Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

cex (P07986) - Overview - Molecular Target Synopsis

Protein


cex, Exoglucanase/xylanase
Enzyme Classification 3.2.1.91
UniProt P07986

Also Known as GUX_CELFI, cex, xynB

Hydrolyzes both cellulose and xylan. Has also weak endoglucanase activity., The biological conversion of cellulose to glucose generally requires three types of hydrolytic enzymes: (1) Endoglucanases which cut internal beta-1,4-glucosidic bonds; (2) Exocellobiohydrolases that cut the disaccharide cellobiose from the non-reducing end of the cellulose polymer chain; (3) Beta-1,4-glucosidases which hydrolyze the cellobiose and other short cello-oligosaccharides to glucose.

3CUI
CELLULOMONAS FIMI XYLANASE/CELLULASE CEX (CF XYN10A) IN COMPLEX WITH SULFUR SUBSTITUTED BETA-1,4 XYLOTETRAOSE
RCSB/PDB
Inspect Structure
See all 3D Structures for cex

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
484P07986-1

Gene Copy Number Variation


In COSMIC - Cell Lines Project cex has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For cex there are:
16 structures (16 chains) solved
13 are solved in complex with at least one small molecule ligand
2 are solved with an approved drug

cex is solved in complex with the approved drug(s):

BGC/DEXTROSE (1EXP_A, 2HIS_A),
G2F/FLUDEOXYGLUCOSE (1EXP_A).

(see details)
Molecular Target 3D Synopsis