Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PYGL (P06737) - Overview - Molecular Target Synopsis

Protein


PYGL, Glycogen phosphorylase, liver form
Enzyme Classification 2.4.1.1
UniProt P06737

Also Known as PYGL_HUMAN, PYGL

Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. Homodimer. Dimers associate into a tetramer to form the enzymatically active phosphorylase A. Interacts with PPP1R3B.

3DD1
CRYSTAL STRUCTURE OF GLYCOGEN PHOPHORYLASE COMPLEXED WITH AN ANTHRANILIMIDE BASED INHIBITOR GSK254
RCSB/PDB
Inspect Structure
See all 3D Structures for PYGL

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


Gene Copy Number Variation


In COSMIC - Cell Lines Project PYGL has gain in 4 cell-lines, loss in 0 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MDA_MB_231, PC_3, SK_OV_3

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: KP4, OCI-AML2, OVMANA

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHEK, HMEC, SK-N-SH

(see details)

3D Structures


For PYGL there are:
18 structures (34 chains) solved
18 are solved in complex with at least one small molecule ligand
7 are solved with an approved drug

PYGL is solved in complex with the approved drug(s):

CFF/CAFFEINE (1L5Q_A, 1L5Q_B, 1L7X_A, 1L7X_B, 3DD1_A, 3DD1_B, 3DDS_A, 3DDS_B, 3DDW_A, 3DDW_B),
RBF/RIBOFLAVIN (1L5R_A),
AMP/ADENOSINE PHOSPHATE (1FA9_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


PYGL has been screened with 800 compounds (1121 bioactivities), 327 compounds have bioactivities that show binding affinity of <= 500nM (493 bioactivities). (see details)