Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

Mme (P07861) - Overview - Molecular Target Synopsis


Mme, Neprilysin
Enzyme Classification
UniProt P07861

Also Known as NEP_RAT, Mme

Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Displays UV-inducible elastase activity toward skin preelastic and elastic fibers (By similarity). Involved in the degradation of atrial natriuretic factor (ANF) (PubMed:2966343).

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization

UniProt: Mme is active in the following subcellular-locations: cell membrane.
GO terms: Mme is active in the following subcellular-locations: axon, brush border, cytoplasm, dendrite, early endosome, integral component of membrane, membrane, membrane raft, neuron projection terminus, neuronal cell body, plasma membrane, synapse, synaptic vesicle, trans-Golgi network.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project Mme has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

RNA Interference

Mme was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: . (see details)

Screening and Chemistry

Mme has been screened with 468 compounds (546 bioactivities), 312 compounds have bioactivities that show binding affinity of <= 500nM (371 bioactivities). (see details)