Molecular Target Synopsis
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FCER2 (P06734) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 02/07/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 02/07/2019)


Chains assessed88
Chains with at least one site assessed as druggable using the strict criteria1
Chains with at least one site assessed as druggable using the relaxed criteria18


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
4J6Q_A Low affinity immunoglobulin epsilon Fc receptor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.15 63.7 19.8 No No
2 empty 2.01 63.7 15.1 No No
3 empty 2.43 63.1 15.2 No No
4 empty 2.57 61.7 11.4 No No
5 empty 2.37 65.3 8.7 No No
6 empty 2.5 62.1 8.1 No No
7 empty 2.26 51.9 9.4 No No
8 empty 2.56 68.5 6.8 No No
9 empty 2.2 66.7 8.7 No No
10 empty 2.16 65.9 5.8 No No
4GJX_G Low affinity immunoglobulin epsilon Fc receptor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.05 64 16.4 No No
2 empty 2.04 61.8 19.8 No No
3 empty 2.29 66.7 19.9 No No
4 empty 1.87 62.3 15.5 No No
5 empty 2.3 64.4 9.7 No No
6 empty 2.14 63 11.9 No No
7 empty 2.67 64.2 11.7 No No
8 empty 2.11 50.3 9.9 No No
9 empty 3.21 75.9 5.6 No No
10 empty 2.31 66.9 8.2 No No
4J6P_D Low affinity immunoglobulin epsilon Fc receptor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.12 65.1 19.7 No No
2 empty 2.06 63.1 28.6 No No
3 empty 1.96 68.6 14.2 No No
4 empty 1.97 65.7 14.1 No No
5 empty 2.61 63.9 11.8 No No
6 empty 2.2 71.5 7.4 No No
7 empty 2.47 63.3 12 No No
8 empty 2.33 62.2 7.8 No No
9 empty 2.06 60.2 11.5 No No
10 empty 2.51 68.3 10 No No
4GKO_I Low affinity immunoglobulin epsilon Fc receptor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.18 58.7 20.3 No No
2 empty 2.06 60.6 17 No No
3 empty 2.65 68.1 17.8 No No
4 empty 2.31 61.1 12.5 No No
5 empty 2.03 64.3 12.2 No No
6 empty 2.25 58.9 12 No No
7 empty 2.27 59.2 11.4 No No
8 empty 2.52 53.3 15.2 No No
9 empty 2.63 68.8 7.5 No No
10 empty 1.24 54 9.3 No No
4GK1_F Low affinity immunoglobulin epsilon Fc receptor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.92 62.6 19.4 No No
2 bound 2.6 54.4 11.2 No No
3 empty 2.18 63.9 13.4 No No
4 empty 1.97 64.8 10.6 No No
5 bound 2.32 61.3 8.5 No No
6 empty 2.24 65.3 9.9 No No
7 empty 2.78 60.5 11.1 No No
8 empty 2.5 71.6 8.8 No No
9 empty 2.6 62.9 8.9 No No
10 empty 2.39 66.3 9.1 No No
5LGK_E Low affinity immunoglobulin epsilon Fc receptor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.47 67.6 16.7 No No
2 empty 2.15 66.1 12.9 No No
3 empty 2.09 62.9 12.6 No No
4 empty 2.5 60.5 16.8 No No
5 empty 1.89 68.9 7.3 No No
6 empty 2.67 58.1 16.6 No No
7 empty 2.74 60.6 12.3 No No
8 empty 2.13 74 10.5 No No
9 empty 2.37 62.8 9.8 No No
10 empty 2.06 65.1 12.1 No No
4J6M_H Low affinity immunoglobulin epsilon Fc receptor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.21 64.6 22.3 No No
2 empty 2.11 65 22.2 No No
3 empty 2.46 64.5 15.1 No No
4 empty 2.57 60.2 10.8 No No
5 empty 2.81 74.8 7.5 No No
6 empty 2.24 66 9.1 No No
7 empty 2.58 62.3 8.3 No No
8 empty 2.59 68.5 5.5 No No
9 empty 2.73 65 5.7 No No
10 empty 2.63 62.3 6 No No
4G9A_A Low affinity immunoglobulin epsilon Fc receptor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.31 65.8 21.3 No No
2 empty 2.12 64 22.9 No No
3 empty 2.69 73.8 13.5 No No
4 empty 2.01 59.9 17.6 No No
5 empty 2.85 74.6 8.6 No No
6 empty 2.48 66.9 8.1 No No
7 empty 2.65 61.3 8 No No
8 empty 2.77 63.3 8.2 No No
9 empty 2.11 60.2 11 No No
10 empty 2.5 57.7 7.7 No No
4G9A_D Low affinity immunoglobulin epsilon Fc receptor Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.05 61.5 24.3 Yes No
2 empty 2.02 65 16.5 No No
3 empty 2.57 62.9 17.4 No No
4 empty 2.5 64.3 10.2 No No
5 empty 2.25 63.8 11.5 No No
6 empty 2.38 57.6 11.3 No No
7 empty 2.6 69.6 11.2 No No
8 empty 2.86 67.6 8.4 No No
9 empty 2.23 58 8.9 No No
10 empty 2.46 53.1 8.6 No No
4GJX_B Low affinity immunoglobulin epsilon Fc receptor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.1 66.9 15.9 No No
2 empty 1.83 63 17.7 No No
3 empty 2.01 64.6 17 No No
4 empty 1.83 65 12.8 No No
5 empty 2.3 61.1 10.4 No No
6 empty 2.57 61.2 10.6 No No
7 empty 2.31 65.4 8.1 No No
8 empty 2.15 51.1 10.2 No No
9 empty 1.97 64.2 7.8 No No
10 empty 2.76 60 8.2 No No
2H2R_B Low affinity immunoglobulin epsilon Fc receptor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.98 61.5 16.3 No No
2 empty 1.95 65.1 17.2 No No
3 empty 2.37 62.6 9.9 No No
