Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
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Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
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Germline Genetics

btuC (P06609) - Overview - Molecular Target Synopsis

Protein


btuC, Vitamin B12 import system permease protein BtuC
UniProt P06609

Also Known as BTUC_ECOLI, btuC

Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane. The complex is composed of two ATP-binding proteins (BtuD), two transmembrane proteins (BtuC) and a solute-binding protein (BtuF).

4R9U
STRUCTURE OF VITAMIN B12 TRANSPORTER BTUCD IN A NUCLEOTIDE-BOUND OUTWARD FACING STATE
RCSB/PDB
Inspect Structure
See all 3D Structures for btuC

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization


UniProt: btuC is active in the following subcellular-locations: cell inner membrane.
GO terms: btuC is active in the following subcellular-locations: ATP-binding cassette (ABC) transporter complex, integral component of plasma membrane, membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project btuC has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For btuC there are:
5 structures (12 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis