Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNA Interference
Mutations

IL6 (P05231) - Overview - Molecular Target Synopsis

Protein


IL6, Interleukin-6
UniProt P05231

Also Known as IL6_HUMAN, IL6, IFNB2

Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation.

5FUC deposition date (25-JAN-16)
BIOPHYSICAL AND CELLULAR CHARACTERISATION OF A JUNCTIONAL EPITOPE ANTIBODY THAT LOCKS IL-6 AND GP80 TOGETHER IN A STABLE COMPLEX: IMPLICATIONS FOR NEW THERAPEUTIC STRATEGIES
RCSB/PDB
Inspect Structure
See all 3D Structures for IL6

Isoforms / Transcripts (Protein Coding)


Drugs


IL6 is targeted by Approved Drug Siltuximab. (see details)

Sub-cellular localization


UniProt: IL6 is active in the following subcellular-locations: secreted.
GO terms: IL6 is active in the following subcellular-locations: endoplasmic reticulum lumen, external side of plasma membrane, extracellular region, extracellular space, interleukin-6 receptor complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project IL6 has gain in 6 cell-lines, loss in 1 cell-lines and no signal in 998 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: NCI_H226, TK_10, RXF_393

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HCC366, JL-1, HCC1359

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, IMR-90, BJ

(see details)

RNA Interference


IL6 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: . (see details)

3D Structures


There are 11 structures (15 chains) solved for IL6
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


IL6 has been screened with 13 compounds (13 bioactivities), 11 compounds have bioactivities that show binding affinity of <= 500nM (11 bioactivities). (see details)