Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PGR (P06401) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 23/07/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 23/07/2019)


Chains assessed37
Chains with at least one site assessed as druggable using the strict criteria31
Chains with at least one site assessed as druggable using the relaxed criteria33


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
2OVM_A Progesterone receptor Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.61 71.8 29.2 Yes Yes
2 empty 1.9 83.7 20.9 Yes Yes
3 empty 1.86 77.8 21.2 No No
4 empty 2.5 68.5 14.8 No No
5 empty 2.21 64 21.9 No No
6 empty 2.2 66.3 14.3 No No
7 empty 2.64 64.1 18.9 No No
8 empty 2.12 67.8 11.3 No No
9 empty 1.87 69.2 15.1 No No
10 empty 2.22 63.9 12.3 No No
3ZR7_A Progesterone receptor Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.92 76.1 21.3 Yes Yes
2 empty 2.27 65.1 20.9 No No
3 bound 1.05 99.8 0 Yes No
4 bound 2.01 80.4 17.9 No No
5 empty 2.1 64.5 15 No No
6 empty 2.35 56.4 15.3 No No
7 bound 1.76 66.2 16.4 No No
8 bound 2.24 65.7 18.6 No No
9 empty 2.28 68 10.3 No No
10 empty 2.14 63.1 17.3 No No
3KBA_B Progesterone receptor Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.1 73.6 22.6 Yes Yes
2 empty 1.94 69.6 26 No No
3 bound 1.05 100 0 Yes No
4 empty 1.86 80.7 16.2 No No
5 empty 2.21 58.6 15.1 No No
6 empty 2.02 59.9 20.7 No No
7 empty 2.33 70.1 16.4 No No
8 empty 2.1 64.6 17.9 No No
9 empty 2.52 64.5 20.5 No No
10 empty 2.11 68 11.6 No No
1ZUC_B Progesterone receptor Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.05 74.4 27.9 Yes Yes
2 empty 2 78.8 17.9 Yes Yes
3 empty 2.13 55 16.5 No No
4 bound 1.13 99.7 0 Yes No
5 empty 2.2 64.1 18 No No
6 empty 2.12 60.1 13.6 No No
7 empty 2.32 74.6 11.5 No No
8 empty 1.41 70.5 13.5 No No
9 empty 2.85 63.9 18.9 No No
10 empty 2.13 59.8 14.9 No No
3G8O_A Progesterone receptor Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.94 66 32.2 Yes No
2 empty 2.04 79.1 17.4 Yes Yes
3 empty 2.34 74.1 29 No No
4 empty 2.01 80 16.5 No No
5 bound 1.11 99.8 0 Yes No
6 empty 2.1 64.5 14.7 No No
7 empty 2.58 72.5 12.3 No No
8 empty 2.18 66.7 15.1 No No
9 empty 2.38 62.2 14.7 No No
10 empty 2.46 67.6 10.8 No No
3KBA_A Progesterone receptor Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.95 83.4 17.1 Yes Yes
2 bound 1.08 99.5 0 Yes Yes
3 empty 2.05 65.5 16 No No
4 empty 1.77 80.7 16.1 No No
5 empty 1.9 65.4 16.8 No No
6 empty 2.46 67.6 12.4 No No
7 empty 1.81 70.5 14.5 No No
8 empty 1.68 70.6 17.7 No No
9 empty 2 66.8 15.3 No No
10 empty 1.94 60.3 16.5 No No
1E3K_A Progesterone receptor Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.89 81.6 20.6 Yes Yes
2 empty 2.17 65.9 31 No No
3 empty 2.02 78.1 18.6 No No
4 empty 2.55 64.1 19.3 No No
5 bound 1.05 99.7 0 Yes No
6 empty 2.07 67.7 19.9 No No
7 empty 2.35 69 14.6 No No
8 empty 2.45 57.8 13.1 No No
9 empty 2.08 60.2 19.1 No No
10 empty 1.98 65.9 14 No No
4OAR_A Progesterone receptor Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.33 73.9 26.4 Yes Yes
2 empty 1.89 83.7 18.9 Yes Yes
3 empty 2.15 71.7 20.3 No No
4 empty 2.12 60 17.5 No No
5 empty 1.95 61.5 17.3 No No
6 empty 2.11 63 17.5 No No
7 empty 2.49 71.7 11.6 No No
8 empty 1.85 59.3 13.2 No No
9 empty 1.87 65.6 11.3 No No
10 empty 1.63 96.2 0 Yes No
