Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

pepN (P04825) - Overview - Molecular Target Synopsis

Protein


pepN, Aminopeptidase N
Enzyme Classification 3.4.11.2
UniProt P04825

Also Known as AMPN_ECOLI, pepN

Aminopeptidase N is involved in the degradation of intracellular peptides generated by protein breakdown during normal growth as well as in response to nutrient starvation.

5YQB
CRYSTAL STRUCTURE OF E.COLI AMINOPEPTIDASE N IN COMPLEX WITH PUROMYCIN
RCSB/PDB
Inspect Structure
See all 3D Structures for pepN

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
870P04825-1

Sub-cellular localization


UniProt: pepN is active in the following subcellular-locations: cell inner membrane.
GO terms: pepN is active in the following subcellular-locations: cytoplasm, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project pepN has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For pepN there are:
42 structures (42 chains) solved
35 are solved in complex with at least one small molecule ligand
4 are solved with an approved drug

pepN is solved in complex with the approved drug(s):

TYR/TYROSINE (3B37_A),
MET/METHIONINE (4XN4_A, 4XO4_A),
TRP/TRYPTOPHAN (3B3B_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


pepN has been screened with 5 compounds (5 bioactivities). (see details)