Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PROK (P06873) - Overview - Molecular Target Synopsis

Protein


PROK, Proteinase K
Enzyme Classification 3.4.21.64
UniProt P06873

Also Known as PRTK_PARAQ, PROK

Hydrolyzes keratin at aromatic and hydrophobic residues.

6MH6
HIGH-VISCOSITY INJECTOR-BASED PINK BEAM SERIAL CRYSTALLOGRAPHY OF MICRO-CRYSTALS AT A SYNCHROTRON RADIATION SOURCE.
RCSB/PDB
Inspect Structure
See all 3D Structures for PROK

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
384P06873-1

Gene Copy Number Variation


In COSMIC - Cell Lines Project PROK has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For PROK there are:
88 structures (88 chains) solved
12 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

PROK is solved in complex with the approved drug(s):

COU/COUMARIN (2PWB_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


PROK has been screened with 3 compounds (8 bioactivities). (see details)