Molecular Target Synopsis
Overview
Domains and Structures
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Druggability
Chemistry
Ligand Efficiency Plot
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Gene Copy Number Variation
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gB (P06437) - Overview - Molecular Target Synopsis

Protein


gB, Envelope glycoprotein B
UniProt P06437

Also Known as GB_HHV1K, gB

Envelope glycoprotein that forms spikes at the surface of virion envelope. Essential for the initial attachment to heparan sulfate moities of the host cell surface proteoglycans. Involved in fusion of viral and cellular membranes leading to virus entry into the host cell. Following initial binding to its host receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. May be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress. Also plays a role, together with gK, in virus-induced cell-to-cell fusion (syncytia formation). Homotrimer; disulfide-linked. Binds to heparan sulfate proteoglycans. Interacts with gH/gL heterodimer (By similarity). Interacts with the host coreceptor PILRA.

5XO2
7 RESIDUE FRAGMENT OF
PEPTIDE FROM ENVELOPE GLYCOPROTEIN B
IN THE STRUCTURE OF
CRYSTAL STRUCTURE OF HUMAN PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR ALPHA WITH SYNTHESIZED GLYCOPEPTIDE II
RCSB/PDB
Inspect Structure
See all 3D Structures for gB

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
904P06437-1

Sub-cellular localization


UniProt: gB is active in the following subcellular-locations: host golgi apparatus membrane, host cell membrane, host endosome membrane, virion membrane.
GO terms: gB is active in the following subcellular-locations: host cell endosome membrane, host cell Golgi membrane, host cell plasma membrane, integral component of membrane, viral envelope, virion membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project gB has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

RNA Interference


gB was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: . (see details)

3D Structures


For gB there are:
11 structures (35 chains) solved
8 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis