Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

CTSL (P07711) - Overview - Molecular Target Synopsis

Protein


CTSL, Cathepsin L1
Enzyme Classification 3.4.22.15
UniProt P07711

Also Known as CATL1_HUMAN, CTSL, CTSL1

Important for the overall degradation of proteins in lysosomes. Dimer of a heavy and a light chain linked by disulfide bonds.

6EZP
CATHEPSIN L IN COMPLEX WITH (3S,14E)-19-CHLORO-N-(1-CYANOCYCLOPROPYL)- 5-OXO-12,17-DIOXA-4-AZATRICYCLO[16.2.2.06,11]DOCOSA-1(21),6(11),7,9, 14,18(22),19-HEPTAENE-3-CARBOXAMIDE
RCSB/PDB
Inspect Structure
See all 3D Structures for CTSL

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
333ENSG00000135047ENST00000340342, ENST00000343150ENSP00000365061, ENSP00000345344P07711-1
225ENSG00000135047ENST00000342020ENSP00000340470

Sub-cellular localization


UniProt: CTSL is active in the following subcellular-locations: lysosome.
GO terms: CTSL is active in the following subcellular-locations: collagen-containing extracellular matrix, endolysosome lumen, extracellular exosome, extracellular region, extracellular space, lysosomal lumen, lysosome, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project CTSL has gain in 0 cell-lines, loss in 1 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H460, Hs 746T, HCC2302

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, A549, HSMM

(see details)

3D Structures


For CTSL there are:
36 structures (78 chains) solved
30 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


CTSL has been screened with 3131 compounds (3920 bioactivities), 849 compounds have bioactivities that show binding affinity of <= 500nM (1045 bioactivities). (see details)