Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

APOD (P05090) - Overview - Molecular Target Synopsis

Protein


APOD, Apolipoprotein D
UniProt P05090

Also Known as APOD_HUMAN, APOD

APOD occurs in the macromolecular complex with lecithin-cholesterol acyltransferase. It is probably involved in the transport and binding of bilin. Appears to be able to transport a variety of ligands in a number of different contexts. Homodimer. In plasma, also exists as a disulfide-linked heterodimer with APOA2.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: APOD is active in the following subcellular-locations: secreted.
GO terms: APOD is active in the following subcellular-locations: cytoplasm, cytosolic ribosome, dendrite, endoplasmic reticulum, extracellular exosome, extracellular region, extracellular space, neuronal cell body, perinuclear region of cytoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project APOD has gain in 6 cell-lines, loss in 3 cell-lines and no signal in 992 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MALME_3M, SK_MEL_2, SK_MEL_28

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: CAL-148, ZR-75-1, SK-MEL-2

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For APOD there are:
2 structures (2 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis