Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

LIPF (P07098) - Overview - Molecular Target Synopsis

Protein


LIPF, Gastric triacylglycerol lipase
Enzyme Classification 3.1.1.3
UniProt P07098

Also Known as LIPG_HUMAN, LIPF


1HLG
CRYSTAL STRUCTURE OF HUMAN GASTRIC LIPASE
RCSB/PDB
Inspect Structure
See all 3D Structures for LIPF

Isoforms / Transcripts (Protein Coding)


Drugs


LIPF is targeted by Approved Drug Orlistat. (see details)
Orlistat

Sub-cellular localization


UniProt: LIPF is active in the following subcellular-locations: secreted.
GO terms: LIPF is active in the following subcellular-locations: extracellular region, intracellular membrane-bounded organelle, mitochondrion.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project LIPF has gain in 0 cell-lines, loss in 7 cell-lines and no signal in 998 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MCF7, HL_60, SK_OV_3

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, NCI-H209, LN-18

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For LIPF there are:
1 structures (2 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


LIPF has been screened with 2 compounds (3 bioactivities). (see details)