Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

Pck1 (P07379) - Overview - Molecular Target Synopsis

Protein


Pck1, Phosphoenolpyruvate carboxykinase, cytosolic [GTP]
Enzyme Classification 4.1.1.32
UniProt P07379

Also Known as PCKGC_RAT, Pck1

Regulates cataplerosis and anaplerosis, the processes that control the levels of metabolic intermediates in the citric acid cycle. At low glucose levels, it catalyzes the cataplerotic conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. At high glucose levels, it catalyzes the anaplerotic conversion of phosphoenolpyruvate to oxaloacetate. Monomer.

5V9H
STRUCTURE OF THE H477R VARIANT OF RAT CYTOSOLIC PEPCK IN COMPLEX WITH PHOSPHOGLYCOLATE AND GDP.
RCSB/PDB
Inspect Structure
See all 3D Structures for Pck1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
622P07379-1

Sub-cellular localization


UniProt: Pck1 is active in the following subcellular-locations: cytoplasm.
GO terms: Pck1 is active in the following subcellular-locations: cytoplasm, cytosol, mitochondrion.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project Pck1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For Pck1 there are:
41 structures (53 chains) solved
38 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

Pck1 is solved in complex with the approved drug(s):

PPF/FOSCARNET (2RK8_A, 2RK8_B).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


Pck1 has been screened with 18 compounds (23 bioactivities). (see details)