Molecular Target Synopsis
Overview
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Drugs and Clinical Candidates
Druggability
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Gene Copy Number Variation
RNAi
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Germline Genetics

gB (P06437) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 08/10/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 08/10/2019)


Chains assessed31
Chains with at least one site assessed as druggable using the strict criteria4
Chains with at least one site assessed as druggable using the relaxed criteria31


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
2GUM_C Envelope glycoprotein B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.07 55.4 91.2 Yes No
2 empty 2.43 66.2 30.3 No No
3 empty 2.13 67.4 28.7 No No
4 empty 2.47 63.6 27.7 No No
5 empty 1.99 68.6 25.3 No No
6 empty 1.95 61.1 21.4 No No
7 empty 2.45 66.1 22.3 No No
8 empty 2.46 52.2 28.4 No No
9 empty 1.5 29.9 16.9 No No
10 empty 1.82 62 19.8 No No
3NW8_C Envelope glycoprotein B Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.45 69.6 29.1 Yes Yes
2 empty 1.19 45.3 53.7 No No
3 bound 2.03 63.3 37.9 No No
4 empty 2.11 61.9 30.7 No No
5 empty 2.16 69 25.3 No No
6 empty 1.97 68.1 17.9 No No
7 bound 2.14 64.9 28.9 No No
8 empty 2.3 70.2 23.4 No No
9 empty 2 67.3 18.6 No No
10 empty 1.49 28.3 21.6 No No
4BOM_A Envelope glycoprotein B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.38 49.4 72.8 Yes No
2 empty 2.06 70.9 38 No No
3 empty 2.39 68.7 31.6 No No
4 empty 1.94 68.1 32.7 No No
5 empty 2.24 70.8 26.5 No No
6 empty 1.93 64.7 24.3 No No
7 empty 2.63 61.3 25.3 No No
8 empty 1.93 62.3 15.8 No No
9 empty 2.32 61.8 20.6 No No
10 empty 1.82 61.9 18.5 No No
4HSI_A Envelope glycoprotein B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.42 45.7 73.4 Yes No
2 empty 2.17 67.5 41.5 No No
3 empty 2.3 64.3 35.5 No No
4 empty 1.95 68.1 28 No No
5 empty 2.54 63.9 30.7 No No
6 empty 2.13 72.8 20.6 No No
7 empty 2.06 64.3 28.7 No No
8 empty 1.88 76.5 24.9 No No
9 empty 2.04 63 15.2 No No
10 empty 2.29 54 16.2 No No
5FZ2_A Envelope glycoprotein B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.9 70 27.2 Yes No
2 empty 2.39 62.1 27.1 No No
3 empty 1.93 69.9 22.2 No No
4 empty 2.19 63.3 27.1 No No
5 empty 2.19 65.5 23.1 No No
6 empty 1.96 71.4 13.9 No No
7 empty 1.72 62.9 18.3 No No
8 empty 2.07 67.3 12.8 No No
9 empty 2.68 65.7 14 No No
10 empty 1.99 55.1 14.4 No No
3NW8_A Envelope glycoprotein B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.26 43.1 70.9 Yes No
2 bound 2.22 65.4 24.9 No No
3 empty 1.97 60.7 30.5 No No
4 empty 2 64.1 25.2 No No
5 empty 1.93 65.8 17.7 No No
6 empty 1.81 62.2 21.4 No No
7 empty 2.02 61.4 20.6 No No
8 bound 2.24 73.6 13 No No
9 empty 1.85 48.5 18.1 No No
10 empty 1.4 33.6 19.6 No No
3NWD_D Envelope glycoprotein B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.3 43.7 72.2 Yes No
2 bound 1.96 67 27.1 No No
3 empty 1.98 63.1 30.3 No No
4 empty 1.99 68 18.2 No No
5 empty 2.05 67.8 18.4 No No
6 empty 2.05 60.1 21.8 No No
7 empty 2.2 64.3 17.8 No No
8 empty 2.29 65.2 19.1 No No
9 empty 1.5 30.3 19.8 No No
10 empty 1.92 63.2 19 No No
3NWD_B Envelope glycoprotein B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.21 42.5 74.1 Yes No
2 empty 1.91 59.1 29 No No
3 bound 2.01 63.3 27.5 No No
4 empty 2.11 66.7 17.2 No No
5 empty 1.88 74.2 19.2 No No
6 empty 2.18 60.8 26 No No
7 empty 2.13 64.6 15.7 No No
8 empty 1.98 64.1 21.8 No No
9 empty 2.43 52.4 20 No No
10 empty 2.13 56.5 27.4 No No
3NWF_C Envelope glycoprotein B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.96 47.6 81.2 Yes No
2 bound 2.08 67 26.9 No No
3 empty 2.15 61.5 24.1 No No
4 empty 1.96 65.1 20.8 No No
5 empty 1.97 72 17.5 No No
6 empty 2.07 59.2 23.9 No No
7 empty 1.97 60.6 20.8 No No
8 empty 2.12 47.8 15.8 No No
9 empty 1.78 58.7 13.7 No No
10 empty 1.9 61 13.5 No No
2GUM_A Envelope glycoprotein B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.23 46.3 92.2 Yes No
2 empty 2.42 69.5 25.9 No No
3 empty 2.66 63.8 28.5 No No
4 empty 2.03 68.8 25.1 No No
5 empty 1.97 67.3 25.1 No No
6 empty 2.05 66.9 19.4 No No
7 empty 2.02 66.5 21.4 No No
8 empty 2.12 78.7 18.3 No No
9 empty 2.44 59.8 19.8 No No
10 empty 1.49 29.4 18.5 No No
4HSI_C Envelope glycoprotein B Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.29 67.9 48.1 Yes Yes
2 empty 1.26 45.4 74.9 No No
3 empty 2.08 64.2 35.6 No No
4 empty 2.21 62.4 40.7 No No
5 empty 2.17 66.4 26.8 No No
6 empty 2.14 66.2 27.7 No No
7 empty 1.9 74.8 16.7 No No
8 empty 2.36 57.6 20.5 No No
9 empty 2.56 67.5 15.6 No No
10 empty 2.51 65.7 15.8 No No
4L1R_A Envelope glycoprotein B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.3 44.3 76.4 Yes No
2 bound 2.04 61.5 24.8 No No
3 empty 2.02 59.9 24.5 No No
4 empty 2.23 60.9 24.5 No No
5 empty 2.01 68.4 18.3 No No
6 empty 2.45 57.7 28.1 No No
7 empty 2.35 64.8 16.4 No No
8 empty 1.74 69.8 16.2 No No
9 empty 1.28 30.3 17.1 No No
10 empty 1.93 58.5 20.5 No No
4BOM_B Envelope glycoprotein B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.46 51 72.4 Yes No
2 empty 1.87 69 38.5 No No
3 empty 2.2 65.1 32.7 No No
4 empty 2.27 68.3 26.8 No No
5 empty 1.86 60.1 30.3 No No
6 empty 1.84 78.3 20 No No
7 empty 2.44 59 27.3 No No
8 empty 2.55 61.2 24.5 No No
9 empty 1.82 57.4 17.6 No No
10 empty 1.98 60 21.3 No No
3NWD_A Envelope glycoprotein B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.3 45.9 79.9 Yes No
2 empty 1.99 61.9 26.9 No No
3 bound 2.26 60.2 23.5 No No
4 empty 1.88 69 18.2 No No
5 empty 1.97 59.8 21.9 No No
6 empty 1.89 61.3 21.2 No No
7 empty 1.78 59.7 17.3 No No
8 empty 2.07 43.9 21.1 No No
9 empty 1.9 65.2 18.5 No No
10 empty 1.49 33.4 18 No No
3NWF_D Envelope glycoprotein B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.1 44.4 76.1 Yes No
2 empty 2.13 63.7 26.8 No No
3 bound 2.19 67.7 19.2 No No
4 empty 1.93 69.1 18.4 No No
5 empty 2.27 65.3 23.3 No No
6 bound 2.31 63 18.7 No No
7 empty 1.82 68.8 21 No No
8 empty 1.49 31.9 20 No No
9 empty 1.98 62.9 16.3 No No
10 empty 1.73 61.9 17 No No
2GUM_B Envelope glycoprotein B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.54 46.3 73.3 Yes No
2 empty 2.18 63.6 46.6 No No
3 empty 2.46 65.9 32.7 No No
4 empty 2 62.5 35.1 No No
5 empty 2.06 66.8 25.6 No No
6 empty 2.34 66.9 24 No No
7 empty 2.1 62.6 22.7 No No
8 empty 2.15 63.4 19.3 No No
9 empty 2.2 58.4 19 No No
10 empty 1.51 28.5 17.6 No No
3NWF_B Envelope glycoprotein B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.35 45.5 73.9 Yes No
2 empty 2.21 68.2 30.7 No No
3 bound 2.5 56.5 31.1 No No
4 empty 1.93 67 25.3 No No
5 empty 2.06 70.1 23.9 No No
6 empty 1.84 66.8 20.4 No No
7 empty 2.16 68.9 28.8 No No
8 empty 1.95 75.6 21.4 No No
9 empty 2.09 65.9 17.1 No No
