Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
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Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

EPRS (P07814) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 02/07/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 02/07/2019)


Chains assessed23
Chains with at least one site assessed as druggable using the strict criteria8
Chains with at least one site assessed as druggable using the relaxed criteria23


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
4HVC_A Bifunctional glutamate/proline--tRNA ligase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.78 73.4 50 Yes Yes
2 empty 2.37 63.5 38.2 No No
3 empty 1.46 66.7 26 No No
4 empty 2.19 68.4 18.1 No No
5 empty 1.8 62.1 20.6 No No
6 empty 2.1 61.9 21.6 No No
7 empty 2.02 61.2 15.5 No No
8 empty 1.97 68.7 13.7 No No
9 empty 1.91 64.9 12.7 No No
10 empty 2.31 59.8 20.8 No No
5A34_C Bifunctional glutamate/proline--tRNA ligase Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.82 63.2 41 Yes No
2 empty 2.21 67.5 18.9 No No
3 empty 1.98 60.4 12.1 No No
4 empty 2.02 71.7 9.7 No No
5 empty 2.02 61.4 10.5 No No
6 empty 2.48 57.4 12.8 No No
7 empty 2.43 63.4 9.3 No No
8 empty 2.05 68.2 7.3 No No
9 empty 2.86 69.6 7.3 No No
10 empty 2.23 58.3 9.8 No No
5A5H_E Bifunctional glutamate/proline--tRNA ligase Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.94 61.3 38.6 Yes No
2 empty 2.15 62.6 13.8 No No
3 empty 2.45 66.8 14.3 No No
4 empty 1.83 71.5 14.5 No No
5 empty 2.06 62.6 16 No No
6 empty 2.06 58.2 14.2 No No
7 empty 2.37 59.7 12.9 No No
8 empty 2.48 68.9 11.7 No No
9 empty 2.43 79.1 8.7 No No
10 empty 1.88 64.5 9.7 No No
5BMU_B Bifunctional glutamate/proline--tRNA ligase Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.95 66 31.5 Yes No
2 empty 2.59 66.9 21.5 No No
3 empty 2.15 72.7 11.2 No No
4 empty 2.13 63.2 18.3 No No
5 empty 2.25 63.5 14.2 No No
6 empty 2.31 66.1 10 No No
7 empty 2.19 71 8.7 No No
8 empty 1.96 74.3 10.6 No No
9 empty 2.38 60.4 10.6 No No
10 empty 2.55 62.4 10.3 No No
4K88_A Bifunctional glutamate/proline--tRNA ligase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.87 74.1 51.5 Yes Yes
2 empty 2.14 63.7 29.2 No No
3 empty 2.09 60.1 22.5 No No
4 empty 1.55 65.9 27.4 No No
5 empty 2.28 67.6 17.4 No No
6 empty 1.95 65.4 19.6 No No
7 empty 1.79 62 22.4 No No
8 empty 2.24 65.2 22.4 No No
9 empty 2.03 65.3 28.1 No No
10 empty 2.02 62.8 23.7 No No
5BMU_F Bifunctional glutamate/proline--tRNA ligase Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.12 65.7 28.3 Yes No
2 empty 2.12 58.5 17 No No
3 empty 2.41 62.9 11.4 No No
4 empty 2.04 80.9 14.1 No No
5 empty 2 68.7 8.1 No No
6 empty 2.65 65.6 13.4 No No
7 empty 2.31 83.9 9.9 No No
8 empty 2.25 59.1 12.7 No No
9 empty 2.62 65.2 9.8 No No
10 empty 2.51 63.3 13.1 No No
5A34_A Bifunctional glutamate/proline--tRNA ligase Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.07 66.6 33.7 Yes No
2 empty 2.23 67.5 14.5 No No
3 empty 2.07 69.3 18.4 No No
4 empty 2.22 57 11.1 No No
5 empty 2 71.5 8.7 No No
6 empty 2.67 66.8 10.9 No No
7 empty 2.19 64.2 12.7 No No
8 empty 1.95 60.4 11.5 No No
9 empty 2.48 64.8 7.2 No No
10 empty 2.34 49.7 8.6 No No
4K86_A Bifunctional glutamate/proline--tRNA ligase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.93 75 46.2 Yes Yes
2 empty 2.1 63.5 26.3 No No
3 empty 1.98 63 25.5 No No
4 empty 2.14 61.2 26 No No
5 empty 1.7 60.2 27.3 No No
6 empty 2.23 60.3 18.8 No No
7 empty 2.23 62 22.7 No No
8 empty 1.87 70.7 20.3 No No
9 empty 1.81 69.9 19 No No
10 empty 2.24 66.7 17.9 No No
4HVC_B Bifunctional glutamate/proline--tRNA ligase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.82 73.5 46.4 Yes Yes
2 empty 1.96 70.1 32.2 No No
3 empty 2.15 61.6 26.7 No No
4 empty 1.48 63.4 24 No No
5 empty 1.99 70.8 15.8 No No
6 empty 2.26 65.1 20.7 No No
7 empty 1.95 56 16.3 No No
8 empty 2.13 60 14.4 No No
9 empty 1.93 68.1 16 No No
10 empty 1.81 56.4 15.2 No No
5A5H_G Bifunctional glutamate/proline--tRNA ligase Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.92 64.8 38.5 Yes No
2 empty 2.43 69.9 15.5 No No
3 empty 2.12 61.3 14 No No
4 empty 2.51 61.3 11.3 No No
5 empty 2.03 75.2 9.2 No No
6 empty 2.22 65 16.2 No No
7 empty 1.78 61.4 9.7 No No
8 empty 2.01 67.6 9.4 No No
9 empty 2.18 69.4 5.6 No No
10 empty 2.07 50.3 7.7 No No
5V58_A Bifunctional glutamate/proline--tRNA ligase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.98 72.1 64.3 Yes Yes
2 empty 2.38 63.7 36.6 No No
3 empty 2.16 63.3 26.3 No No
4 empty 1.42 64.6 26.2 No No
5 empty 1.82 61.5 17.7 No No
6 empty 1.78 71.5 16.3 No No
7 empty 2.02 58.3 17.1 No No
8 empty 1.82 64.9 12.4 No No
9 empty 2.06 67.1 13.6 No No
10 empty 2.43 63.9 18.6 No No
5VAD_B Bifunctional glutamate/proline--tRNA ligase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2 72.7 53.6 Yes Yes
2 empty 2.17 66.8 24.5 No No
3 empty 2.23 64.2 24.6 No No
4 empty 1.54 67.9 26.9 No No
5 empty 2.38 66.1 26.9 No No
6 empty 1.66 62.8 16.3 No No
7 empty 2.08 61.5 18.1 No No
8 empty 2.13 61.2 13.9 No No
9 empty 2.34 63.2 22.1 No No
10 empty 2.31 72.4 10.7 No No
5A1N_A Bifunctional glutamate/proline--tRNA ligase Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.02 64.6 34.5 Yes No
2 empty 2.41 64.8 16.7 No No
3 empty 2.16 66.6 18.5 No No
4 empty 2.01 61.8 20.3 No No
5 empty 2.21 62 13.1 No No
6 empty 2.65 61.1 11.7 No No
7 empty 2.34 74 12.1 No No
8 empty 2.31 69.3 11.8 No No
9 empty 2 54.1 12.9 No No
10 empty 1.96 65.2 10.1 No No
5VAD_A Bifunctional glutamate/proline--tRNA ligase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.02 73.1 52.9 Yes Yes
2 empty 1.56 67.5 26.5 No No
3 empty 2.25 69.1 17.8 No No
4 empty 2 65.9 15.9 No No
5 empty 1.73 63 20.9 No No
6 empty 2.14 64.5 22 No No
7 empty 2.01 61.4 17.1 No No
8 empty 2.06 61.7 15.9 No No
9 empty 2.07 69.4 14.2 No No
10 empty 2.31 60.6 15.3 No No
5BMU_H Bifunctional glutamate/proline--tRNA ligase Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.42 65.5 34 Yes No
2 empty 2.34 62.9 19.8 No No
3 empty 2.38 69.9 16.5 No No
4 empty 2.07 67.6 11.6 No No
5 empty 2.85 67.9 11.2 No No
6 empty 2.33 59.4 9.2 No No
7 empty 2.38 69 8.5 No No
8 empty 2.22 73.8 8.9 No No
9 empty 1.75 63.9 8.1 No No
10 empty 2.14 68.9 7.7 No No
5A5H_A Bifunctional glutamate/proline--tRNA ligase Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.1 64.4 33.7 Yes No
2 empty 2.35 67.5 25.9 No No
3 empty 2.1 65 14.9 No No
4 empty 1.81 68.2 9.5 No No
5 empty 2 71 16.7 No No
6 empty 2.28 61.5 10.7 No No
7 empty 2.32 64.8 12.7 No No
8 empty 2.46 62.6 9.8 No No
9 empty 1.83 63.3 8.4 No No
10 empty 3 66.5 9.7 No No
5Y6L_C Bifunctional glutamate/proline--tRNA ligase Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.99 65.7 38.4 Yes No
2 empty 2.51 65.3 17.7 No No
