Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

Mme (P07861) - Overview - Molecular Target Synopsis

Protein


Mme, Neprilysin
Enzyme Classification 3.4.24.11
UniProt P07861

Also Known as NEP_RAT, Mme

Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Displays UV-inducible elastase activity toward skin preelastic and elastic fibers (By similarity). Involved in the degradation of atrial natriuretic factor (ANF) (PubMed:2966343).

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
750P07861-1

Sub-cellular localization


UniProt: Mme is active in the following subcellular-locations: cell membrane.
GO terms: Mme is active in the following subcellular-locations: axon, brush border, cytoplasm, dendrite, early endosome, integral component of membrane, membrane, membrane raft, neuron projection terminus, neuronal cell body, plasma membrane, synapse, synaptic vesicle, trans-Golgi network.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project Mme has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

RNA Interference


Mme was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: . (see details)


Screening and Chemistry


Mme has been screened with 468 compounds (546 bioactivities), 312 compounds have bioactivities that show binding affinity of <= 500nM (371 bioactivities). (see details)