4 empty 2.56 67 10.8 No No
5 empty 2.33 77.5 9.9 No No
6 empty 2.15 62.8 11.6 No No
7 empty 2.47 55.2 8.9 No No
8 empty 2 65.6 7.6 No No
9 empty 2.35 58.6 6.5 No No
10 empty 2.71 55.1 8.5 No No
4EZM_H Low affinity immunoglobulin epsilon Fc receptor Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.24 64.7 27.2 Yes No
2 empty 2.1 60 22.8 No No
3 empty 2.49 66.1 15.5 No No
4 empty 2.12 66.7 16.7 No No
5 empty 2.37 58.4 14.2 No No
6 empty 2.21 58.2 12.3 No No
7 empty 2.14 65.7 8.2 No No
8 empty 2.52 58.9 11.3 No No
9 empty 2.25 61.6 8.7 No No
10 empty 2.23 65.6 8.5 No No
4GK1_A Low affinity immunoglobulin epsilon Fc receptor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.19 64.3 21.7 No No
2 bound 2.55 61.3 21.4 No No
3 empty 2.36 63.6 17 No No
4 empty 2.63 55.9 11.1 No No
5 empty 1.91 64.4 12.3 No No
6 empty 2.74 63.4 10.4 No No
7 empty 2.12 69.4 10.8 No No
8 empty 2.2 60.5 9.9 No No
9 empty 2.33 52.7 15.1 No No
10 bound 2.06 61.8 8.5 No No
4EZM_J Low affinity immunoglobulin epsilon Fc receptor Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.33 64.6 24.6 Yes No
2 empty 2.3 64.4 13.8 No No
3 empty 2.22 59.2 22 No No
4 empty 2.55 59.9 12.9 No No
5 empty 2.2 56.6 12.8 No No
6 empty 1.57 57.7 11.2 No No
7 empty 2.59 60.5 11.8 No No
8 empty 2.08 69.2 9.8 No No
9 empty 2.72 67.8 6.8 No No
10 empty 2.38 67.4 8.6 No No
4J6L_E Low affinity immunoglobulin epsilon Fc receptor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.97 66.8 15.9 No No
2 empty 2.44 64.6 16.8 No No
3 empty 1.76 63.9 12.8 No No
4 empty 2.04 68.6 8.5 No No
5 empty 2.57 57.4 10.2 No No
6 empty 1.79 66.2 8.4 No No
7 empty 2.16 63 12.1 No No
8 empty 2.05 65.7 8.6 No No
9 empty 2.54 57.6 7.6 No No
10 empty 2.31 57.3 7.5 No No
4J6J_A Low affinity immunoglobulin epsilon Fc receptor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.05 62.2 19.2 No No
2 empty 2.01 60.3 18.3 No No
3 empty 2.29 71.7 15.4 No No
4 empty 2.72 62.1 10 No No
5 empty 2.18 63.2 12.1 No No
6 empty 2.44 62.9 8.5 No No
7 empty 2.3 59.7 10.7 No No
8 empty 2.35 70.6 7.6 No No
9 empty 2.97 48.6 7.8 No No
10 empty 2.2 74 6.7 No No
4J6M_C Low affinity immunoglobulin epsilon Fc receptor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.87 65.1 17.3 No No
2 empty 2.07 62.3 19.6 No No
3 empty 2.22 73.6 14.4 No No
4 empty 2.06 63.3 17.6 No No
5 empty 2.62 59.7 11.5 No No
6 empty 2.67 68.7 6.5 No No
7 empty 2.74 50 8.2 No No
8 empty 1.9 73.9 10 No No
9 empty 2.69 60 7.1 No No
10 empty 2.29 63.3 6.8 No No
4J6K_D Low affinity immunoglobulin epsilon Fc receptor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.09 62.9 23.4 No No
2 empty 2.07 63.5 16.8 No No
3 empty 2.42 67.2 13.2 No No
4 empty 2.52 61.7 10.8 No No
5 empty 2.18 65.5 8.7 No No
6 empty 2.87 66.5 7.5 No No
7 empty 2.24 61.2 7.7 No No
8 empty 2.12 63.6 6 No No
9 empty 1.78 60.6 7.5 No No
10 empty 3.07 66.7 6.8 No No
4G96_C Low affinity immunoglobulin epsilon Fc receptor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.71 65.2 21.9 No No
2 empty 2.15 59.4 15.9 No No
3 empty 2.46 66 13.5 No No
4 empty 2.93 64 7.9 No No
5 empty 2.4 60.5 12.5 No No
6 empty 2.88 65.5 7.3 No No
7 empty 1.99 61.5 7.3 No No
8 empty 2.27 53.6 8.6 No No
9 empty 3.05 61.3 7.1 No No
10 empty 2.55 60.4 6.7 No No
4EZM_I Low affinity immunoglobulin epsilon Fc receptor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.32 64.6 23.1 No No
2 empty 1.93 60.7 19.6 No No
3 empty 2.01 64.3 22.4 No No
4 empty 2.33 65.1 13.6 No No
5 empty 2.37 58.7 12.5 No No
6 empty 2.39 70 8.8 No No
7 empty 2.11 70.2 8.6 No No
8 empty 2.72 62.9 9.5 No No
9 empty 2.79 73.1 8.7 No No
10 empty 2.42 57.4 8.4 No No
4G96_D Low affinity immunoglobulin epsilon Fc receptor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.99 63.5 23.4 No No
2 empty 2.05 60.5 15.7 No No
3 empty 2.46 66.1 12.9 No No
4 empty 2.2 61.3 12.3 No No
5 empty 2.51 63.5 8.4 No No
6 empty 2.85 54.5 11.6 No No
7 empty 3.14 67.7 8.9 No No
8 empty 1.87 60.1 9 No No
9 empty 2.82 59.9 10 No No
10 empty 2.23 70.3 7.3 No No
4J6J_D Low affinity immunoglobulin epsilon Fc receptor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.93 65 22 No No
2 empty 2.07 62.7 19.8 No No
3 empty 2.67 66.3 13.2 No No
4 empty 2.52 58.6 10.5 No No
5 empty 2.19 64 7.8 No No
6 empty 2.83 71.2 5.7 No No
7 empty 2.36 51.4 8.4 No No
8 empty 1.15 57.7 7.9 No No
9 empty 2.89 70.4 9.2 No No
10 empty 3.04 62.7 6.6 No No
4GJX_E Low affinity immunoglobulin epsilon Fc receptor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.05 62.9 17.7 No No
2 empty 1.91 66 17.9 No No
3 empty 1.94 61.2 17.4 No No
4 empty 1.81 64.5 13.1 No No
5 empty 2.32 60.1 10.9 No No
6 empty 2.43 62.4 10.8 No No
7 empty 2.17 71.1 10.5 No No
8 empty 2.7 57.5 13.4 No No
9 empty 2.81 56.1 11.5 No No
10 empty 1.94 58.7 10.5 No No
4GJX_C Low affinity immunoglobulin epsilon Fc receptor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.04 64.6 22.1 No No
2 empty 2.11 64.2 23 No No
3 empty 2.38 64.7 19.5 No No
4 empty 1.71 67 10.1 No No
5 empty 2.3 61.9 10.3 No No
6 empty 2.55 60 11.8 No No
7 empty 2.31 68.8 7.9 No No
8 empty 1.73 60.8 6.8 No No
9 empty 2.71 71.5 7 No No
10 empty 2.28 49.7 9.6 No No
4J6L_H Low affinity immunoglobulin epsilon Fc receptor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.03 61.9 16.9 No No
2 empty 1.92 67 16.5 No No
3 empty 2.41 65.5 16.3 No No
4 empty 2.54 56.4 12.1 No No
5 empty 2.55 68.4 11 No No
6 empty 2.09 65 6.1 No No
7 empty 2.34 60.4 9.7 No No
8 empty 2.34 64.5 6.9 No No
9 empty 3.03 74 6.4 No No
10 empty 2.4 60.3 9.2 No No
4GJ0_B Low affinity immunoglobulin epsilon Fc receptor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.01 63.6 20.7 No No
2 empty 2.28 62.6 17.8 No No
3 empty 2.34 65.6 17.4 No No
4 empty 2.1 62 12.8 No No
5 empty 2.71 63.3 9.1 No No
6 empty 2.46 60.9 8.3 No No
7 empty 2.78 65 11.3 No No
8 empty 1.92 64.6 10.2 No No
9 empty 2.31 66.3 8.4 No No
10 empty 2.44 59.2 8.5 No No
4G9A_C Low affinity immunoglobulin epsilon Fc receptor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.37 64 17.1 No No
2 empty 1.89 62.2 21.8 No No
3 empty 2.1 75.9 13 No No
4 empty 2.58 57.1 10.6 No No
5 empty 2.7 69.8 9 No No
6 empty 2.42 59.3 11.1 No No
7 empty 2.4 64.2 8.4 No No
8 empty 2.18 63 7.2 No No
9 empty 2.42 60.9 8.1 No No
10 empty 2.36 56.8 8.1 No No
4J6K_A Low affinity immunoglobulin epsilon Fc receptor Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.14 64.3 24.8 Yes No
2 empty 2.02 62.6 20.9 No No
3 empty 2.55 60.8 15.6 No No
4 empty 2.28 69.8 9.2 No No
5 empty 2.74 61.7 8.5 No No
6 empty 2.46 66.8 10.1 No No
7 empty 2.94 52.3 10.8 No No
8 empty 2.19 58 9.1 No No
9 empty 2.74 65.4 9.3 No No
10 empty 3.01 60.3 9 No No
4EZM_G Low affinity immunoglobulin epsilon Fc receptor Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.41 65.1 25.9 Yes No
2 empty 2 64.4 26 No No
3 empty 2.08 64.7 20.3 No No
4 empty 2.4 67.4 13.1 No No
5 empty 2.35 61.8 14.9 No No
6 empty 1.56 54.8 10.7 No No
7 empty 2.69 51.1 10.6 No No
8 empty 2.59 58.9 8.3 No No
9 empty 2.84 70.8 8.8 No No
10 empty 2.43 60.5 8.7 No No
4J6M_F Low affinity immunoglobulin epsilon Fc receptor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.09 61 16.3 No No
2 empty 1.81 63.1 19.2 No No
3 empty 2.57 67.9 17.5 No No
4 empty 2.72 61.1 9.6 No No
5 bound 2.76 62 16.2 No No
6 empty 2.2 73.2 9.3 No No
7 empty 2.92 53.7 8.3 No No
8 empty 2.36 66.3 10 No No
9 empty 2.21 64.2 9.2 No No
10 empty 2.1 64.3 0 No No
1T8D_A Low affinity immunoglobulin epsilon Fc receptor Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.36 62.8 41 Yes No
2 empty 2.57 62.9 27.1 No No
3 empty 2.46 56 19.4 No No
4 empty 2.23 54.7 13.5 No No
5 empty 2.08 63.6 12.1 No No
6 empty 1.42 49.8 10.2 No No
7 empty 2.5 55.4 11.5 No No
8 empty 2.4 67.6 12.3 No No
9 empty 2.66 68.2 11 No No
10 empty 1.88 58.9 10.9 No No
4GJ0_D Low affinity immunoglobulin epsilon Fc receptor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.08 63 23.6 No No
2 empty 1.89 66.9 18 No No
3 empty 2.35 60.2 13.4 No No
4 empty 2.2 65.2 11.9 No No
5 empty 2.41 60.9 8.5 No No
6 empty 2.93 58.9 11.9 No No
7 empty 2.75 55.5 7.6 No No
8 empty 2.58 69.1 7.2 No No
9 empty 2.89 66.2 8.7 No No
10 empty 2.18 62.9 7.5 No No
4KI1_G Low affinity immunoglobulin epsilon Fc receptor Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.17 64.5 25.7 Yes No
2 empty 2.17 61.6 30.6 No No
3 empty 2.25 67.6 17 No No
4 empty 2.63 67.8 14.2 No No
5 empty 2.22 58.4 12.1 No No
6 empty 2.34 73.3 8.3 No No
7 empty 2.08 58 9.4 No No
8 empty 2.93 82.3 7.2 No No
9 empty 2.5 57.9 8.2 No No
10 empty 2.51 67.7 8.3 No No
4J6J_C Low affinity immunoglobulin epsilon Fc receptor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.07 62.5 18.1 No No
2 empty 2.15 63.4 22.3 No No
3 empty 2.42 62.5 15.4 No No
4 empty 2.46 60.4 9.7 No No
5 empty 2.19 62.8 11.3 No No
6 empty 2.51 49.5 11.6 No No
7 empty 1.78 70.1 6.9 No No
