Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ASL (P04424) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 23/07/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 23/07/2019)


Chains assessed4
Chains with at least one site assessed as druggable using the strict criteria1
Chains with at least one site assessed as druggable using the relaxed criteria4


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
1AOS_B Argininosuccinate lyase Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.06 66.9 30.5 Yes No
2 empty 2.13 64.6 25.1 No No
3 empty 1.98 61.1 26.7 No No
4 empty 2.45 65.2 24.6 No No
5 empty 2.15 67 17.8 No No
6 empty 2.15 66.4 23.5 No No
7 empty 1.95 69.2 17.2 No No
8 empty 2.15 59.4 23.5 No No
9 empty 2.21 62.2 20.5 No No
10 empty 1.85 64.7 17.3 No No
1K62_A Argininosuccinate lyase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.04 67.9 39.1 Yes Yes
2 empty 1.98 61.8 34.2 No No
3 empty 2.41 66.8 24.8 No No
4 empty 2.36 60 30.2 No No
5 empty 2.42 64.7 24.3 No No
6 empty 2.06 69.2 14.4 No No
7 empty 2.46 64.9 17 No No
8 empty 2.14 66.4 12.7 No No
9 empty 2.04 83.5 12 No No
10 empty 1.68 56.9 13.7 No No
1AOS_A Argininosuccinate lyase Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.05 64.7 31.1 Yes No
2 empty 1.88 62.4 26.6 No No
3 empty 2.21 65.8 26.5 No No
4 empty 2.54 67.2 26.1 No No
5 empty 2.15 64.9 17.6 No No
6 empty 2.11 66.2 20.8 No No
7 empty 2.29 64.2 21.9 No No
8 empty 2.24 62.4 24.4 No No
9 empty 2.18 60 22.7 No No
10 empty 2.1 67 16.6 No No
1K62_B Argininosuccinate lyase Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.05 65.5 61.7 Yes No
2 empty 2.3 59.9 28.5 No No
3 empty 2.35 66 24.5 No No
4 empty 2.3 59.7 22.1 No No
5 empty 2.12 83 12.8 No No
6 empty 2.19 67.5 16.5 No No
7 empty 1.79 62.4 15.4 No No
8 empty 2.2 63.1 17.1 No No
9 empty 2.04 76.1 13.9 No No
10 empty 2.44 65.6 17.3 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed6
Domains assessed as druggable using the strict criteria3
Domains assessed as druggable using the relaxed criteria6

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
1AOS_A (19414) Argininosuccinate lyase L-aspartase-like, L-aspartase-like, L-aspartase/fumarase 4Å Yes No
1AOS_A (4195342) Argininosuccinate lyase L-aspartase-like, L-aspartase-like, L-aspartase/fumarase (Homo Multimer) 4Å Yes Yes
1AOS_B (4195342) Argininosuccinate lyase L-aspartase-like, L-aspartase-like, L-aspartase/fumarase (Homo Multimer) 4Å Yes Yes
1AOS_B (19415) Argininosuccinate lyase L-aspartase-like, L-aspartase-like, L-aspartase/fumarase 4Å Yes No
1K62_B (4220715) Argininosuccinate lyase L-aspartase-like, L-aspartase-like, L-aspartase/fumarase (Homo Multimer) 2.65Å Yes Yes
1K62_A (4220715) Argininosuccinate lyase L-aspartase-like, L-aspartase-like, L-aspartase/fumarase (Homo Multimer) 2.65Å Yes Yes
1K62_A (68213) Argininosuccinate lyase L-aspartase-like, L-aspartase-like, L-aspartase/fumarase 2.65Å Yes Yes
1K62_B (68214) Argininosuccinate lyase L-aspartase-like, L-aspartase-like, L-aspartase/fumarase 2.65Å Yes No
Ligand-based Druggability Score: -3
Ligand-based Druggability Score Percentile: 59%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


ASL is involved in 6 interactions in the network.


Druggability
Overall Druggability Percentile: 52.97
Druggability for Cancer Therapeutics: 62.98
Druggability for Other Therapeutics: 36.70
Cancer-Associated
Cancer-associated percentile : 50.36
Network Articulation Point
Is ASL critical for communication in the network?


Detailed Graph Legend:Help