10 empty 2.17 57 16.6 No No
3NWF_A Envelope glycoprotein B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.47 48.4 78.2 Yes No
2 empty 2.18 61.9 22.2 No No
3 bound 2.01 63.5 19.7 No No
4 empty 2.04 65.3 26.8 No No
5 empty 2.03 63.8 25 No No
6 empty 2.32 56.9 27 No No
7 empty 2.02 69.3 17.1 No No
8 empty 2.36 59.3 22.3 No No
9 empty 1.55 56.7 18.1 No No
10 empty 1.39 32.8 19.5 No No
4L1R_B Envelope glycoprotein B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.7 46.5 84.6 Yes No
2 bound 2.15 62.8 24.5 No No
3 empty 2.04 61.8 27.6 No No
4 empty 1.99 67.1 19.2 No No
5 empty 2.25 65.8 24.3 No No
6 empty 2.38 57.7 26.7 No No
7 empty 1.8 74.2 16.1 No No
8 empty 1.98 62.9 19.5 No No
9 empty 1.42 28.3 20 No No
10 empty 1.92 64.4 16.4 No No
3NWA_B Envelope glycoprotein B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.14 55.7 91.7 Yes No
2 empty 2.38 67.1 38.3 No No
3 empty 2.05 71.7 25.1 No No
4 empty 2.25 56.2 28 No No
5 empty 1.95 74 22.6 No No
6 empty 2.55 60.5 18.6 No No
7 empty 2.11 69.5 16.6 No No
8 empty 1.39 28.7 16.4 No No
9 empty 2.04 65.5 21.7 No No
10 empty 2.22 64.8 24.2 No No
3NWA_C Envelope glycoprotein B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.46 48 77.1 Yes No
2 bound 2.13 64.2 31.5 No No
3 empty 1.98 62.2 25.8 No No
4 empty 2.16 63.2 23.6 No No
5 empty 2.36 58.5 27.3 No No
6 empty 1.9 70.9 19.1 No No
7 empty 1.47 29.4 18.6 No No
8 empty 2.07 65.6 16.6 No No
9 empty 1.94 53 15.5 No No
10 empty 1.93 52.6 14.9 No No
5FZ2_B Envelope glycoprotein B Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.85 69.1 39.1 Yes Yes
2 empty 2.38 62.9 26.8 No No
3 empty 2.05 68.1 24 No No
4 empty 2.25 66.6 23.1 No No
5 empty 2 63.3 16.1 No No
6 empty 1.93 70 18.1 No No
7 empty 2.07 66.5 16 No No
8 empty 2.73 70.1 12.8 No No
9 empty 2.07 54.9 17 No No
10 empty 1.82 65.7 10 No No
4HSI_D Envelope glycoprotein B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.67 55.9 74.9 Yes No
2 empty 1.99 70.4 30.4 No No
3 empty 2.07 70.5 26.9 No No
4 empty 1.91 69.6 19.5 No No
5 empty 2 67.1 25.6 No No
6 empty 2.18 67.2 21.5 No No
7 empty 2.37 66.1 27.6 No No
8 empty 2.12 68 20.7 No No
9 empty 2.38 59.8 23.4 No No
10 empty 1.6 31.7 18.1 No No
3NW8_B Envelope glycoprotein B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.28 45.6 76.9 Yes No
2 bound 2.27 66 31.5 No No
3 empty 2.12 63.6 26.5 No No
4 empty 2.03 66.7 17.7 No No
5 empty 2.34 57 27.9 No No
6 empty 1.86 70.2 16.9 No No
7 empty 2.02 61.6 22.9 No No
8 empty 2.36 61.3 22.6 No No
9 empty 1.35 31.5 19.2 No No
10 empty 2.15 71.2 15.6 No No
5FZ2_C Envelope glycoprotein B Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.97 68.1 40.5 Yes Yes
2 empty 2.4 62.1 26.7 No No
3 empty 1.99 68.4 25.2 No No
4 empty 2.23 67 23.5 No No
5 empty 1.94 68.5 18.7 No No
6 empty 1.96 62.6 19.6 No No
7 empty 2.07 68.2 12.7 No No
8 empty 1.97 54.8 14.4 No No
9 empty 2.8 67.1 14.7 No No
10 empty 1.7 63.5 11.5 No No
4BOM_C Envelope glycoprotein B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.45 50.5 74.1 Yes No
2 empty 2.36 69.2 27.6 No No
3 empty 2.48 70.9 30.5 No No
4 empty 2.29 73.8 27.2 No No
5 empty 1.94 64.2 25 No No
6 empty 2.34 60.1 27.3 No No
7 empty 1.83 74.5 19.6 No No
8 empty 2.09 76 17.7 No No
9 empty 2.26 63.4 27 No No
10 empty 2.67 63.1 25.9 No No
3NW8_D Envelope glycoprotein B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.17 45.2 75.9 Yes No