8 empty 2.71 64.3 12 No No
9 empty 2.37 63.3 8.4 No No
10 empty 2.46 53.6 9.2 No No
4GKO_L Low affinity immunoglobulin epsilon Fc receptor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.07 63.2 19.1 No No
2 empty 2.11 57.8 19.4 No No
3 empty 2.49 67.7 17.1 No No
4 empty 2.18 61.9 13.4 No No
5 empty 2.54 60.2 11.6 No No
6 empty 2.34 60.4 12 No No
7 empty 2.34 57.7 16.3 No No
8 empty 2.12 61.1 12.9 No No
9 empty 1.76 55.7 11.6 No No
10 empty 2.68 71.4 8.8 No No
4J6K_G Low affinity immunoglobulin epsilon Fc receptor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.95 63.2 23.5 No No
2 empty 2.16 63.5 22.9 No No
3 empty 2.34 66.2 12.7 No No
4 empty 2.52 65.2 10.9 No No
5 empty 2.29 60.5 14.3 No No
6 empty 2.2 62.2 7.5 No No
7 empty 2.37 66.3 8.9 No No
8 empty 2.63 63.9 9.9 No No
9 empty 2.45 54.7 8.9 No No
10 empty 2.26 73.7 0 No No
2H2T_B Low affinity immunoglobulin epsilon Fc receptor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.14 62.2 20 No No
2 empty 1.86 60.4 16.8 No No
3 empty 2.11 61.4 10 No No
4 empty 2.28 64.5 11.4 No No
5 empty 1.96 56.2 11.5 No No
6 empty 2.77 60.4 11.2 No No
7 empty 2.76 68.9 8.3 No No
8 empty 2.37 58.6 14.8 No No
9 empty 2.27 64 11.1 No No
10 empty 2.2 70.6 6 No No
4J6K_E Low affinity immunoglobulin epsilon Fc receptor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.37 62 17.2 No No
2 empty 2.04 62.4 23 No No
3 empty 2.13 63.2 18.8 No No
4 empty 2.56 63.6 10.5 No No
5 empty 2.2 69 10.2 No No
6 empty 2.35 59.8 11.2 No No
7 empty 2.67 69.8 8.6 No No
8 empty 2.36 61.2 8.1 No No
9 empty 2.23 56.6 6.9 No No
10 empty 2.82 67.8 6.4 No No
4J6L_A Low affinity immunoglobulin epsilon Fc receptor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.38 63 16 No No
2 empty 2.03 63.9 16 No No
3 empty 1.75 66.6 12.5 No No
4 empty 2.38 56.9 12.7 No No
5 empty 1.97 68.3 11.7 No No
6 empty 1.64 70.8 7.8 No No
7 empty 2.09 60.9 7.6 No No
8 empty 2.38 64.6 8.1 No No
9 empty 2.23 65 6.1 No No
10 empty 2.2 59 7.5 No No
4GKO_H Low affinity immunoglobulin epsilon Fc receptor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.26 63 23 No No
2 empty 2.19 55.2 23.1 No No
3 empty 2.35 60.4 18.7 No No
4 empty 2.53 67.8 18.6 No No
5 empty 2.25 59.3 11.6 No No
6 empty 2.54 57.3 16.2 No No
7 empty 2.35 58.2 9.4 No No
8 empty 1.78 51 9.8 No No
9 empty 2.1 62.3 7.5 No No
10 empty 2.12 63.4 7 No No
4KI1_E Low affinity immunoglobulin epsilon Fc receptor Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.31 65.1 25.3 Yes No
2 empty 2.04 62.4 22 No No
3 empty 2.09 61.8 17.5 No No
4 empty 2.48 69.1 12.8 No No
5 empty 2.53 60.2 12.3 No No
6 empty 2.12 72.4 10.1 No No
7 empty 2.26 61.7 8.8 No No
8 empty 2.15 63 9.3 No No
9 empty 2.94 67.5 7.5 No No
10 empty 2.46 60.8 8.1 No No
4G96_A Low affinity immunoglobulin epsilon Fc receptor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.83 65.1 22.2 No No
2 empty 2.14 63.6 16.8 No No
3 empty 2.37 69.5 19.5 No No
4 empty 2.64 62.7 9.3 No No
5 empty 1.89 71.2 6.6 No No
6 empty 2.74 66.7 7.6 No No
7 empty 2.55 64.8 6.3 No No
8 empty 2.35 71.9 8.5 No No
9 empty 2.24 60.4 7.1 No No
10 empty 2.9 71.5 6.5 No No
4GJX_H Low affinity immunoglobulin epsilon Fc receptor Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.24 62 25.5 Yes No
2 empty 2.08 63 19.2 No No
3 empty 1.96 65.3 17.4 No No
4 empty 1.7 62.7 10.4 No No
5 empty 2.33 60.6 9 No No
6 empty 2.55 63.3 11.3 No No
7 empty 2.34 61.7 9.2 No No
8 empty 2.79 59.2 9.4 No No
9 empty 1.66 63.5 7.8 No No
10 empty 1.86 66.2 6.8 No No
4GJ0_A Low affinity immunoglobulin epsilon Fc receptor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.11 63.3 21.1 No No
2 empty 2.28 68.6 15.8 No No
3 empty 2.16 67.7 10.4 No No
4 empty 2.28 63 10.6 No No
5 empty 1.89 60.5 12.6 No No
6 empty 2.32 58.3 12.3 No No
7 empty 2.95 61.1 12.5 No No
8 empty 2.78 60.8 9.9 No No
9 empty 2.17 74.5 7.3 No No
10 empty 2.79 50.6 10 No No
4GKO_J Low affinity immunoglobulin epsilon Fc receptor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.18 57.8 19.9 No No
2 empty 2.19 63.5 19.9 No No
3 empty 2.31 60.6 12 No No
4 empty 2.4 63.8 16 No No
5 empty 2.26 62.8 14.6 No No
6 empty 2.33 53.9 16.5 No No
7 empty 2.31 60.7 11.1 No No
8 empty 2.42 58.5 10.9 No No
9 empty 2.23 71.8 7 No No
10 empty 2.59 72.9 7.8 No No
4J6N_B Low affinity immunoglobulin epsilon Fc receptor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.9 64.4 16.7 No No
2 empty 1.85 63.5 18.5 No No
3 empty 2.6 60.3 11 No No
4 empty 1.92 63.6 10.3 No No
5 empty 2.36 68.1 14.3 No No
6 empty 2.43 55.1 16.7 No No
7 empty 1.61 65.1 8.1 No No
8 empty 2.36 64.4 9.3 No No
9 empty 2.22 63.4 7.3 No No
10 empty 3.08 71.6 6.4 No No
1T8C_A Low affinity immunoglobulin epsilon Fc receptor Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.16 62.3 24.9 Yes No
2 empty 2.7 64.1 23.5 No No
3 empty 2.22 50.6 17.4 No No
4 empty 2.63 64.7 20.2 No No
5 empty 2.48 60 15 No No
6 empty 2.68 67.7 13.8 No No
7 empty 2.12 57.1 12.7 No No
8 empty 2.74 67.9 10.3 No No
9 empty 2.03 62.8 13 No No
10 empty 2.43 58.4 18.1 No No
5LGK_F Low affinity immunoglobulin epsilon Fc receptor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.39 66.3 12.9 No No
2 empty 2.1 69.6 15.2 No No
3 empty 2.5 62.6 14.8 No No
4 empty 2.55 54.2 18.1 No No
5 empty 2.49 62.4 14.3 No No
6 empty 2.21 68.7 9.1 No No
7 empty 2.4 64.3 11.1 No No
8 empty 2.01 68.8 12.2 No No
9 empty 2.41 65.3 9.5 No No
10 empty 2.32 65.3 8.9 No No
4J6M_E Low affinity immunoglobulin epsilon Fc receptor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.04 64.9 19.2 No No
2 empty 2.25 65.5 24.4 No No
3 empty 2.48 54.6 17.5 No No
4 empty 2.6 57.5 10.5 No No
5 empty 2.9 66.4 8.5 No No
6 empty 2.19 61.5 9.4 No No
7 empty 2.52 59.4 8.9 No No
8 empty 2.09 66.9 8.1 No No
9 empty 2.05 64.6 6 No No
10 empty 2.69 77.3 7.9 No No
4GI0_C Low affinity immunoglobulin epsilon Fc receptor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.77 62.5 17.5 No No
2 empty 2.36 62.8 20.4 No No
3 empty 1.88 62.9 17.2 No No
4 empty 2.07 66.9 14.4 No No
5 empty 2.21 54.7 11.2 No No
6 empty 2.6 61.6 16.3 No No
7 empty 2.5 62.9 7.9 No No
8 empty 2.51 62 15.2 No No
9 empty 2.15 55.4 9.8 No No
10 empty 2.01 67.3 7.2 No No
4J6K_F Low affinity immunoglobulin epsilon Fc receptor Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.12 60.3 29.1 Yes No
2 empty 2.09 64.1 18.4 No No
3 empty 2.51 64.7 15.8 No No
4 empty 2.76 63.7 9.1 No No
5 empty 2.15 55.1 12.5 No No
6 empty 2.16 66.7 6.1 No No
7 empty 3.07 73 9.9 No No
8 empty 2.68 52.3 7.5 No No
9 empty 1.8 58.1 8.1 No No
10 empty 2.11 71.4 7.8 No No
4GK1_E Low affinity immunoglobulin epsilon Fc receptor Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.87 59.3 24.5 Yes No
2 bound 2.4 68.2 20.4 No No
3 bound 2.29 60.3 17.1 No No
4 empty 2.08 60.1 10.9 No No
5 empty 2.43 52 12.8 No No
6 empty 1.92 69.7 9.7 No No
7 empty 2.1 61.3 9.3 No No
8 empty 2.25 62.7 8.7 No No
9 empty 2.8 68.3 5.2 No No
10 empty 2.06 53.9 8.6 No No
4GJ0_C Low affinity immunoglobulin epsilon Fc receptor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.77 67.1 19.8 No No
2 empty 2.55 64.6 13.6 No No
3 empty 2.72 62.8 10 No No
4 empty 2.31 59 13.5 No No
5 empty 2.14 58.6 9.6 No No
6 empty 2.46 65.1 7.6 No No
7 empty 2.7 61.3 8.6 No No
8 empty 2.77 63.3 6.2 No No
9 empty 2.36 58.6 7.5 No No
10 empty 2.31 51.3 7.7 No No
4J6L_F Low affinity immunoglobulin epsilon Fc receptor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.06 62.2 16.4 No No
2 empty 1.85 66.8 18.1 No No
3 empty 2.26 58.7 15.7 No No
4 empty 2.54 57.2 8.4 No No
5 empty 2.35 57.1 9.7 No No
6 empty 1.49 64.2 7.6 No No
7 empty 2.46 62.5 10.1 No No
8 empty 2.34 56 9.3 No No
9 empty 2.46 66.9 7.9 No No
10 empty 2.22 70 2.4 No No
4J6L_B Low affinity immunoglobulin epsilon Fc receptor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.02 63.6 17.2 No No
2 empty 2.45 67.4 13.8 No No
3 empty 2.31 55.7 13.1 No No
4 empty 1.97 63.3 14.4 No No
5 empty 1.93 70.7 9.3 No No
6 empty 1.66 63.9 8.8 No No
7 empty 2.35 66.5 6.7 No No
8 empty 2.89 71.2 7.2 No No
9 empty 2.44 66.9 5.9 No No
10 empty 2.17 67.2 5.9 No No
4J6J_B Low affinity immunoglobulin epsilon Fc receptor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.09 64 21.9 No No
2 empty 2.01 62.7 19.1 No No
3 empty 2.34 61.1 18 No No
4 empty 2.33 64.8 18 No No
5 empty 2.44 62.3 9.6 No No
6 empty 2.39 58 9.5 No No
7 empty 2.07 58.4 9.9 No No
8 empty 2.64 68.3 9.6 No No
9 empty 2.11 64.8 6.8 No No
10 empty 2.15 64.2 11.2 No No
4GK1_B Low affinity immunoglobulin epsilon Fc receptor Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.22 72.6 18 Yes No
2 empty 2.33 64.2 12.2 No No
3 empty 1.85 54.5 12.9 No No
4 empty 2.21 63.3 16.4 No No
5 empty 2.47 49.8 12.8 No No
6 empty 2.52 56.7 10.6 No No
7 empty 1.66 68.8 7.5 No No
8 empty 2.2 57.9 9.1 No No
9 empty 2.06 57.2 11.4 No No
10 empty 2.33 52.3 11.5 No No