1A28_B Progesterone receptor Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.81 85.7 17.8 Yes Yes
2 empty 1.84 78.3 18.9 No No
3 bound 1.05 100 0 Yes No
4 empty 2.18 67.7 18.9 No No
5 empty 2.13 60.1 13.6 No No
6 empty 1.58 70 13.7 No No
7 empty 2.04 69.8 12.7 No No
8 empty 2.16 66 20.4 No No
9 empty 2.05 59.7 17.1 No No
10 empty 2.13 63.5 16.1 No No
3D90_A Progesterone receptor Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.9 75.8 19.5 Yes Yes
2 empty 1.98 65.7 24.6 No No
3 empty 2.45 62.4 23.9 No No
4 bound 1.09 100 0 Yes No
5 empty 2.04 73.8 15.1 No No
6 empty 1.66 80.8 16 No No
7 empty 2.52 69 14.1 No No
8 empty 2.11 65.9 17 No No
9 empty 2.4 62.5 13.9 No No
10 empty 2.05 63.9 12.4 No No
1A28_A Progesterone receptor Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.87 74.9 25.1 Yes No
2 empty 1.87 66.2 29.3 No No
3 empty 2.06 80.2 17.8 No No
4 bound 1.02 99.7 0 Yes No
5 empty 2.05 65.3 17.7 No No
6 empty 2.44 58.4 12.9 No No
7 empty 2.61 60.6 16.9 No No
8 empty 2.2 65.9 14.3 No No
9 empty 2.34 73.4 10.7 No No
10 empty 2.25 53.9 14.8 No No
1SQN_B Progesterone receptor Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.21 75.9 19.3 Yes Yes
2 empty 1.49 67 24.7 No No
3 empty 1.9 78.3 18.8 No No
4 bound 1.07 100 0 Yes No
5 empty 2.26 70.2 12 No No
6 empty 2.49 69.6 15.8 No No
7 empty 2.11 65.2 15.4 No No
8 empty 2.23 57.7 13.6 No No
9 empty 2.06 62.1 17.3 No No
10 empty 2.55 63.8 21.5 No No
3ZRB_B Progesterone receptor Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.12 76.8 24.1 Yes Yes
2 bound 1.06 100 0 Yes Yes
3 empty 1.91 82.1 18.7 No No
4 empty 2.26 56.5 16.5 No No
5 empty 2.46 69.8 13.2 No No
6 empty 2.22 71.5 13.2 No No
7 bound 2.09 66.4 13.7 No No
8 empty 2.38 60.4 19.2 No No
9 empty 1.8 67.2 16.9 No No
10 empty 2.11 60.6 12.8 No No
2W8Y_A Progesterone receptor Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.07 77.2 20.5 Yes Yes
2 empty 1.9 68.6 21.9 No No
3 bound 1.03 99.6 0 Yes No
4 empty 1.95 79.3 18.4 No No
5 empty 2.19 66.7 15.1 No No
6 empty 2.27 58.8 14.2 No No
7 empty 2.4 63.4 19.9 No No
8 empty 2.02 66.7 14.9 No No
9 empty 1.97 60.9 18.1 No No
10 empty 2.62 63.4 21.2 No No
3HQ5_A Progesterone receptor Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.93 83 16 Yes Yes
2 empty 2.64 62.4 30.6 No No
3 bound 1.74 78.8 18.4 No No
4 empty 2.33 68.9 18.6 No No
5 bound 1.08 99.5 0 Yes No
6 empty 1.42 71.9 15.1 No No
7 empty 2.12 65.8 20 No No
8 empty 2.14 68 18.5 No No
9 empty 2.52 71.9 13.3 No No
10 empty 1.96 61 17.3 No No
4A2J_A Progesterone receptor Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.2 74.6 21 Yes Yes
2 bound 1.08 99.4 0 Yes Yes
3 empty 2.06 79.5 18.9 No No
4 empty 2.3 65.3 18.5 No No
5 empty 2.1 56.2 16.2 No No
6 empty 2.26 66.3 12.4 No No
7 empty 2.12 62.7 12.3 No No
8 empty 2.01 66.6 19.1 No No
9 empty 1.58 71.4 12 No No
10 empty 1.96 59.3 17.9 No No
2OVH_A Progesterone receptor Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.67 74.2 25.1 Yes Yes
2 empty 1.9 79.7 20.3 Yes Yes
3 empty 2.03 81.3 21.2 No No
4 empty 2.4 66.5 19.7 No No
5 empty 2.54 64.2 18.5 No No
6 empty 2.12 61.9 18.7 No No
7 empty 1.9 69.1 11.2 No No
8 empty 2 65.9 17 No No
9 empty 2.12 64.7 11.8 No No
10 empty 2.66 62.4 14.4 No No
2C7A_B Progesterone receptor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.24 58.6 17.6 No No
