Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

TH (P07101) - Overview - Molecular Target Synopsis

Protein


TH, Tyrosine 3-monooxygenase
Enzyme Classification 1.14.16.2
UniProt P07101

Also Known as TY3H_HUMAN, TH, TYH

Plays an important role in the physiology of adrenergic neurons.

4J6S
8 RESIDUE FRAGMENT OF
N-TERMINAL MOTIF OF TYROSINE HYDROXYLASE
IN THE STRUCTURE OF
14-3-3GAMMA COMPLEXED WITH THE N-TERMINAL SEQUENCE OF TYROSINE HYDROXYLASE (RESIDUES 1-43)
RCSB/PDB
Inspect Structure
See all 3D Structures for TH

Isoforms / Transcripts (Protein Coding)


Drugs


TH is targeted by Approved Drug Metyrosine. (see details)
Metyrosine

Sub-cellular localization


Gene Copy Number Variation


In COSMIC - Cell Lines Project TH has gain in 0 cell-lines, loss in 2 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: NCI_ADR_RES, OVCAR_8, PC_3

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: KELLY, CHP-212, PK-59

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For TH there are:
2 structures (8 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


TH has been screened with 8 compounds (8 bioactivities), 1 compounds have bioactivities that show binding affinity of <= 500nM (1 bioactivities). (see details)