Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PTMA (P06454) - Overview - Molecular Target Synopsis

Protein


PTMA, Prothymosin alpha
UniProt P06454

Also Known as PTMA_HUMAN, PTMA, TMSA

Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections. Interacts with NUPR1; regulates apoptotic process.

2MNQ
28 RESIDUE FRAGMENT OF
THYMOSIN ALPHA-1
IN THE STRUCTURE OF
1H, 13C, AND 15N CHEMICAL SHIFT ASSIGNMENTS FOR THYMOSIN ALPHA 1
RCSB/PDB
Inspect Structure
See all 3D Structures for PTMA

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: PTMA is active in the following subcellular-locations: nucleus.
GO terms: PTMA is active in the following subcellular-locations: cytosol, nucleoplasm, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project PTMA has gain in 1 cell-lines, loss in 0 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HL_60, CCRF_CEM, MOLT_4

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: OVKATE, TYK-nu, HCC2157

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, A549, SK-N-SH

(see details)

3D Structures


For PTMA there are:
2 structures (2 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis