Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

leuS (P07813) - Overview - Molecular Target Synopsis

Protein


leuS, Leucine--tRNA ligase
Enzyme Classification 6.1.1.4
UniProt P07813

Also Known as SYL_ECOLI, leuS

Monomer.

5ONH
QUATERNARY COMPLEX OF WILD TYPE E. COLI LEUCYL-TRNA SYNTHETASE WITH TRNA(LEU), LEUCYL-ADENYLATE ANALOGUE, AND POST-TRANSFER EDITING ANALOGUE OF NORVALINE IN THE AMINOACYLATION CONFORMATION
RCSB/PDB
Inspect Structure
See all 3D Structures for leuS

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
860P07813-1, C4ZWC9-1

Sub-cellular localization


UniProt: leuS is active in the following subcellular-locations: cytoplasm.
GO terms: leuS is active in the following subcellular-locations: cytosol.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project leuS has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For leuS there are:
16 structures (26 chains) solved
10 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

leuS is solved in complex with the approved drug(s):

MET/METHIONINE (2AJH_A, 2AJH_B).

(see details)
Molecular Target 3D Synopsis