Molecular Target Synopsis
Overview
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RET (P07949) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 02/04/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 02/04/2019)


Chains assessed18
Chains with at least one site assessed as druggable using the strict criteria11
Chains with at least one site assessed as druggable using the relaxed criteria18


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
5FM3_A Proto-oncogene tyrosine-protein kinase receptor Ret Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.39 64.5 28.6 Yes No
2 bound 1.84 73 28.4 No No
3 empty 2.21 55 19.2 No No
4 empty 1.8 59 14.7 No No
5 empty 1.86 57.6 23.8 No No
6 empty 1.91 60.4 13.1 No No
7 bound 2.31 82 14.1 No No
8 empty 1.44 55.7 17.6 No No
9 empty 1.61 59.4 10.9 No No
10 bound 2.22 61.3 11.7 No No
4CKJ_A Proto-oncogene tyrosine-protein kinase receptor Ret Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.74 64.5 27.2 Yes No
2 bound 2.07 65.9 28.8 No No
3 bound 2.1 73.8 15 No No
4 empty 2.2 62 17.7 No No
5 empty 2.05 60.8 28.4 No No
6 empty 1.8 60.8 17.2 No No
7 bound 1.94 50.5 15.9 No No
8 empty 1.93 61.5 15.8 No No
9 empty 2.11 57.4 14.2 No No
10 empty 1.63 62.2 11.3 No No
2X2M_B Proto-oncogene tyrosine-protein kinase receptor Ret Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.84 71.4 31.9 Yes Yes
2 bound 1.7 56.6 17.1 No No
3 empty 1.98 70.9 14.7 No No
4 empty 1.52 60.2 19.3 No No
5 empty 1.7 60.1 16.3 No No
6 empty 1.84 61 12.6 No No
7 empty 1.65 68.3 11.3 No No
8 empty 1.39 53.9 16.3 No No
9 empty 2.2 61.3 14.5 No No
10 empty 1.54 62.6 11.6 No No
2IVS_A Proto-oncogene tyrosine-protein kinase receptor Ret Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.81 69.9 29.6 Yes Yes
2 bound 2.23 64 28.2 No No
3 empty 1.99 65.1 30.9 No No
4 empty 1.99 58.9 25.4 No No
5 empty 1.78 60.6 23.1 No No
6 empty 1.75 64.4 18.9 No No
7 empty 1.78 62.3 16.7 No No
8 empty 2.07 61.6 14.1 No No
9 empty 1.8 66.6 11.2 No No
10 empty 1.77 64 10.2 No No
4UX8_B Proto-oncogene tyrosine-protein kinase receptor Ret Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.03 67.2 37.1 Yes Yes
2 empty 1.83 60.9 25.7 No No
3 empty 2.29 63.9 23.2 No No
4 empty 2.31 68.2 21.5 No No
5 empty 2.4 65.4 25.4 No No
6 empty 1.93 73.1 28.3 No No
7 empty 2.55 64.8 21.7 No No
8 empty 2.34 63.1 23.2 No No
9 empty 1.87 69.3 13.8 No No
10 empty 2.05 61.9 16.8 No No
2IVV_A Proto-oncogene tyrosine-protein kinase receptor Ret Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.66 75.6 31.3 Yes Yes
2 empty 2.05 62.6 42.2 No No
3 empty 1.93 65.8 24 No No
4 empty 2.07 62.2 29.1 No No
5 empty 2.09 62.7 27.3 No No
6 empty 1.61 63.3 23.6 No No
7 bound 1.71 65.1 15.9 No No
8 empty 1.96 66.6 14.2 No No
9 empty 2 68.7 9.1 No No
10 empty 1.89 64.5 16.5 No No
4CKI_A Proto-oncogene tyrosine-protein kinase receptor Ret Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.75 65.2 28.4 Yes No
2 empty 2.11 64.5 30.6 No No
3 empty 1.9 72 16.3 No No
4 empty 2.14 57.7 14.9 No No
5 empty 2.03 53.6 15.3 No No
6 empty 1.72 58.9 15 No No
7 empty 2.19 60.2 14.4 No No
8 empty 2.13 63.9 13.9 No No
9 bound 1.62 51.9 13.4 No No
10 empty 1.76 58.9 12.6 No No
6FEK_A Proto-oncogene tyrosine-protein kinase receptor Ret Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.57 67.7 28.7 Yes No
2 empty 1.92 66.4 23.9 No No
3 empty 2.25 65 18.7 No No
4 empty 1.94 70 13.9 No No
5 empty 1.96 59.1 21.1 No No
6 empty 1.69 58.6 14.1 No No
7 empty 1.95 49.5 17.1 No No
8 empty 1.79 66.7 13.1 No No
9 empty 1.89 59.7 16.8 No No
10 empty 1.78 57.5 12.8 No No
5FM2_A Proto-oncogene tyrosine-protein kinase receptor Ret Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.79 70.8 42.3 Yes Yes
2 empty 2.11 65.9 25.1 No No
3 empty 2.28 58.7 19.7 No No
4 empty 2.01 61.9 16 No No
