Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

C8G (P07360) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 14/05/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 14/05/2019)


Chains assessed9
Chains with at least one site assessed as druggable using the strict criteria9
Chains with at least one site assessed as druggable using the relaxed criteria9


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
6H04_E Complement component C8 gamma chain Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.8 73.1 33.4 Yes Yes
2 empty 2.39 69.1 24.6 No No
3 empty 2.01 60.3 16.9 No No
4 empty 2.53 66.8 11.6 No No
5 empty 2.08 76.3 9.3 No No
6 empty 2.03 68.5 10.3 No No
7 empty 2.28 61.6 9.1 No No
8 empty 2.05 69.9 11.9 No No
9 empty 2.35 60.3 11.8 No No
10 empty 2.06 64.8 9.7 No No
2OVA_A Complement component C8 gamma chain Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.89 71.2 29.2 Yes Yes
2 empty 2.32 63.9 26.2 No No
3 empty 2.46 61.8 19.9 No No
4 empty 1.88 65.9 15.7 No No
5 empty 2 63.3 12.1 No No
6 empty 2.32 78.7 10.7 No No
7 empty 1.97 65.4 10.8 No No
8 empty 1.94 69.7 9.2 No No
9 empty 1.94 66.9 14.2 No No
10 empty 2.24 61.3 7.5 No No
3OJY_C Complement component C8 gamma chain Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.6 69.8 33 Yes Yes
2 empty 2.42 66.5 24.9 No No
3 empty 2.27 65.7 14.9 No No
4 empty 2.01 80.5 12.8 No No
5 empty 2.44 51.1 13.2 No No
6 empty 2.32 63.2 10.4 No No
7 empty 1.85 77.2 11.6 No No
8 empty 1.93 63.1 15.4 No No
9 empty 2.45 63 11.8 No No
10 empty 2.07 71.8 8.5 No No
2OVD_A Complement component C8 gamma chain Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.89 72.6 31.8 Yes Yes
2 empty 2.45 68.5 25.3 No No
3 empty 2.34 61.9 13.6 No No
4 empty 2.13 69.8 13.4 No No
5 empty 2.39 76.4 9.2 No No
6 empty 2.35 57.6 11.9 No No
7 empty 2.2 71.4 11.5 No No
8 empty 1.96 74.5 13.4 No No
9 empty 2.75 56.7 14.3 No No
10 empty 1.79 74.6 8.3 No No
2RD7_C Complement component C8 gamma chain Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.81 66.7 39.7 Yes Yes
2 empty 2.42 63.9 26.7 No No
3 empty 2.27 66.4 12.2 No No
4 empty 1.79 56.8 13.8 No No
5 empty 1.95 69.4 8.1 No No
6 empty 2.37 60.9 8.3 No No
7 empty 2.36 72.5 6.4 No No
8 empty 2.44 53.8 8.4 No No
9 empty 2.75 58.6 10.5 No No
10 empty 2.6 56.7 8.9 No No
2QOS_C Complement component C8 gamma chain Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.77 69.1 41 Yes Yes
2 empty 2.33 64.8 25.9 No No
3 empty 2.14 60.9 28.7 No No
4 empty 1.77 72.9 13.6 No No
5 empty 1.92 65.5 12.6 No No
6 empty 1.75 73.5 9.8 No No
7 empty 2.56 65 12.6 No No
8 empty 2.3 75.4 7.5 No No
9 empty 2.13 69.8 10.5 No No
10 empty 2.89 54.9 8.8 No No
1IW2_A Complement component C8 gamma chain Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.04 68.8 33.4 Yes Yes
2 empty 2.25 66.7 25.5 No No
3 empty 2.59 63.8 15.7 No No
4 empty 2.22 66.2 11.4 No No
5 empty 1.69 67.2 12.3 No No
6 empty 1.95 70 10.8 No No
7 empty 1.94 59.9 11.4 No No
8 empty 2.29 71.4 8 No No
9 empty 1.97 68.4 9.1 No No
10 empty 1.94 68.7 7.6 No No
1LF7_A Complement component C8 gamma chain Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.07 68.3 39.4 Yes Yes
2 empty 2.29 66.2 25.5 No No
3 empty 1.89 65.1 15 No No
4 empty 2.12 63.7 12.6 No No
5 empty 2.05 67.7 11.6 No No
6 empty 2.13 73.3 11.2 No No
7 empty 1.86 68.4 8.9 No No
8 empty 1.88 69.4 9.3 No No
9 empty 2.34 62.6 7 No No
10 empty 2.97 53.8 9.1 No No
2OVE_A Complement component C8 gamma chain Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.93 72.1 24.5 Yes Yes
2 empty 2.34 70 25.2 No No
3 empty 2.35 73.5 13.9 No No
4 empty 2.39 57.7 13.3 No No
5 empty 2.4 63.8 9.8 No No
6 empty 1.96 66.9 10.4 No No
7 empty 2.42 78.4 11.4 No No
8 empty 2.48 52.6 10.5 No No
9 empty 1.94 56.1 11.5 No No
10 empty 2.39 58.7 7.8 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed7
Domains assessed as druggable using the strict criteria7
Domains assessed as druggable using the relaxed criteria7

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
1IW2_A (71468) Complement component C8 gamma chain Lipocalins, Lipocalins, Retinol binding protein-like 1.9Å Yes Yes
1LF7_A (73878) Complement component C8 gamma chain Lipocalins, Lipocalins, Retinol binding protein-like .6Å Yes Yes
2OVA_A (3170089) Complement component C8 gamma chain Lipocalins, Lipocalins, UNMATCHED 1.3Å Yes Yes
2OVD_A (3170094) Complement component C8 gamma chain Lipocalins, Lipocalins, UNMATCHED 1.75Å Yes Yes
2OVE_A (3170095) Complement component C8 gamma chain Lipocalins, Lipocalins, UNMATCHED 2Å Yes Yes
2QOS_C (3190466) Complement component C8 gamma chain Lipocalins, Lipocalins, UNMATCHED 1.81Å Yes Yes
2RD7_C (3200495) Complement component C8 gamma chain Lipocalins, Lipocalins, UNMATCHED 2.15Å Yes Yes
Ligand-based Druggability Score: -3
Ligand-based Druggability Score Percentile: 59%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


C8G is involved in 1 interactions in the network.


Druggability
Overall Druggability Percentile: 65.62
Druggability for Cancer Therapeutics: 35.28
Druggability for Other Therapeutics: 70.31
Cancer-Associated
Cancer-associated percentile : 16.51
Network Articulation Point
Is C8G critical for communication in the network?


Detailed Graph Legend:Help