2 empty 2.34 63.3 14.2 No No
3 empty 2.65 59.7 18.9 No No
4 empty 2.75 71.6 22.3 No No
5 empty 2.41 66.3 9.4 No No
6 empty 3.17 65.8 7.4 No No
7 empty 2.15 59.5 7.7 No No
8 empty 1.8 67 5.4 No No
9 empty 2.61 61.5 6.4 No No
10 empty 3.09 64.3 6 No No
4APU_A Progesterone receptor Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.1 64.6 25.8 Yes No
2 empty 1.9 84.4 17.5 Yes Yes
3 bound .99 99.7 0 Yes No
4 empty 1.85 78.5 18 No No
5 empty 2.54 68 15.2 No No
6 empty 2.02 67.4 21 No No
7 empty 2.32 58.7 15.9 No No
8 empty 2.43 62.4 17.9 No No
9 empty 2.1 65.9 15.9 No No
10 empty 2.14 63.7 17.5 No No
2W8Y_B Progesterone receptor Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.95 76.9 22.5 Yes Yes
2 empty 2.08 62.8 27.9 No No
3 empty 1.98 81.4 18.8 No No
4 bound 1.05 100 0 Yes No
5 empty 2.08 67.3 21.5 No No
6 empty 2.49 63.5 19.6 No No
7 empty 2.37 60.3 17.4 No No
8 empty 2.45 73.2 13.6 No No
9 empty 2.08 60.2 17.1 No No
10 empty 2.39 68 17.7 No No
1E3K_B Progesterone receptor Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.73 74.8 23.8 Yes Yes
2 empty 2.03 66.3 25.9 No No
3 empty 1.71 81.6 16.6 No No
4 empty 2.24 63.1 20.5 No No
5 bound 1.07 100 0 Yes No
6 empty 2.4 58.9 17.6 No No
7 empty 2.24 68.1 15.9 No No
8 empty 2.08 63.9 19.2 No No
9 empty 2.66 62 22.9 No No
10 empty 2.23 57.6 17 No No
3G8O_B Progesterone receptor Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.01 76.3 20.5 Yes Yes
2 bound 1.11 99.5 0 Yes Yes
3 empty 1.46 68.6 16.9 No No
4 empty 1.81 76.6 17.5 No No
5 empty 2.12 64.5 18 No No
6 empty 2.17 58 16.4 No No
7 empty 2.3 69.1 10.6 No No
8 empty 2.15 63.3 13.7 No No
9 empty 2.19 62.6 18.6 No No
10 empty 2.28 68.7 13.8 No No
1ZUC_A Progesterone receptor Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.98 74.6 27 Yes Yes
2 empty 2.14 66.5 31.7 No No
3 empty 2.13 68.8 18.5 No No
4 empty 1.83 81.3 16.3 No No
5 empty 2.37 65.6 16.8 No No
6 bound 1.12 100 0 Yes No
7 empty 2.54 62.4 18.9 No No
8 empty 2.26 67.9 13 No No
9 empty 2.32 50.1 15.6 No No
10 empty 1.81 58.8 15.7 No No
3ZRB_A Progesterone receptor Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.55 62.6 28.8 Yes No
2 empty 1.97 80.2 18 Yes Yes
3 bound 2.07 79.8 18.5 No No
4 bound 1.07 100 0 Yes No
5 empty 1.61 64.6 21.1 No No
6 empty 2 68.5 21.3 No No
7 empty 2.41 64.2 16 No No
8 empty 2.39 71.5 13.8 No No
9 empty 2.12 64.5 15.8 No No
10 empty 2.12 63.2 17.1 No No
3ZR7_B Progesterone receptor Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.86 64.8 29.6 Yes No
2 bound 1.9 82.5 18.4 Yes Yes
3 empty 2.39 65.3 24.9 No No
4 bound 2 79.7 18.7 No No
5 bound 1.05 100 0 Yes No
6 bound 2.11 70 19.8 No No
7 empty 2.38 59.2 15.5 No No
8 empty 2.32 69.9 13.6 No No
9 empty 2.11 66.2 16 No No
10 empty 1.94 60.4 16.2 No No
3HQ5_B Progesterone receptor Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.06 73.8 21.4 Yes Yes
2 bound 1.89 80.6 19.6 Yes Yes
3 bound .97 99.5 0 Yes No
4 empty 1.74 68.3 16.2 No No
5 empty 2.35 70.5 18.7 No No
6 empty 2.23 55.5 14.6 No No
7 empty 2.34 69.7 13 No No
8 empty 2.16 64.8 20.3 No No
9 empty 2.04 58.9 14.7 No No
10 empty 2.24 59.7 12.8 No No
4APU_B Progesterone receptor Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.01 76 22 Yes Yes
2 bound 1.06 99.7 0 Yes Yes