4J6P_C Low affinity immunoglobulin epsilon Fc receptor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.29 62.2 23.4 No No
2 empty 2.11 63.9 21.5 No No
3 empty 2.24 69.9 13.6 No No
4 empty 1.91 67.9 14.1 No No
5 empty 2.29 63.6 7.8 No No
6 empty 2.49 60 8.4 No No
7 empty 2.59 70.8 9 No No
8 empty 2.48 66.7 9.5 No No
9 empty 1.5 57.8 8.7 No No
10 empty 2.31 65.1 8.5 No No
4EZM_L Low affinity immunoglobulin epsilon Fc receptor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.15 61.8 23.5 No No
2 empty 2.09 65.9 18.3 No No
3 empty 2.07 67.3 15.5 No No
4 empty 2.29 62.3 14.4 No No
5 empty 2.43 57.3 13.2 No No
6 empty 2.39 61.4 8.6 No No
7 empty 2.72 71.8 9.4 No No
8 empty 2.24 62.8 7.5 No No
9 empty 2.21 68.8 8.8 No No
10 empty 2.2 68.5 8.2 No No
4GK1_G Low affinity immunoglobulin epsilon Fc receptor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.39 61.7 22.9 No No
2 bound 1.98 61.5 13.1 No No
3 empty 2.3 60.6 9.1 No No
4 empty 2.14 63.1 15.9 No No
5 empty 2.11 68.1 12.1 No No
6 empty 1.83 61.5 8.8 No No
7 empty 2.61 56.9 9.7 No No
8 bound 2.75 66.3 7.5 No No
9 empty 1.95 65 10.4 No No
10 empty 2.33 64.1 11.4 No No
2H2R_A Low affinity immunoglobulin epsilon Fc receptor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.02 64.6 15.5 No No
2 empty 1.82 65.7 19.8 No No
3 empty 2.53 59 11.6 No No
4 empty 2.59 61.8 20.2 No No
5 empty 2.33 64.5 9.3 No No
6 empty 2.27 79 9.5 No No
7 empty 2.24 70.6 9.1 No No
8 empty 2.23 63.3 9.8 No No
9 empty 1.59 61.6 9 No No
10 empty 2.31 57.9 6.4 No No
4J6M_A Low affinity immunoglobulin epsilon Fc receptor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.88 63.6 18.3 No No
2 empty 2.47 68.5 17.5 No No
3 empty 1.93 67.5 14.8 No No
4 empty 2.06 63.6 18 No No
5 empty 2.36 60.3 12.3 No No
6 empty 2.57 64.8 6 No No
7 empty 2.25 67.6 8.4 No No
8 empty 2.18 78.8 9.3 No No
9 empty 2.23 61.1 11.8 No No
10 empty 2.59 62.8 6.2 No No
4J6L_C Low affinity immunoglobulin epsilon Fc receptor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.01 65.9 16.5 No No
2 empty 2.28 64.2 16.7 No No
3 empty 2.3 55.7 12.9 No No
4 empty 1.74 63.4 13.4 No No
5 empty 1.8 69.2 9.1 No No
6 empty 2.26 63 10.3 No No
7 empty 2.41 66.5 10.5 No No
8 empty 2.04 70.7 6 No No
9 empty 2.49 67.1 7.6 No No
10 empty 2.73 77 9.3 No No
4J6M_B Low affinity immunoglobulin epsilon Fc receptor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.18 65.7 22.9 No No
2 empty 2.07 62.9 16.7 No No
3 empty 2.21 65.4 17 No No
4 empty 1.94 60.4 15.9 No No
5 empty 2.71 61.2 9.9 No No
6 empty 2.07 74.2 8.1 No No
7 empty 2.3 63.4 7.9 No No
8 empty 2.62 57.3 12.4 No No
9 empty 2.83 68.2 9.2 No No
10 empty 2.22 59.5 8.3 No No
4GJX_A Low affinity immunoglobulin epsilon Fc receptor Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.05 60 25.4 Yes No
2 empty 2.01 64.3 17.8 No No
3 empty 1.9 66.7 16.1 No No
4 empty 1.86 62.3 13.8 No No
5 empty 2.28 57.9 10.4 No No
6 empty 2.55 59.2 10.3 No No
7 empty 2.11 65 12 No No
8 empty 2.47 65.7 7.5 No No
9 empty 2.28 62 8.2 No No
10 bound 2.32 65.6 6.2 No No
4GK1_C Low affinity immunoglobulin epsilon Fc receptor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.19 65.8 22.5 No No
2 empty 2.14 59 18.7 No No
3 empty 2.29 61.1 15.3 No No
4 bound 2.34 62.9 16.5 No No
5 empty 1.98 59.5 15.8 No No
6 empty 2.54 52.8 11.4 No No
7 empty 2.55 64.1 7.7 No No
8 empty 2.12 69.5 9.5 No No
9 empty 1.94 57.4 11.8 No No
10 empty 2.49 57.6 9.1 No No
4J6M_G Low affinity immunoglobulin epsilon Fc receptor Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.16 60.7 24 Yes No
2 empty 2.16 66 23.9 No No
3 empty 2.35 63.5 16.8 No No
4 empty 2.56 55.9 11.1 No No
5 empty 2.33 61.8 7.7 No No
6 empty 2.41 66.1 5.5 No No
7 empty 2.85 80 8.4 No No
8 empty 2.32 69.3 8.6 No No
9 empty 2.03 62.9 9.4 No No
10 empty 2.19 62.3 9.2 No No
4J6P_A Low affinity immunoglobulin epsilon Fc receptor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.09 62.4 16.1 No No
2 empty 1.81 61.5 20.8 No No
3 empty 2.49 62.1 19.5 No No
4 empty 1.71 63.8 8 No No
5 empty 2.52 63.5 9.1 No No
6 empty 2.28 62.4 9.4 No No
7 empty 2.36 64.6 8.9 No No
8 empty 2.36 59.4 7.7 No No
9 empty 2.27 66.8 7.5 No No
10 empty 2.34 60.7 9.3 No No
4J6K_B Low affinity immunoglobulin epsilon Fc receptor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.93 68.3 18.4 No No
2 empty 2.07 61.8 17 No No
3 empty 1.96 62.6 19.9 No No
4 empty 2.5 65.5 11.3 No No
5 empty 2.49 52.1 10.9 No No
6 empty 2.83 64.8 8 No No
7 empty 2.16 58.6 7.6 No No
