Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

FABP3 (P05413) - Overview - Molecular Target Synopsis

Protein


FABP3, Fatty acid-binding protein, heart
UniProt P05413

Also Known as FABPH_HUMAN, FABP3, FABP11, MDGI

FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters.

6AQ1
THE CRYSTAL STRUCTURE OF HUMAN FABP3
RCSB/PDB
Inspect Structure
See all 3D Structures for FABP3

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: FABP3 is active in the following subcellular-locations: cytoplasm.
GO terms: FABP3 is active in the following subcellular-locations: cytosol, extracellular exosome, extracellular space, sarcoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project FABP3 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 1005 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: ACHN, MALME_3M, IGROV1

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HCC2885, JHH-1, NCI-N417

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HSMM, hMSC-AT

(see details)

3D Structures


For FABP3 there are:
20 structures (32 chains) solved
17 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


FABP3 has been screened with 95 compounds (117 bioactivities), 19 compounds have bioactivities that show binding affinity of <= 500nM (20 bioactivities). (see details)