Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
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Gene Copy Number Variation
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alkB (P05050) - Overview - Molecular Target Synopsis

Protein


alkB, Alpha-ketoglutarate-dependent dioxygenase AlkB
Enzyme Classification 1.14.11.33
UniProt P05050

Also Known as ALKB_ECOLI, alkB, aidD

Dioxygenase that repairs alkylated DNA and RNA containing 3-methylcytosine or 1-methyladenine by oxidative demethylation. Has highest activity towards 3-methylcytosine. Has lower activity towards alkylated DNA containing ethenoadenine, and no detectable activity towards 1-methylguanine or 3-methylthymine. Accepts double-stranded and single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron. Provides extensive resistance to alkylating agents such as MMS and DMS (SN2 agents), but not to MMNG and MNU (SN1 agents).

4RFR
COMPLEX STRUCTURE OF ALKB/RHEIN
RCSB/PDB
Inspect Structure
See all 3D Structures for alkB

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
216P05050-1

Gene Copy Number Variation


In COSMIC - Cell Lines Project alkB has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For alkB there are:
34 structures (37 chains) solved
28 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis