FES (P07332) - Overview - Molecular Target Synopsis
FES, Tyrosine-protein kinase Fes/Fps
Enzyme Classification 220.127.116.11
Also Known as FES_HUMAN, FES, FPS
Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts down-stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signaling. Plays a role in cell scattering and cell migration in response to HGF-induced activation of EZR. Phosphorylates BCR and down-regulates BCR kinase activity. Phosphorylates HCLS1/HS1, PECAM1, STAT3 and TRIM28. Homooligomer. Interacts with BCR. Interacts (when activated, via coiled coil domain) with TRIM28. Interacts (via SH2 domain) with phosphorylated EZR, MS4A2/FCER1B and HCLS1/HS1. Interacts with phosphorylated KIT. Interacts with FLT3. Interacts (via F-BAR domain) with soluble tubulin. Interacts (via SH2 domain) with microtubules.
|Protein Length||Ensembl Gene||Ensembl Transcript||Ensembl Protein||Uniprot Isoform|
|694||ENSG00000182511||ENST00000450438, ENST00000414248||ENSP00000409915, ENSP00000414629||P07332-2|
UniProt: FES is active in the following subcellular-locations: cell junction, cell membrane, cytoplasm, cytoplasmic vesicle, cytoskeleton, cytosol, focal adhesion, golgi apparatus.
GO terms: FES is active in the following subcellular-locations: cytoplasm, cytoplasmic vesicle, cytosol, extrinsic component of cytoplasmic side of plasma membrane, focal adhesion, Golgi apparatus, microtubule cytoskeleton.