Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

B4GALT1 (P08037) - Overview - Molecular Target Synopsis

Protein


B4GALT1, Beta-1,4-galactosyltransferase 1
Enzyme Classification 2.4.1.-
UniProt P08037

Also Known as B4GT1_BOVIN, B4GALT1, GALT, GGTB2

The Golgi complex form catalyzes the production of lactose in the lactating mammary gland and could also be responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids., The cell surface form functions as a recognition molecule during a variety of cell to cell and cell to matrix interactions, as those occurring during development and egg fertilization, by binding to specific oligosaccharide ligands on opposing cells or in the extracellular matrix. Homodimer; and heterodimer with alpha-lactalbumin to form lactose synthase (PubMed:10393171, PubMed:11419947, PubMed:12051854, PubMed:12927542). Interacts (via N-terminal cytoplasmic domain) with UBE2Q1 (via N-terminus); the interaction is direct.

4KRV
CRYSTAL STRUCTURE OF CATALYTIC DOMAIN OF BOVINE BETA1,4- GALACTOSYLTRANSFERASE MUTANT M344H-GALT1 COMPLEX WITH 6-SULFO-GLCNAC
RCSB/PDB
Inspect Structure
See all 3D Structures for B4GALT1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
402P08037-1
389P08037-2

Sub-cellular localization


UniProt: B4GALT1 is active in the following subcellular-locations: cell membrane, cell projection, cell surface, filopodium, golgi apparatus, golgi stack membrane, secreted.
GO terms: B4GALT1 is active in the following subcellular-locations: basolateral plasma membrane, brush border membrane, desmosome, external side of plasma membrane, extracellular space, filopodium, Golgi apparatus, Golgi cisterna membrane, Golgi trans cisterna, integral component of membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project B4GALT1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For B4GALT1 there are:
20 structures (39 chains) solved
19 are solved in complex with at least one small molecule ligand
2 are solved with an approved drug

B4GALT1 is solved in complex with the approved drug(s):

BGC/DEXTROSE (1NF5_B, 1NF5_D, 2FYD_B, 2FYD_D).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


B4GALT1 has been screened with 35 compounds (55 bioactivities). (see details)