Molecular Target Synopsis
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ITGAV (P06756) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 02/07/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 02/07/2019)


Chains assessed26
Chains with at least one site assessed as druggable using the strict criteria21
Chains with at least one site assessed as druggable using the relaxed criteria26


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
5FFO_A Integrin alpha-V Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.79 76 46.4 Yes Yes
2 empty 2.19 65.7 28.8 No No
3 bound 2.47 71.3 22.9 No No
4 empty 2.13 65.1 29.6 No No
5 empty 2.35 64 30.9 No No
6 empty 2.69 59.3 22.7 No No
7 empty 2.3 69.2 24.9 No No
8 empty 2.34 65.9 18.1 No No
9 empty 2.51 64.4 19.5 No No
10 empty 2.07 60.6 18.9 No No
1L5G_A Integrin alpha-V Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2 57 41.3 Yes No
2 empty 1.8 78.6 36.4 No No
3 empty 2.05 56.5 28.7 No No
4 empty 2.07 69.1 20.4 No No
5 bound 2.04 67.6 16.6 No No
6 empty 2.39 56.7 27.9 No No
7 empty 2.24 64.6 21.1 No No
8 empty 2.36 64.2 20.5 No No
9 empty 2.02 60.7 17.7 No No
10 empty 2.2 69.8 13.9 No No
5NET_A Integrin alpha-V Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.69 81.3 35.9 Yes Yes
2 bound 2.18 66.2 33.7 No No
3 empty 2.03 64.8 17 No No
4 empty 2.13 59.7 14.6 No No
5 empty 2.18 66.7 14.3 No No
6 empty 2.32 58.2 14.6 No No
7 empty 2.31 67.5 16.5 No No
8 empty 1.84 65.9 12.9 No No
9 empty 2.35 63.9 13.6 No No
10 empty 2.49 59.7 17.1 No No
4UM9_A Integrin alpha-V Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.75 81.5 36.4 Yes Yes
2 empty 2.24 67.8 17.6 No No
3 empty 2.26 57.5 26.1 No No
4 empty 1.94 63.9 18 No No
5 bound 2.07 69.1 22.5 No No
6 empty 2.21 67.4 15.9 No No
7 empty 1.93 57.7 14.9 No No
8 bound 2.11 53.3 15 No No
9 empty 2 54.1 17.3 No No
10 empty 1.82 67.6 11.8 No No
4G1E_A Integrin alpha-V Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.12 57.1 43.4 Yes No
2 empty 1.52 77.2 45.9 Yes No
3 empty 2.17 61.7 35.3 No No
4 empty 2.46 64.7 26.7 No No
5 bound 2.34 63.4 33.6 No No
6 empty 2.48 67.6 31.1 No No
7 empty 2.35 67.3 21 No No
8 empty 2.53 66 27.3 No No
9 empty 2.13 71.9 24.7 No No
10 empty 2.34 68.6 16.5 No No
3IJE_A Integrin alpha-V Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.14 53.7 51.4 Yes No
2 empty 1.62 77.1 38.2 Yes No
3 empty 2.27 58.7 35.6 No No
4 bound 2.22 64.6 21.2 No No
5 empty 1.94 60.2 21.1 No No
6 empty 2.28 74.4 17.4 No No
7 empty 2.2 57.7 25.8 No No
8 bound 2 62.3 17.3 No No
9 empty 2.28 65.5 17.2 No No
10 empty 2.04 64.7 17.9 No No
5NER_A Integrin alpha-V Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.6 82.5 35.4 Yes Yes
2 bound 2.13 65.2 33.5 No No
3 empty 2.02 64.4 18 No No
4 empty 2.07 62.8 20 No No
5 empty 2.21 58.2 14.7 No No
6 empty 2.11 59.6 14.9 No No
7 empty 2.18 65.2 14.8 No No
8 empty 2.49 61.2 16.2 No No
9 empty 1.97 54 15.7 No No
10 empty 2.39 61.8 13.8 No No
1M1X_A Integrin alpha-V Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.65 77.4 40.5 Yes Yes
2 bound 2.06 49.9 54.9 No No
3 empty 2.13 69.4 18.9 No No
4 bound 2.02 66.7 16 No No
5 empty 2.11 56.6 27 No No
6 empty 2.4 62.6 24.7 No No
7 empty 2.11 58 28.4 No No
8 empty 2.14 64 17.3 No No
9 empty 1.83 61.1 16.7 No No
10 empty 2.76 60.1 19.4 No No
4O02_A Integrin alpha-V Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.98 72.3 115.5 Yes Yes
2 empty 1.63 71.2 42.2 No No
3 empty 1.52 77.2 44.8 No No
4 empty 2 76.1 19.2 No No
5 empty 2.18 66.5 32.2 No No
6 empty 1.88 59.4 21.6 No No
7 empty 2.32 65.4 24.4 No No
8 empty 2.32 66.3 19.5 No No
9 bound 2.37 67.5 17 No No
10 bound 1.91 71.2 17.2 No No
5NEM_A Integrin alpha-V Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.59 81.3 36.4 Yes Yes
2 bound 2.22 63.4 34 No No
3 empty 2.03 62.5 17.2 No No
4 empty 2.21 60.5 14.6 No No
5 empty 2.14 58.1 15.1 No No
6 empty 2.23 61.4 14.3 No No
7 empty 1.93 66.9 13.2 No No
8 empty 2.1 62.6 14.1 No No
9 empty 2.46 58.2 15.2 No No
10 empty 2.11 61.6 14.9 No No
6AVU_A Integrin alpha-V Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.62 73.7 53.4 Yes Yes
2 empty 1.99 73.1 58.7 No No
3 empty 1.04 74.3 42 No No
4 empty 1.54 78.2 44.8 No No
5 empty 1.76 73.8 38.5 No No
6 empty 1.78 75.6 24.6 No No
7 empty 1.64 93.6 25 Yes No
8 empty 1.81 70.2 19.4 No No
9 empty 1.8 77.4 17.4 No No
10 empty 1.76 75.5 18 No No
5FFG_A Integrin alpha-V Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.62 81.1 36.4 Yes Yes
2 bound 2.07 71 14.6 No No
3 empty 2.1 57.9 21.1 No No
4 empty 2.43 58.6 16.2 No No
5 empty 2.03 52.2 19.7 No No
6 empty 2.18 66.5 11.9 No No
7 empty 2.06 67.3 15 No No
8 empty 2.02 66.2 13.9 No No
9 empty 1.94 52.9 16.8 No No
10 bound 2.33 61.1 10.9 No No
1JV2_A Integrin alpha-V Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.25 53.8 44.4 Yes No
2 empty 1.95 69.5 30.3 No No
3 empty 1.76 90.8 21.3 Yes No
4 empty 2.3 66.9 27.1 No No
5 empty 2.48 60.3 30.7 No No
6 bound 2.04 68.4 15.8 No No
7 empty 2.13 67.4 17.8 No No
8 empty 2.19 65.8 18.7 No No
9 empty 2.26 55.3 22.4 No No
10 empty 2.33 59.2 19.8 No No
4UM8_C Integrin alpha-V Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.47 81.6 37.9 Yes Yes
2 bound 2.07 62.1 33.9 No No
3 empty 2.18 60.6 22.4 No No
4 empty 1.82 61.1 18 No No
5 empty 2 57.8 17.2 No No
6 empty 2.2 61.3 28.3 No No
7 empty 2.39 61.3 18.8 No No
8 empty 2.03 62 15.3 No No
9 empty 2.18 65.5 13.7 No No
10 empty 2.2 67 14.6 No No
4UM9_C Integrin alpha-V Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.67 81.6 35.6 Yes Yes
2 empty 1.99 62.3 24 No No
3 empty 2.17 65.8 20.7 No No
4 empty 2.58 61.9 22.4 No No
5 bound 2.02 65.1 18.4 No No
6 empty 2.16 59.3 21.3 No No
7 empty 2.27 68.8 16 No No
8 empty 2.04 70.7 13.6 No No
9 empty 2.09 64.4 16.1 No No
10 bound 2.52 59.7 14.5 No No
6AVQ_A Integrin alpha-V Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.64 76.2 68.4 Yes Yes
2 empty 1.18 74.7 43 Yes No
3 empty 1.93 78.3 57.6 No No
4 empty 1.6 74.7 44.3 No No
5 empty 1.78 86.2 24.4 Yes No
6 empty 1.72 75.5 38.8 No No
7 empty 1.97 71.7 23.4 No No
8 empty 1.83 65.2 24.6 No No
9 empty 1.82 77.6 16.6 No No
10 empty 1.5 61.2 21.1 No No
6AVR_A Integrin alpha-V Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.64 75.2 54.8 Yes Yes
2 empty 1.76 78 44.8 No No
3 empty 1.03 75.8 40.5 No No
4 empty 1.8 76.6 56.6 No No
5 empty 1.7 74.8 38.1 No No
6 empty 1.63 92 23.9 Yes No
7 empty 1.83 69.2 23.2 No No
8 empty 1.65 65.7 21.8 No No
9 empty 1.88 77.3 16.5 No No
10 empty 1.68 76.4 11.4 No No
5NEU_A Integrin alpha-V Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.56 77.4 50.1 Yes Yes
2 empty 2.23 70.3 27.4 No No
3 empty 2.22 70.9 18.4 No No
4 empty 2.31 61.4 22.6 No No
5 empty 2.06 70.5 15.5 No No
6 empty 2.04 66.6 19.6 No No
7 empty 2.53 64.5 15.9 No No
8 empty 2.36 65.1 14.3 No No
9 empty 2.47 63.8 16.3 No No
10 empty 2.29 70.1 13.7 No No
6DJP_A Integrin alpha-V Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.67 75.7 66.6 Yes Yes
2 empty 1.84 84.4 36.2 Yes Yes
3 empty 1.61 83.7 25.7 No No
4 bound 1.84 71.6 26.6 No No
5 empty 1.8 71.2 17.8 No No
6 empty 2.03 85 22.7 Yes No
7 empty 1.76 65.7 21.8 No No
8 empty 1.9 82.2 20.3 No No
9 empty 1.72 60.4 15.9 No No
10 empty 1.71 55.7 13.6 No No
4UM8_A Integrin alpha-V Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.73 80 36.4 Yes Yes
2 bound 2.23 62.7 34.3 No No
3 empty 2.02 65.4 27 No No
4 empty 2.07 57.8 17 No No
5 empty 1.98 62.7 21 No No
6 bound 2.28 59.5 16.7 No No
7 empty 2.11 60.7 15.1 No No
8 empty 2.05 64.4 16.1 No No
9 empty 2.22 65.4 14.6 No No
10 empty 1.72 58.8 15.3 No No
4MMY_A Integrin alpha-V Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.21 57.3 50 Yes No
2 empty 1.72 76.2 50 Yes No
3 bound 2.14 67.2 40.5 No No
4 empty 2.39 67.2 40 No No
5 empty 2.28 65.6 26.8 No No
6 empty 2.38 60.9 26.7 No No
7 empty 2.15 73.3 16.7 No No
8 empty 2.12 70.2 17.5 No No
9 empty 2.04 60.7 18.6 No No
10 empty 2.6 62.6 17.6 No No
5FFO_E Integrin alpha-V Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.72 76.1 35.2 Yes Yes
2 empty 2.04 62.2 27 No No
3 empty 2.42 53.7 24.6 No No
4 bound 1.99 69.6 17.2 No No
5 empty 1.54 66.4 14 No No
6 empty 2.1 62 18 No No
7 empty 1.82 66.5 20.1 No No
8 empty 2.3 61.5 15.7 No No
9 empty 1.92 60.6 23.4 No No
10 empty 2.19 61.4 17.6 No No
4MMX_A Integrin alpha-V Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.12 57.3 54.8 Yes No
2 empty 1.78 80.9 36.3 Yes Yes
3 bound 2.11 62.7 27 No No
4 empty 2.09 61.6 25.4 No No
5 empty 2.29 58.2 27.2 No No
6 empty 2.16 65.6 13.7 No No
7 empty 2.16 63.4 13.7 No No
8 empty 2.04 64.9 18.9 No No
9 empty 2.64 57.9 19.4 No No
10 empty 1.9 54.8 13 No No
4G1M_A Integrin alpha-V Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.76 55 51.5 Yes No
2 empty 1.72 79.2 36.7 Yes Yes
3 bound 2.25 65.5 21.1 No No
4 empty 2.25 66.8 26.6 No No
5 bound 2.27 62.8 23.6 No No
6 empty 2.15 56.6 19.8 No No
7 empty 1.96 60.7 22.2 No No
8 empty 2.16 62.7 17.6 No No
9 empty 2.31 62.1 19.4 No No
10 empty 2.34 65.7 21.7 No No
1U8C_A Integrin alpha-V Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.56 78 43.2 Yes Yes
2 empty 2.16 52.3 41 No No
3 empty 2.18 60.8 40 No No
4 bound 2.09 68.4 16.1 No No
5 empty 2.02 62.1 28.8 No No
6 empty 2.41 68.5 20.8 No No
7 bound 1.91 59.2 21.6 No No
8 empty 2.05 69.1 16 No No
9 empty 1.97 57.3 22.9 No No
10 empty 2.24 61.1 16 No No
4MMZ_A Integrin alpha-V Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.82 79.9 36.5 Yes Yes
2 bound 1.97 45.6 31.3 No No
3 bound 2.23 62.4 34.5 No No
4 bound 2.09 61.5 34.9 No No
5 empty 2.13 61.5 37.9 No No
6 empty 2.21 63.4 22.9 No No
7 empty 2.1 66.9 20.8 No No
8 empty 1.98 62.3 19.4 No No
9 empty 1.88 70.1 17.6 No No
10 empty 1.95 61.7 17.2 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed20
Domains assessed as druggable using the strict criteria6
Domains assessed as druggable using the relaxed criteria17

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
1JV2_A (67334) Integrin alpha-V Immunoglobulin-like beta-sandwich, Integrin domains, Integrin domains 3.1Å Yes No
1JV2_A (67335) Integrin alpha-V Immunoglobulin-like beta-sandwich, Integrin domains, Integrin domains 3.1Å Yes No
1JV2_A (67336) Integrin alpha-V Immunoglobulin-like beta-sandwich, Integrin domains, Integrin domains 3.1Å Yes No
1JV2_A (67337) Integrin alpha-V 7-bladed beta-propeller, Integrin alpha N-terminal domain, Integrin alpha N-terminal domain 3.1Å Yes Yes
1L5G_A (73581) Integrin alpha-V Immunoglobulin-like beta-sandwich, Integrin domains, Integrin domains 3.2Å Yes No
1L5G_A (73582) Integrin alpha-V Immunoglobulin-like beta-sandwich, Integrin domains, Integrin domains 3.2Å Yes No
1L5G_A (73583) Integrin alpha-V Immunoglobulin-like beta-sandwich, Integrin domains, Integrin domains 3.2Å Yes No
1L5G_A (73584) Integrin alpha-V 7-bladed beta-propeller, Integrin alpha N-terminal domain, Integrin alpha N-terminal domain 3.2Å Yes Yes
1M1X_A (74425) Integrin alpha-V 7-bladed beta-propeller, Integrin alpha N-terminal domain, Integrin alpha N-terminal domain 3.3Å Yes Yes
1M1X_A (74422) Integrin alpha-V Immunoglobulin-like beta-sandwich, Integrin domains, Integrin domains 3.3Å No No
1M1X_A (74424) Integrin alpha-V Immunoglobulin-like beta-sandwich, Integrin domains, Integrin domains 3.3Å Yes No
1M1X_A (74423) Integrin alpha-V Immunoglobulin-like beta-sandwich, Integrin domains, Integrin domains 3.3Å No No
1U8C_A (113119) Integrin alpha-V 7-bladed beta-propeller, Integrin alpha N-terminal domain, Integrin alpha N-terminal domain 3.1Å Yes Yes
1U8C_A (113116) Integrin alpha-V Immunoglobulin-like beta-sandwich, Integrin domains, Integrin domains 3.1Å No No
1U8C_A (113117) Integrin alpha-V Immunoglobulin-like beta-sandwich, Integrin domains, Integrin domains 3.1Å Yes No
1U8C_A (113118) Integrin alpha-V Immunoglobulin-like beta-sandwich, Integrin domains, Integrin domains 3.1Å Yes Yes
3IJE_A (3470997) Integrin alpha-V 7-bladed beta-propeller, Integrin alpha N-terminal domain, UNMATCHED 2.9Å Yes Yes
3IJE_A (3470999) Integrin alpha-V Immunoglobulin-like beta-sandwich, Integrin domains, UNMATCHED 2.9Å Yes No
3IJE_A (3470998) Integrin alpha-V Immunoglobulin-like beta-sandwich, Integrin domains, UNMATCHED 2.9Å Yes No
3IJE_A (3471000) Integrin alpha-V Immunoglobulin-like beta-sandwich, Integrin domains, UNMATCHED 2.9Å Yes No
Ligand-based Druggability Score: 1.45
Ligand-based Druggability Score Percentile: 94%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


ITGAV is involved in 29 interactions in the network.


Druggability
Overall Druggability Percentile: 87.43
Druggability for Cancer Therapeutics: 71.23
Druggability for Other Therapeutics: 93.05
Cancer-Associated
Cancer-associated percentile : 74.72
Network Articulation Point
Is ITGAV critical for communication in the network?


Detailed Graph Legend:Help