5 empty 1.47 63.1 15.1 No No
6 empty 2.01 58 18.6 No No
7 empty 1.7 63 16.4 No No
8 empty 1.8 58.7 13.2 No No
9 empty 2.56 64.2 11.3 No No
10 empty 1.69 60.6 15.5 No No
2X2L_A Proto-oncogene tyrosine-protein kinase receptor Ret Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.81 67 28.4 Yes Yes
2 empty 1.77 61.9 22.3 No No
3 empty 1.93 52 21 No No
4 empty 1.95 69.2 12.1 No No
5 empty 1.85 59.8 24.4 No No
6 empty 1.77 65.6 17.7 No No
7 empty 2 58.5 16.6 No No
8 empty 1.77 59.5 10.8 No No
9 empty 1.75 53.8 14.2 No No
10 empty 1.91 61.8 8.7 No No
2X2U_A Proto-oncogene tyrosine-protein kinase receptor Ret Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.42 68.8 35.9 Yes No
2 bound 2.18 63.7 26.3 No No
3 bound 1.83 78.6 17.2 No No
4 bound 2.21 70.4 19.4 No No
5 bound 2.78 64 27.1 No No
6 empty 1.21 98.9 0 Yes No
7 bound 1.76 75.5 7.8 No No
8 empty 2 61.5 11 No No
9 empty 2.08 68.8 12.4 No No
10 empty 2 62.5 10.4 No No
2IVU_A Proto-oncogene tyrosine-protein kinase receptor Ret Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.66 70.7 30.2 Yes Yes
2 bound 2 60.6 29.5 No No
3 empty 1.65 60 28 No No
4 empty 1.8 61.1 20.2 No No
5 empty 1.48 70.7 10.7 No No
6 empty 1.85 60.6 12.6 No No
7 empty 2.07 58.8 14.4 No No
8 empty 1.23 57.6 12.7 No No
9 empty 1.82 57.8 12.7 No No
10 empty 2.19 58 12 No No
4UX8_A Proto-oncogene tyrosine-protein kinase receptor Ret Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.07 67.5 31.8 Yes Yes
2 empty 2.07 60.1 26.2 No No
3 empty 2.35 63.7 24.1 No No
4 empty 2.4 70.8 21.6 No No
5 empty 2.34 67.2 20.5 No No
6 empty 2.46 69.9 21.7 No No
7 empty 1.9 73 27.8 No No
8 empty 2.62 66.5 21.9 No No
9 empty 2.17 64.6 25.6 No No
10 empty 1.99 70.9 11.1 No No
2X2M_A Proto-oncogene tyrosine-protein kinase receptor Ret Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.9 66.8 32.4 Yes Yes
2 empty 1.91 71.4 16.4 No No
3 bound 1.74 53.3 16.3 No No
4 empty 1.67 62.4 19.5 No No
5 empty 2.11 62.9 23.1 No No
6 empty 1.99 63.8 18.3 No No
7 empty 1.62 73.3 10.2 No No
8 empty 1.88 70.5 15.8 No No
9 empty 1.64 60.2 12.9 No No
10 empty 2.37 58.5 13.6 No No
2IVT_A Proto-oncogene tyrosine-protein kinase receptor Ret Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.09 65.2 46.4 Yes No
2 bound 1.63 73.8 29.7 Yes No
3 empty 2.2 66.2 32.8 No No
4 empty 1.73 66.5 21.3 No No
5 empty 1.62 66.8 14.4 No No
6 empty 1.88 58.7 13.6 No No
7 empty 1.91 62.9 18 No No
8 empty 1.87 66.6 9.8 No No
9 empty 2.02 68.1 11 No No
10 empty 1.86 64.8 9.8 No No
2X2K_A Proto-oncogene tyrosine-protein kinase receptor Ret Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.7 69.8 36 Yes Yes
2 empty 2.05 63.5 42.3 No No
3 empty 1.99 67.5 20.5 No No
4 empty 2.14 62.6 23.3 No No
5 empty 1.77 63 21.6 No No
6 empty 1.83 63.7 22.1 No No
7 empty 1.7 64.6 13.6 No No
8 empty 1.9 64.6 11.7 No No
9 empty 1.75 70 9.4 No No
10 empty 2.07 66.6 10.1 No No
2IVS_B Proto-oncogene tyrosine-protein kinase receptor Ret Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.81 62.1 30.8 Yes No
2 empty 1.93 59.8 23.4 No No
3 empty 2.18 60.1 17.5 No No
4 empty 1.97 69.1 17.6 No No
5 bound 1.62 59.2 16.8 No No
6 empty 1.38 55.9 12.7 No No
7 empty 1.58 59.4 10.3 No No
8 empty 1.84 53 12 No No
9 empty 1.49 52.9 11.3 No No
10 empty 1.79 56.7 12.9 No No
5AMN_A Proto-oncogene tyrosine-protein kinase receptor Ret Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.78 69.2 35 Yes Yes
2 empty 2.09 66.8 27.7 No No
3 bound 1.79 64.5 23.3 No No
4 empty 2.09 59.6 16.7 No No
5 bound 1.57 62 20.1 No No
6 empty 1.71 52 14.1 No No
7 empty 2.08 57.2 16.2 No No
8 empty 2.31 57.4 17.9 No No
9 empty 2.16 56.9 13.5 No No
10 empty 2.16 61.3 16.6 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed11
Domains assessed as druggable using the strict criteria8
Domains assessed as druggable using the relaxed criteria11