8 empty 2.22 76.2 9.2 No No
9 empty 2.34 65.6 8.5 No No
10 empty 2.79 70.1 8 No No
4GK1_D Low affinity immunoglobulin epsilon Fc receptor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.73 64 16.6 No No
2 empty 2.4 53.1 12.6 No No
3 empty 2.36 61.6 15.3 No No
4 empty 2.04 59.3 14.4 No No
5 empty 2.53 63.3 11.8 No No
6 empty 2.31 63.4 10.3 No No
7 bound 2.41 62.8 11 No No
8 empty 2.62 61.1 8.7 No No
9 empty 2.08 49 9.1 No No
10 empty 2.07 53.8 8.4 No No
4KI1_H Low affinity immunoglobulin epsilon Fc receptor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.21 63.5 23.5 No No
2 empty 2.07 62.1 23.4 No No
3 empty 2.45 63.7 14.8 No No
4 empty 2.09 64.6 20 No No
5 empty 2.59 60.9 12.2 No No
6 empty 2.31 58.9 11.9 No No
7 empty 2.37 63.9 9.4 No No
8 empty 2.07 74.1 9.3 No No
9 empty 1.95 65.1 9.1 No No
10 empty 2.95 71.7 8.5 No No
4G96_B Low affinity immunoglobulin epsilon Fc receptor Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.35 66.2 18.3 Yes Yes
2 empty 2.1 62 26.6 No No
3 empty 1.84 68 17.4 No No
4 empty 1.99 65.6 13.8 No No
5 empty 2.22 63.6 11.4 No No
6 empty 2.78 50.5 11 No No
7 empty 2.54 55.5 10.7 No No
8 empty 2.16 66.2 7.6 No No
9 empty 2.46 66 10 No No
10 empty 2.36 57.1 7 No No
4J6L_D Low affinity immunoglobulin epsilon Fc receptor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.13 63.3 15.6 No No
2 empty 1.68 61.7 15.9 No No
3 empty 2.45 63.4 15.2 No No
4 empty 2.56 59.1 13 No No
5 empty 1.6 69.3 7.9 No No
6 empty 2.4 66.1 5.6 No No
7 empty 2.1 64.2 7 No No
8 empty 2.71 73.2 8 No No
9 empty 3.01 82.5 6.4 No No
10 empty 2.03 61.2 8.2 No No
4KI1_F Low affinity immunoglobulin epsilon Fc receptor Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.4 65.4 27.4 Yes No
2 empty 2.23 69 20.4 No No
3 empty 2.11 62.4 18.4 No No
4 empty 2.51 58.7 12.7 No No
5 empty 2.18 57.3 11.3 No No
6 empty 2.58 58.6 15.4 No No
7 empty 2.16 60.6 9.4 No No
8 empty 2.02 70.2 6.9 No No
9 empty 2.16 68.4 8.3 No No
10 empty 2.89 69.6 7.6 No No
4EZM_K Low affinity immunoglobulin epsilon Fc receptor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.32 65.6 23 No No
2 empty 2.31 59.3 23.1 No No
3 empty 2.54 63.7 15 No No
4 empty 2.05 64.3 23 No No
5 empty 2.34 57.2 12.8 No No
6 empty 2.36 56.8 17.2 No No
7 empty 2.06 66 8.8 No No
8 empty 2.18 65.6 8.8 No No
9 empty 2.88 68.5 7.6 No No
10 empty 1.93 55.6 9.9 No No
4GJX_F Low affinity immunoglobulin epsilon Fc receptor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.15 62.6 21.1 No No
2 empty 2.04 63.9 17.3 No No
3 empty 2.25 64.7 22.4 No No
4 empty 1.85 64.6 15.8 No No
5 empty 2.25 57.2 10.2 No No
6 empty 2.54 62.3 11.7 No No
7 empty 2.38 61.8 12.2 No No
8 empty 1.99 59.1 11.1 No No
9 empty 2.29 60.7 9.1 No No
10 empty 2.21 51.2 10.5 No No
4J6P_B Low affinity immunoglobulin epsilon Fc receptor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.98 60.4 15.6 No No
2 empty 1.83 65.1 19.6 No No
3 empty 2.34 63.8 12.6 No No
4 empty 2.29 59.9 11.2 No No
5 empty 2.76 58.8 10.7 No No
6 empty 1.7 63.4 9.3 No No
7 empty 2.1 58.7 10.6 No No
8 empty 2.21 54.8 9 No No
9 empty 2.44 66.3 6.5 No No
10 empty 2.73 68 5.8 No No
4GI0_A Low affinity immunoglobulin epsilon Fc receptor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.16 61.5 23.4 No No
2 empty 2.02 60.8 20 No No
3 empty 2.12 66.3 17.5 No No
4 empty 1.97 59.6 16.3 No No
5 bound 2.4 64.4 15.8 No No
6 empty 2.53 62.1 15.2 No No
7 empty 2.24 63.3 9.4 No No
8 empty 2.42 61.9 8.2 No No
9 empty 2.57 76.7 8.1 No No
10 empty 2.31 56.7 7.7 No No
4G9A_B Low affinity immunoglobulin epsilon Fc receptor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.98 64.9 16.6 No No
2 empty 2.04 56.8 10.9 No No
3 empty 2.63 78 13.1 No No
4 empty 2.18 56.3 11.4 No No
5 empty 2.57 54 11.5 No No
6 empty 1.93 59.7 11.5 No No
7 empty 1.88 59 11.8 No No
8 empty 2.72 61 9.2 No No
9 empty 2.61 68 8.9 No No
10 empty 2.7 64.8 11.7 No No
4J6K_C Low affinity immunoglobulin epsilon Fc receptor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.06 63.4 19.3 No No
2 empty 2.07 62.2 16.6 No No
3 empty 2.26 68.4 15.3 No No
4 empty 2.51 62.1 9.8 No No
5 empty 2.71 62.9 14.6 No No
6 empty 2.03 60.6 14.7 No No
7 empty 2.23 65 7.3 No No
8 empty 2.62 61.6 11.3 No No
9 empty 2.32 66.7 8.5 No No
10 empty 3.04 58.8 9 No No
4GKO_K Low affinity immunoglobulin epsilon Fc receptor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.09 60.2 19.8 No No
2 empty 2.14 59.8 22.5 No No
