Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

btuD (P06611) - Overview - Molecular Target Synopsis

Protein


btuD, Vitamin B12 import ATP-binding protein BtuD
Enzyme Classification 7.6.2.8
UniProt P06611

Also Known as BTUD_ECOLI, btuD

Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system. The complex is composed of two ATP-binding proteins (BtuD), two transmembrane proteins (BtuC) and a solute-binding protein (BtuF).

4R9U
STRUCTURE OF VITAMIN B12 TRANSPORTER BTUCD IN A NUCLEOTIDE-BOUND OUTWARD FACING STATE
RCSB/PDB
Inspect Structure
See all 3D Structures for btuD

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization


UniProt: btuD is active in the following subcellular-locations: cell inner membrane.
GO terms: btuD is active in the following subcellular-locations: ATP-binding cassette (ABC) transporter complex, extrinsic component of membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project btuD has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For btuD there are:
5 structures (12 chains) solved
3 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis