Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

Ldha (P04642) - Overview - Molecular Target Synopsis

Protein


Ldha, L-lactate dehydrogenase A chain
Enzyme Classification 1.1.1.27
UniProt P04642

Also Known as LDHA_RAT, Ldha, Ldh-1, Ldh1

Homotetramer.

5ES3
CO-CRYSTAL STRUCTURE OF LDH LIGANDED WITH OXAMATE
RCSB/PDB
Inspect Structure
See all 3D Structures for Ldha

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
332P04642-1

Sub-cellular localization


UniProt: Ldha is active in the following subcellular-locations: cytoplasm.
GO terms: Ldha is active in the following subcellular-locations: cytoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project Ldha has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For Ldha there are:
13 structures (56 chains) solved
12 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


Ldha has been screened with 26 compounds (60 bioactivities), 7 compounds have bioactivities that show binding affinity of <= 500nM (10 bioactivities). (see details)