Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
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RNAi
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prfB (P07012) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 03/09/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 03/09/2019)


Chains assessed3
Chains with at least one site assessed as druggable using the strict criteria1
Chains with at least one site assessed as druggable using the relaxed criteria2


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
5U4J_v Peptide chain release factor RF2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.19 63.6 35.8 Yes No
2 empty 2.32 61.4 18.2 No No
3 empty 2.45 58.5 20.2 No No
4 empty 1.75 63.2 12.6 No No
5 empty 2.59 64.1 9.8 No No
6 empty 1.54 68.1 8.6 No No
7 empty 2.66 69.1 9 No No
8 empty 2.61 66.7 6.2 No No
9 empty 2.64 60.9 11.2 No No
10 empty 2.18 54.3 9.1 No No
1GQE_A Peptide chain release factor RF2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.45 69.1 50.8 Yes Yes
2 empty 1.87 69 45.3 No No
3 empty 1.97 76.2 20.3 No No
4 empty 2.36 64.5 21.9 No No
5 empty 2.29 57.5 20.1 No No
6 empty 2.7 71 13.6 No No
7 empty 2.51 56.5 26.9 No No
8 empty 2.52 69.1 9.7 No No
9 empty 2.3 58.3 13.8 No No
10 empty 2.48 63.6 9.7 No No
6C4H_v Peptide chain release factor RF2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.44 63.1 18.2 No No
2 empty 2.7 63.6 11.6 No No
3 empty 1.96 67.8 11.4 No No
4 empty 2.22 58.1 15.5 No No
5 empty 2.94 50 8.6 No No
6 empty 2.8 53.3 7 No No
7 empty 2.74 56.8 6.9 No No
8 empty 2.54 53.1 8.2 No No
9 empty 2.38 54.4 6.2 No No
10 empty 2.83 63.7 6.4 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed1
Domains assessed as druggable using the strict criteria1
Domains assessed as druggable using the relaxed criteria1

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
1GQE_A (70351) Peptide chain release factor RF2 Release factor, Release factor, Release factor 1.8Å Yes Yes
Ligand-based Druggability Score:
Ligand-based Druggability Score Percentile: %
Ligand-based Druggability Help: Help




		
This protein has no network-based druggability score