3 empty 2.28 58.9 17.5 No No
4 empty 2.17 67.2 9 No No
5 empty 2.35 60.6 11.9 No No
6 empty 2.91 61.3 9.4 No No
7 empty 2.43 67.9 10.6 No No
8 empty 2.45 69.4 10.3 No No
9 empty 2.19 53.9 13.1 No No
10 empty 2.27 59.5 11.7 No No
5A34_E Bifunctional glutamate/proline--tRNA ligase Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.05 65.3 32.6 Yes No
2 empty 2.33 69.9 14.5 No No
3 empty 2.41 69.4 15.4 No No
4 empty 2.24 65.5 17.6 No No
5 empty 2 60.1 20.3 No No
6 empty 2.14 70.7 12.4 No No
7 empty 2.61 54 15 No No
8 empty 2.17 62.1 12.7 No No
9 empty 2.05 62.4 10.5 No No
10 empty 2.51 73.3 7.3 No No
5A5H_C Bifunctional glutamate/proline--tRNA ligase Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.95 65.3 38.2 Yes No
2 empty 2.12 64.7 14.5 No No
3 empty 2.35 59.6 14.5 No No
4 empty 1.96 64.4 12.8 No No
5 empty 2.24 66.7 10 No No
6 empty 2.34 53.4 12.1 No No
7 empty 1.68 63.2 10.2 No No
8 empty 2.59 64.7 10.4 No No
9 empty 2.51 66.3 8.7 No No
10 empty 2.17 77.6 9.7 No No
5BMU_D Bifunctional glutamate/proline--tRNA ligase Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2 63.9 33.7 Yes No
2 empty 2.27 64.6 23.3 No No
3 empty 2.1 63.2 15.2 No No
4 empty 2.09 70.1 11.1 No No
5 empty 2.23 61.4 16.1 No No
6 empty 2.44 71.2 10.5 No No
7 empty 2.45 56.8 10.7 No No
8 empty 2.23 56.4 9.5 No No
9 empty 2.66 58.3 10.2 No No
10 empty 2.73 73.2 7.7 No No
4K87_A Bifunctional glutamate/proline--tRNA ligase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.13 73.5 45 Yes Yes
2 empty 2.16 69 25.9 No No
3 empty 2.21 65.6 26.9 No No
4 empty 1.92 64.1 25.9 No No
5 empty 1.51 68.1 28.6 No No
6 empty 1.92 62 25.8 No No
7 empty 2.15 61.4 22.5 No No
8 empty 2.15 66.8 21.7 No No
9 empty 1.95 59.9 15.3 No No
10 empty 2.14 66.7 18.2 No No
5A34_G Bifunctional glutamate/proline--tRNA ligase Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.94 66.2 31.8 Yes No
2 empty 2.51 63.9 27.9 No No
3 empty 2.2 70 11.3 No No
4 empty 2.15 59.8 13.2 No No
5 empty 2.26 55.2 13.5 No No
6 empty 2.42 70 12.3 No No
7 empty 2 53.1 11.1 No No
8 empty 2.51 65.3 6.6 No No
9 empty 2.05 48.4 9.2 No No
10 empty 1.97 58.7 10.5 No No
1FYJ_A Bifunctional glutamate/proline--tRNA ligase Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.08 59.4 14.3 No No
2 empty 2.03 60.3 10.8 No No
3 empty 2.39 61.5 9.6 No No
4 empty 2.14 49.3 8.9 No No
5 empty 3.02 69.7 6.3 No No
6 empty 2.19 65.1 6.3 No No
7 empty 2.03 98.9 0 Yes No
8 empty 2.56 78.1 6.9 No No
9 empty 2.26 60.6 5.8 No No
10 empty 2.59 64.6 4.3 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed1
Domains assessed as druggable using the strict criteria0
Domains assessed as druggable using the relaxed criteria0

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
1FYJ_A (60115) Bifunctional glutamate/proline--tRNA ligase S15/NS1 RNA-binding domain, S15/NS1 RNA-binding domain, a tRNA synthase domain No No
Ligand-based Druggability Score: -0.6
Ligand-based Druggability Score Percentile: 73%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


EPRS is involved in 14 interactions in the network.


Druggability
Overall Druggability Percentile: 56.23
Druggability for Cancer Therapeutics: 58.49
Druggability for Other Therapeutics: 45.95
Cancer-Associated
Cancer-associated percentile : 75.51
Network Articulation Point
Is EPRS critical for communication in the network?


Detailed Graph Legend:Help