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
2IVS_B (4268623) Proto-oncogene tyrosine-protein kinase receptor Ret Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit (Homo Multimer) 2Å Yes Yes
2IVS_A (4268623) Proto-oncogene tyrosine-protein kinase receptor Ret Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit (Homo Multimer) 2Å Yes Yes
2IVS_A (3120708) Proto-oncogene tyrosine-protein kinase receptor Ret Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 2Å Yes Yes
2IVT_A (3120710) Proto-oncogene tyrosine-protein kinase receptor Ret Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 2.6Å Yes No
2IVU_A (3120712) Proto-oncogene tyrosine-protein kinase receptor Ret Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 2.5Å Yes Yes
2IVV_A (3120714) Proto-oncogene tyrosine-protein kinase receptor Ret Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 2.25Å Yes Yes
2X2K_A (3260525) Proto-oncogene tyrosine-protein kinase receptor Ret Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 2.6Å Yes Yes
2X2L_A (3260527) Proto-oncogene tyrosine-protein kinase receptor Ret Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 2Å Yes Yes
2X2M_A (4055055) Proto-oncogene tyrosine-protein kinase receptor Ret Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit (Homo Multimer) 2.5Å Yes Yes
2X2M_B (4055055) Proto-oncogene tyrosine-protein kinase receptor Ret Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit (Homo Multimer) 2.5Å Yes Yes
2X2M_A (3260529) Proto-oncogene tyrosine-protein kinase receptor Ret Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 2.5Å Yes Yes
2X2U_A (3260537) Proto-oncogene tyrosine-protein kinase receptor Ret PFAM, PFAM, PFAM Cadherin 1.9Å Yes No
2X2U_A (3260536) Proto-oncogene tyrosine-protein kinase receptor Ret Concanavalin A-like lectins/glucanases, Concanavalin A-like lectins/glucanases, Laminin G-like module 1.9Å Yes No
Ligand-based Druggability Score: 1.1
Ligand-based Druggability Score Percentile: 91%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


RET is involved in 47 interactions in the network.


Druggability
Overall Druggability Percentile: 99.81
Druggability for Cancer Therapeutics: 99.84
Druggability for Other Therapeutics: 96.86
Cancer-Associated
Cancer-associated percentile : 99.63
Network Articulation Point
Is RET critical for communication in the network?


Detailed Graph Legend:Help