repeat LRR (right-handed beta-alpha superhelix), L domain-like, L domain 2.6Å Yes No
1IGR_A (44188) Insulin-like growth factor 1 receptor Knottins (small inhibitors toxins lectins), Growth factor receptor domain, Growth factor receptor domain 2.6Å Yes No
1JQH_C (71795) Insulin-like growth factor 1 receptor Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 2.1Å Yes Yes
1JQH_A (71793) Insulin-like growth factor 1 receptor Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 2.1Å Yes No
1JQH_B (71794) Insulin-like growth factor 1 receptor Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 2.1Å Yes Yes
1K3A_A (68098) Insulin-like growth factor 1 receptor Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 2.1Å Yes No
1M7N_B (78739) Insulin-like growth factor 1 receptor Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 2.7Å Yes Yes
1M7N_A (78738) Insulin-like growth factor 1 receptor Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 2.7Å Yes No
1P4O_B (87776) Insulin-like growth factor 1 receptor Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 1.5Å Yes No
1P4O_A (4209772) Insulin-like growth factor 1 receptor Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit (Homo Multimer) 1.5Å Yes No
1P4O_B (4209772) Insulin-like growth factor 1 receptor Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit (Homo Multimer) 1.5Å Yes No
1P4O_A (87775) Insulin-like growth factor 1 receptor Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 1.5Å Yes No
2OJ9_A (139102) Insulin-like growth factor 1 receptor Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 2Å Yes Yes
2ZM3_C (154686) Insulin-like growth factor 1 receptor Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 2.27Å Yes Yes
2ZM3_A (154684) Insulin-like growth factor 1 receptor Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 2.27Å Yes Yes
2ZM3_B (154685) Insulin-like growth factor 1 receptor Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 2.27Å Yes Yes
2ZM3_D (4009246) Insulin-like growth factor 1 receptor Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit (Homo Multimer) 2.27Å Yes Yes
2ZM3_B (4009246) Insulin-like growth factor 1 receptor Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit (Homo Multimer) 2.27Å Yes Yes
2ZM3_A (4009246) Insulin-like growth factor 1 receptor Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit (Homo Multimer) 2.27Å Yes Yes
2ZM3_C (4009246) Insulin-like growth factor 1 receptor Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit (Homo Multimer) 2.27Å Yes Yes
2ZM3_D (154687) Insulin-like growth factor 1 receptor Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 2.27Å Yes No
3D94_A (3350849) Insulin-like growth factor 1 receptor Protein kinase-like (PK-like), Protein kinase-like (PK-like), UNMATCHED 2.3Å Yes Yes
3F5P_A (3400262) Insulin-like growth factor 1 receptor Protein kinase-like (PK-like), Protein kinase-like (PK-like), UNMATCHED 2.9Å Yes Yes
3I81_A (3470355) Insulin-like growth factor 1 receptor Protein kinase-like (PK-like), Protein kinase-like (PK-like), UNMATCHED 2.08Å Yes No
3LVP_A (3540023) Insulin-like growth factor 1 receptor Protein kinase-like (PK-like), Protein kinase-like (PK-like), UNMATCHED 3Å Yes No
3LW0_C (4239241) Insulin-like growth factor 1 receptor Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 1.79Å Yes Yes
3LW0_B (4189724) Insulin-like growth factor 1 receptor Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 1.79Å Yes Yes
3LW0_D (4012599) Insulin-like growth factor 1 receptor Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 1.79Å Yes Yes
3LW0_A (4040953) Insulin-like growth factor 1 receptor Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 1.79Å Yes Yes
3NW5_A (3570119) Insulin-like growth factor 1 receptor Protein kinase-like (PK-like), Protein kinase-like (PK-like), UNMATCHED 2.14Å Yes Yes
3NW6_A (3570120) Insulin-like growth factor 1 receptor Protein kinase-like (PK-like), Protein kinase-like (PK-like), UNMATCHED 2.2Å Yes Yes
3NW7_A (3570121) Insulin-like growth factor 1 receptor Protein kinase-like (PK-like), Protein kinase-like (PK-like), UNMATCHED 2.11Å Yes No
3O23_A (4094419) Insulin-like growth factor 1 receptor Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 2.1Å Yes Yes
3QQU_B (4110781) Insulin-like growth factor 1 receptor Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 2.9Å Yes Yes
3QQU_A (4240033) Insulin-like growth factor 1 receptor Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 2.9Å Yes Yes
3QQU_D (4213817) Insulin-like growth factor 1 receptor Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 2.9Å Yes Yes
3QQU_C (4143064) Insulin-like growth factor 1 receptor Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 2.9Å Yes No
Ligand-based Druggability Score: 1.15
Ligand-based Druggability Score Percentile: 92%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


IGF1R is involved in 61 interactions in the network.


Druggability
Overall Druggability Percentile: 99.71
Druggability for Cancer Therapeutics: 98.82
Druggability for Other Therapeutics: 99.33
Cancer-Associated
Cancer-associated percentile : 98.04
Network Articulation Point
Is IGF1R critical for communication in the network?


Detailed Graph Legend:Help