3 empty 2.36 61.8 11.9 No No
4 empty 1.91 62.2 15.2 No No
5 empty 2.93 77.1 11.1 No No
6 empty 2.24 50.2 16.8 No No
7 empty 2.2 57.9 12.2 No No
8 empty 2.37 55.4 13.3 No No
9 empty 1.97 69.3 8.2 No No
10 empty 2.57 73 8.4 No No
4J6N_A Low affinity immunoglobulin epsilon Fc receptor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.97 65.4 19.5 No No
2 empty 1.96 65.4 17.2 No No
3 empty 2.56 66.8 12.5 No No
4 empty 2.42 54.4 18.7 No No
5 empty 2.32 63.9 12.6 No No
6 empty 2.22 72.2 10.9 No No
7 empty 2.43 62.9 9.4 No No
8 empty 2.23 49.7 8.8 No No
9 empty 2.66 69.6 5.6 No No
10 empty 1.43 62.8 6.2 No No
4GJX_D Low affinity immunoglobulin epsilon Fc receptor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.07 63.8 16.4 No No
2 empty 2.05 63.2 19.6 No No
3 bound 2 63.3 16.4 No No
4 empty 1.85 65 13.5 No No
5 empty 2.29 60.2 10.6 No No
6 empty 2.43 60.4 10 No No
7 empty 2.15 61.9 9.5 No No
8 empty 2.41 68.5 11.9 No No
9 empty 2.6 61.9 9.7 No No
10 empty 2.16 55.6 11 No No
4GKO_G Low affinity immunoglobulin epsilon Fc receptor Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.13 61.6 24.4 Yes No
2 empty 2.15 63.9 24.8 No No
3 empty 2.14 61.6 19.3 No No
4 empty 2.3 61.2 16.6 No No
5 empty 2.23 61.2 11.5 No No
6 empty 2.65 65.9 8.6 No No
7 empty 2.24 60.6 8.8 No No
8 empty 2.4 50.3 9.2 No No
9 empty 2.08 64.8 6.2 No No
10 empty 2.56 61.2 9.2 No No
4J6M_D Low affinity immunoglobulin epsilon Fc receptor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.29 62.7 21.4 No No
2 empty 2.14 65.3 23.5 No No
3 empty 2.3 55.7 17.5 No No
4 empty 2.45 65.4 13.9 No No
5 empty 2.56 56.9 10.8 No No
6 empty 2.66 66.4 9.4 No No
7 empty 2.21 65 6.8 No No
8 empty 2.42 56.4 8.5 No No
9 empty 2.31 57 5.6 No No
10 empty 2.27 71.3 9.4 No No
4GI0_B Low affinity immunoglobulin epsilon Fc receptor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.87 63.9 19.1 No No
2 empty 2.09 65.9 23.3 No No
3 empty 2.26 66.4 16.4 No No
4 empty 2.05 59 17.8 No No
5 empty 2.26 58 13.3 No No
6 empty 2.51 73.3 7.3 No No
7 empty 1.95 59.4 9.9 No No
8 empty 2.43 63.5 8 No No
9 empty 2.34 68 6.7 No No
10 empty 2.44 60.3 8.2 No No
4J6K_H Low affinity immunoglobulin epsilon Fc receptor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.22 68.7 22.7 No No
2 empty 2.52 63.4 15.8 No No
3 empty 2.37 52 17.9 No No
4 empty 2.23 63.8 13.9 No No
5 empty 2.17 59.6 13.9 No No
6 empty 2.62 63.5 17.9 No No
7 empty 2 59.2 9.6 No No
8 empty 1.94 66.2 11.2 No No
9 empty 2.48 60.9 8.2 No No
10 empty 2.25 57.8 9.3 No No
4J6L_G Low affinity immunoglobulin epsilon Fc receptor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.03 65.2 15.8 No No
2 empty 2.32 60.7 13.4 No No
3 empty 2.24 61.3 17.7 No No
4 empty 1.77 63.7 14.3 No No
5 empty 2.5 66.7 12 No No
6 empty 1.65 66.3 7.5 No No
7 empty 2.98 72.8 7.9 No No
8 empty 2.3 63.8 10.8 No No
9 empty 2.17 57.7 7.8 No No
10 empty 2.44 67.2 6.6 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed5
Domains assessed as druggable using the strict criteria0
Domains assessed as druggable using the relaxed criteria3

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
1T8C_A (119170) Low affinity immunoglobulin epsilon Fc receptor C-type lectin-like, C-type lectin-like, C-type lectin domain Yes No
1T8D_A (119171) Low affinity immunoglobulin epsilon Fc receptor C-type lectin-like, C-type lectin-like, C-type lectin domain Yes No
2H2R_A (4158085) Low affinity immunoglobulin epsilon Fc receptor C-type lectin-like, C-type lectin-like, C-type lectin domain (Homo Multimer) 1.5Å Yes No
2H2R_A (3100657) Low affinity immunoglobulin epsilon Fc receptor C-type lectin-like, C-type lectin-like, UNMATCHED 1.5Å No No
2H2R_B (4158085) Low affinity immunoglobulin epsilon Fc receptor C-type lectin-like, C-type lectin-like, C-type lectin domain (Homo Multimer) 1.5Å Yes No
2H2T_B (3100659) Low affinity immunoglobulin epsilon Fc receptor C-type lectin-like, C-type lectin-like, UNMATCHED 1.3Å No No
Ligand-based Druggability Score: 0.3
Ligand-based Druggability Score Percentile: 83%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


FCER2 is involved in 6 interactions in the network.


Druggability
Overall Druggability Percentile: 48.68
Druggability for Cancer Therapeutics: 52.66
Druggability for Other Therapeutics: 82.02
Cancer-Associated
Cancer-associated percentile : 43.57
Network Articulation Point
Is FCER2 critical for communication in the network?


Detailed Graph Legend:Help