3 empty 2.26 63.4 19.7 No No
4 empty 2.11 64 17 No No
5 empty 1.83 77.3 17.1 No No
6 empty 1.51 70.5 16.7 No No
7 empty 2.11 58.9 14.7 No No
8 empty 2.36 72.7 11.3 No No
9 empty 2.1 62.4 19.5 No No
10 empty 2.58 66.9 20.4 No No
1SQN_A Progesterone receptor Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.92 76.6 19.5 Yes Yes
2 empty 2.3 73.5 28.3 No No
3 empty 1.83 78.7 17.1 No No
4 empty 1.66 68.2 18.1 No No
5 bound 1.08 100 0 Yes No
6 empty 2.45 68.7 13.6 No No
7 empty 2.3 58 15.8 No No
8 empty 2.15 65.2 19.3 No No
9 empty 1.95 62 17.2 No No
10 empty 1.73 61.8 18.1 No No
5CC0_A Progesterone receptor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.93 59.8 13.2 No No
2 empty 2.62 64.9 15.1 No No
3 empty 2.25 56.9 14.1 No No
4 empty 2.18 71.4 6.3 No No
5 empty 2.46 65.1 9 No No
6 empty 1.92 64.7 10.2 No No
7 empty 2.11 62.9 6.1 No No
8 empty 2.66 57.5 6.7 No No
9 empty 2.47 69.9 7.2 No No
10 empty 2.91 66.7 6.7 No No
3ZRA_B Progesterone receptor Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.16 75.2 24.4 Yes Yes
2 empty 1.98 63.8 29.6 No No
3 empty 2.09 78.4 19.7 No No
4 bound 1.11 99 0 Yes No
5 empty 2.06 69 20.9 No No
6 empty 2.05 63.4 19.9 No No
7 empty 2.47 72.2 12.8 No No
8 empty 2.1 62.4 17.8 No No
9 empty 2.39 62.7 15.7 No No
10 empty 2.49 64.8 16.5 No No
1SR7_A Progesterone receptor Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.1 68 30.1 Yes No
2 empty 2.64 64.2 31.2 No No
3 empty 2.04 81.7 18.4 No No
4 bound 1.08 99.6 0 Yes No
5 empty 1.92 80.1 18.2 No No
6 empty 2.47 68.5 13.5 No No
7 empty 2.11 66 14.5 No No
8 empty 1.85 67.7 14.3 No No
9 empty 2.09 58.8 17.6 No No
10 empty 2.58 62.3 17.4 No No
3ZRA_A Progesterone receptor Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.14 76.7 20.2 Yes Yes
2 empty 1.88 81.5 17.9 Yes Yes
3 bound 1.09 99.5 0 Yes No
4 empty 2.29 65.3 19.8 No No
5 empty 2.08 59.6 13.9 No No
6 empty 1.89 63.4 18.7 No No
7 empty 2.34 71.9 11.5 No No
8 empty 2.03 64.1 12.7 No No
9 empty 2.05 62.5 17.8 No No
10 empty 2.01 65.9 14.8 No No
4A2J_B Progesterone receptor Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.12 65 27.4 Yes No
2 empty 2.13 85.1 18.9 Yes Yes
3 bound 1.04 99.8 0 Yes No
4 empty 1.91 80.5 19.1 No No
5 empty 2.07 69.1 24.5 No No
6 empty 2.47 69.8 13.5 No No
7 empty 1.97 61.3 16.5 No No
8 empty 2.15 65.1 16.3 No No
9 empty 2.26 59.9 16.9 No No
10 empty 2.44 58.9 16.9 No No
1SR7_B Progesterone receptor Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.04 77.3 18.4 Yes Yes
2 bound 1.1 99.8 0 Yes Yes
3 bound 1.81 82.5 16.3 No No
4 empty 2.28 66 18.1 No No
5 empty 2.28 67.4 15.4 No No
6 empty 2.08 63.6 18.5 No No
7 empty 2.16 56.7 13.3 No No
8 empty 2.44 61.5 18.5 No No
9 empty 1.46 66.9 12.4 No No
10 empty 2.66 71.5 11.1 No No
3D90_B Progesterone receptor Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.82 82.7 18.7 Yes Yes
2 bound .97 99.8 0 Yes Yes
3 empty 1.76 79 17.9 No No
4 empty 2.09 65.5 18.8 No No
5 empty 2.4 69.4 13.6 No No
6 empty 1.7 70.9 11.2 No No
7 empty 2.03 64.4 13.6 No No
8 empty 2.14 59 13.6 No No
9 empty 2.24 68.9 17.2 No No
10 empty 1.91 62.8 14.6 No No
2C7A_A Progesterone receptor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.14 59 19.3 No No
2 empty 2.38 58.8 23.3 No No
3 empty 2.26 68.1 10.9 No No
4 empty 2.2 64.7 14 No No