2 bound 2.16 63.6 27.3 No No
3 empty 2.4 63.2 25.9 No No
4 empty 1.99 66.4 18.6 No No
5 empty 2.04 68.7 19.2 No No
6 empty 2.06 59.7 22.1 No No
7 empty 1.97 62.2 23.6 No No
8 empty 1.94 69.3 17.5 No No
9 empty 1.39 27.8 19.5 No No
10 empty 2.03 63.9 15.8 No No
3NWA_A Envelope glycoprotein B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.02 50.9 75.1 Yes No
2 empty 2.46 69.1 31.6 No No
3 empty 2.06 60.8 42 No No
4 empty 1.97 67.8 35.3 No No
5 empty 1.95 68.6 28.1 No No
6 empty 2.03 61.6 28.1 No No
7 empty 2.12 68.4 21.4 No No
8 empty 1.49 29.6 17.5 No No
9 empty 1.98 66.2 15.7 No No
10 empty 2.64 60.2 23.5 No No
3NWD_C Envelope glycoprotein B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.55 44.7 84.9 Yes No
2 bound 2.49 63.9 30.4 No No
3 empty 1.82 67.7 19 No No
4 empty 2 60.2 19.3 No No
5 empty 1.86 64.2 22.7 No No
6 empty 1.8 60.3 21 No No
7 empty 1.84 70.2 17.4 No No
8 empty 1.98 57.2 18.7 No No
9 empty 2.06 53.4 17.5 No No
10 empty 1.47 33.1 19.4 No No
3NWA_D Envelope glycoprotein B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.1 51.2 79.9 Yes No
2 empty 2.43 67.3 38.2 No No
3 empty 2.07 65 24.9 No No
4 empty 1.95 68.2 25 No No
5 empty 2.39 62.1 28.3 No No
6 empty 2.07 75.9 22.6 No No
7 empty 1.39 30.5 16.7 No No
8 empty 2.12 64.9 20 No No
9 empty 2.1 65.2 16.8 No No
10 empty 1.79 64.9 21.6 No No
4HSI_B Envelope glycoprotein B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.45 57.2 77.4 Yes No
2 empty 2.32 57.3 30.7 No No
3 empty 2.25 69.3 25.7 No No
4 empty 1.98 70.1 24 No No
5 empty 2.26 65.2 25.7 No No
6 empty 1.94 74.3 22.5 No No
7 bound 2.57 66.9 25.8 No No
8 empty 2.28 57.2 21 No No
9 empty 1.49 30.9 15.6 No No
10 empty 1.95 62.9 21.4 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed8
Domains assessed as druggable using the strict criteria1
Domains assessed as druggable using the relaxed criteria8

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
2GUM_A (147184) Envelope glycoprotein B Viral glycoprotein ectodomain-like, Viral glycoprotein ectodomain-like, Glycoprotein B-like 2.1Å Yes No
2GUM_B (147185) Envelope glycoprotein B Viral glycoprotein ectodomain-like, Viral glycoprotein ectodomain-like, Glycoprotein B-like 2.1Å Yes No
2GUM_C (147186) Envelope glycoprotein B Viral glycoprotein ectodomain-like, Viral glycoprotein ectodomain-like, Glycoprotein B-like 2.1Å Yes No
2GUM_A (4218804) Envelope glycoprotein B UNMATCHED, UNMATCHED, UNMATCHED 2GUM HOMO 2.1Å Yes Yes
2GUM_C (4218804) Envelope glycoprotein B UNMATCHED, UNMATCHED, UNMATCHED 2GUM HOMO 2.1Å Yes Yes
2GUM_B (4218804) Envelope glycoprotein B UNMATCHED, UNMATCHED, UNMATCHED 2GUM HOMO 2.1Å Yes Yes
3NW8_A (3640411) Envelope glycoprotein B Viral glycoprotein ectodomain-like, Viral glycoprotein ectodomain-like, UNMATCHED 2.759Å Yes No
3NWA_A (3640414) Envelope glycoprotein B Viral glycoprotein ectodomain-like, Viral glycoprotein ectodomain-like, UNMATCHED 2.26Å Yes No
3NWD_A (3640417) Envelope glycoprotein B Viral glycoprotein ectodomain-like, Viral glycoprotein ectodomain-like, UNMATCHED 2.88Å Yes No
3NWF_A (3640420) Envelope glycoprotein B Viral glycoprotein ectodomain-like, Viral glycoprotein ectodomain-like, UNMATCHED 2.8Å Yes No
Ligand-based Druggability Score:
Ligand-based Druggability Score Percentile: %
Ligand-based Druggability Help: Help




		
This protein has no network-based druggability score