Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ADRB1 (P07700) - Overview - Molecular Target Synopsis

Protein


ADRB1, Beta-1 adrenergic receptor
UniProt P07700

Also Known as ADRB1_MELGA, ADRB1

Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity.

6IBL
ACTIVATED TURKEY BETA1 ADRENOCEPTOR WITH BOUND AGONIST FORMOTEROL AND NANOBODY NB80
RCSB/PDB
Inspect Structure
See all 3D Structures for ADRB1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
483P07700-1

Sub-cellular localization


UniProt: ADRB1 is active in the following subcellular-locations: cell membrane, early endosome.
GO terms: ADRB1 is active in the following subcellular-locations: early endosome, integral component of plasma membrane, membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ADRB1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For ADRB1 there are:
25 structures (49 chains) solved
23 are solved in complex with at least one small molecule ligand
3 are solved with an approved drug

ADRB1 is solved in complex with the approved drug(s):

H98/ARFORMOTEROL (6IBL_A, 6IBL_B),
68H/LEVOSALBUTAMOL (2Y04_A, 2Y04_B, 6H7M_A, 6H7M_B).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ADRB1 has been screened with compounds ( bioactivities). (see details)