5 empty 2.62 56.7 9.3 No No
6 empty 2.25 48.3 7.4 No No
7 empty 2.81 66.4 7.2 No No
8 empty 2.62 60 5.3 No No
9 empty 2.32 59.8 5.5 No No
10 empty 2.61 68.6 5 No No
5CC0_B Progesterone receptor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.01 67.9 12.2 No No
2 empty 2.6 62.9 17.9 No No
3 empty 2.37 62.9 8 No No
4 empty 1.26 56.5 6.8 No No
5 empty 2.75 61.7 6.8 No No
6 empty 2.35 67.4 6.3 No No
7 empty 2.27 60.4 6.4 No No
8 empty 1.84 60 6.5 No No
9 empty 2.76 66 5.7 No No
10 empty 2.96 50 6.7 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed27
Domains assessed as druggable using the strict criteria21
Domains assessed as druggable using the relaxed criteria26

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
1A28_A (19290) Progesterone receptor Nuclear receptor ligand-binding domain, Nuclear receptor ligand-binding domain, Nuclear receptor ligand-binding domain 1.8Å Yes No
1A28_B (19291) Progesterone receptor Nuclear receptor ligand-binding domain, Nuclear receptor ligand-binding domain, Nuclear receptor ligand-binding domain 1.8Å Yes Yes
1E3K_A (59193) Progesterone receptor Nuclear receptor ligand-binding domain, Nuclear receptor ligand-binding domain, Nuclear receptor ligand-binding domain 2.8Å Yes Yes
1E3K_B (59194) Progesterone receptor Nuclear receptor ligand-binding domain, Nuclear receptor ligand-binding domain, Nuclear receptor ligand-binding domain 2.8Å Yes Yes
1SQN_A (105944) Progesterone receptor Nuclear receptor ligand-binding domain, Nuclear receptor ligand-binding domain, Nuclear receptor ligand-binding domain 1.45Å Yes Yes
1SQN_B (105945) Progesterone receptor Nuclear receptor ligand-binding domain, Nuclear receptor ligand-binding domain, Nuclear receptor ligand-binding domain 1.45Å Yes Yes
1SR7_A (105957) Progesterone receptor Nuclear receptor ligand-binding domain, Nuclear receptor ligand-binding domain, Nuclear receptor ligand-binding domain 1.46Å Yes No
1SR7_B (105958) Progesterone receptor Nuclear receptor ligand-binding domain, Nuclear receptor ligand-binding domain, Nuclear receptor ligand-binding domain 1.46Å Yes Yes
1SR7_B (4071327) Progesterone receptor Nuclear receptor ligand-binding domain, Nuclear receptor ligand-binding domain, Nuclear receptor ligand-binding domain (Homo Multimer) 1.46Å Yes Yes
1SR7_A (4071327) Progesterone receptor Nuclear receptor ligand-binding domain, Nuclear receptor ligand-binding domain, Nuclear receptor ligand-binding domain (Homo Multimer) 1.46Å Yes Yes
1ZUC_A (125666) Progesterone receptor Nuclear receptor ligand-binding domain, Nuclear receptor ligand-binding domain, Nuclear receptor ligand-binding domain 2Å Yes Yes
1ZUC_B (125667) Progesterone receptor Nuclear receptor ligand-binding domain, Nuclear receptor ligand-binding domain, Nuclear receptor ligand-binding domain 2Å Yes Yes
1ZUC_B (4143448) Progesterone receptor Nuclear receptor ligand-binding domain, Nuclear receptor ligand-binding domain, Nuclear receptor ligand-binding domain (Homo Multimer) 2Å Yes No
1ZUC_A (4143448) Progesterone receptor Nuclear receptor ligand-binding domain, Nuclear receptor ligand-binding domain, Nuclear receptor ligand-binding domain (Homo Multimer) 2Å Yes No
2C7A_A (3050787) Progesterone receptor Glucocorticoid receptor-like (DNA-binding domain), Glucocorticoid receptor-like (DNA-binding domain), Nuclear receptor 2.5Å No No
2OVH_A (139380) Progesterone receptor Nuclear receptor ligand-binding domain, Nuclear receptor ligand-binding domain, Nuclear receptor ligand-binding domain 2Å Yes Yes
2OVM_A (139381) Progesterone receptor Nuclear receptor ligand-binding domain, Nuclear receptor ligand-binding domain, Nuclear receptor ligand-binding domain 2.6Å Yes Yes
2W8Y_A (3230830) Progesterone receptor Nuclear receptor ligand-binding domain, Nuclear receptor ligand-binding domain, UNMATCHED 1.8Å Yes Yes
3D90_A (3350847) Progesterone receptor Nuclear receptor ligand-binding domain, Nuclear receptor ligand-binding domain, UNMATCHED 2.26Å Yes Yes
3G8N_A (4208131) Progesterone receptor Nuclear receptor ligand-binding domain, Nuclear receptor ligand-binding domain, Nuclear receptor ligand-binding domain (Homo Multimer) 2.05Å Yes No
3G8N_A (3420970) Progesterone receptor Nuclear receptor ligand-binding domain, Nuclear receptor ligand-binding domain, UNMATCHED 2.05Å Yes Yes
3G8N_B (4208131) Progesterone receptor Nuclear receptor ligand-binding domain, Nuclear receptor ligand-binding domain, Nuclear receptor ligand-binding domain (Homo Multimer) 2.05Å Yes No
3G8O_A (3420971) Progesterone receptor Nuclear receptor ligand-binding domain, Nuclear receptor ligand-binding domain, UNMATCHED 1.9Å Yes Yes
3G8O_A (4079112) Progesterone receptor Nuclear receptor ligand-binding domain, Nuclear receptor ligand-binding domain, Nuclear receptor ligand-binding domain (Homo Multimer) 1.9Å Yes Yes
3G8O_B (4079112) Progesterone receptor Nuclear receptor ligand-binding domain, Nuclear receptor ligand-binding domain, Nuclear receptor ligand-binding domain (Homo Multimer) 1.9Å Yes Yes
3HQ5_B (4093241) Progesterone receptor Nuclear receptor ligand-binding domain, Nuclear receptor ligand-binding domain, Nuclear receptor ligand-binding domain (Homo Multimer) 2.05Å Yes No
3HQ5_A (3460460) Progesterone receptor Nuclear receptor ligand-binding domain, Nuclear receptor ligand-binding domain, UNMATCHED 2.05Å Yes Yes
3HQ5_A (4093241) Progesterone receptor Nuclear receptor ligand-binding domain, Nuclear receptor ligand-binding domain, Nuclear receptor ligand-binding domain (Homo Multimer) 2.05Å Yes No
3KBA_A (3500261) Progesterone receptor Nuclear receptor ligand-binding domain, Nuclear receptor ligand-binding domain, UNMATCHED 1.9Å Yes Yes
3ZR7_A (3720029) Progesterone receptor Nuclear receptor ligand-binding domain, Nuclear receptor ligand-binding domain, UNMATCHED 1.65Å Yes Yes
3ZRA_A (3720032) Progesterone receptor Nuclear receptor ligand-binding domain, Nuclear receptor ligand-binding domain, UNMATCHED 1.9Å Yes Yes
3ZRB_A (3720033) Progesterone receptor Nuclear receptor ligand-binding domain, Nuclear receptor ligand-binding domain, UNMATCHED 1.8Å Yes Yes
Ligand-based Druggability Score: 1.55
Ligand-based Druggability Score Percentile: 95%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


PGR is involved in 53 interactions in the network.


Druggability
Overall Druggability Percentile: 99.17
Druggability for Cancer Therapeutics: 99.57
Druggability for Other Therapeutics: 70.03
Cancer-Associated
Cancer-associated percentile : 99.42
Network Articulation Point
Is PGR critical for communication in the network?


Detailed Graph Legend:Help