Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
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Gene Expression
Gene Copy Number Variation
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DST1 (P07273) - Overview - Molecular Target Synopsis

Protein


DST1, Transcription elongation factor S-II
UniProt P07273

Also Known as TFS2_YEAST, DST1, PPR2

Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus., Can promote the transfer of one strand of a double-stranded DNA molecule to a homologous single strand and thus may be involved in recombination.

5FMF
THE P-LOBE OF RNA POLYMERASE II PRE-INITIATION COMPLEX
RCSB/PDB
Inspect Structure
See all 3D Structures for DST1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
309P07273-1

Sub-cellular localization


UniProt: DST1 is active in the following subcellular-locations: nucleus.
GO terms: DST1 is active in the following subcellular-locations: nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project DST1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For DST1 there are:
8 structures (8 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis