Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ASL (P04424) - Overview - Molecular Target Synopsis

Protein


ASL, Argininosuccinate lyase
Enzyme Classification 4.3.2.1
UniProt P04424

Also Known as ARLY_HUMAN, ASL

Homotetramer.

1K62
CRYSTAL STRUCTURE OF THE HUMAN ARGININOSUCCINATE LYASE Q286R MUTANT
RCSB/PDB
Inspect Structure
See all 3D Structures for ASL

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


GO terms: ASL is active in the following subcellular-locations: cytoplasm, cytosol, extracellular exosome.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ASL has gain in 4 cell-lines, loss in 2 cell-lines and no signal in 999 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: NCI_H322M, HT29, COLO205

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, GTL-16, MKN-45

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HMEC, SK-N-SH_RA

(see details)

3D Structures


For ASL there are:
2 structures (4 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis