Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

FCER2 (P06734) - Overview - Molecular Target Synopsis

Protein


FCER2, Low affinity immunoglobulin epsilon Fc receptor
UniProt P06734

Also Known as FCER2_HUMAN, FCER2, CD23A, CLEC4J, FCE2, IGEBF

Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen). Homotrimer.

5LGK
CRYSTAL STRUCTURE OF THE HUMAN IGE-FC BOUND TO ITS B CELL RECEPTOR DERCD23
RCSB/PDB
Inspect Structure
See all 3D Structures for FCER2

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: FCER2 is active in the following subcellular-locations: cell membrane, secreted.
GO terms: FCER2 is active in the following subcellular-locations: external side of plasma membrane, extracellular exosome, integral component of plasma membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project FCER2 has gain in 0 cell-lines, loss in 1 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: RPMI_8226, MCF7, HL_60

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: COR-L26, SIG-M5, CCRF-SB

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: CD20-positive B cell, GM12878, SK-N-SH

(see details)

3D Structures


For FCER2 there are:
21 structures (88 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


FCER2 has been screened with 88 compounds (92 bioactivities), 39 compounds have bioactivities that show binding affinity of <= 500nM (40 bioactivities). (see details)