Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ATP2A1 (P04191) - Overview - Molecular Target Synopsis

Protein


ATP2A1, Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
Enzyme Classification 7.2.2.10
UniProt P04191

Also Known as AT2A1_RABIT, ATP2A1

Key regulator of striated muscle performance by acting as the major Ca(2+) ATPase responsible for the reuptake of cytosolic Ca(2+) into the sarcoplasmic reticulum. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction. Interacts with sarcolipin (SLN) (By similarity). Interacts with phospholamban (PLN) (PubMed:10551848, PubMed:8428955). Interacts with myoregulin (MRLN) (By similarity). Interacts with DWORF.

5ZMW
CRYSTAL STRUCTURE OF THE E309Q MUTANT OF SR CA2+-ATPASE IN E2(TG)
RCSB/PDB
Inspect Structure
See all 3D Structures for ATP2A1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
1001P04191-1
994P04191-2

Sub-cellular localization


UniProt: ATP2A1 is active in the following subcellular-locations: endoplasmic reticulum membrane, sarcoplasmic reticulum membrane.
GO terms: ATP2A1 is active in the following subcellular-locations: endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum-Golgi intermediate compartment, H zone, I band, integral component of membrane, membrane, perinuclear region of cytoplasm, sarcoplasmic reticulum, sarcoplasmic reticulum membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ATP2A1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For ATP2A1 there are:
71 structures (92 chains) solved
63 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ATP2A1 has been screened with 75 compounds (82 bioactivities), 27 compounds have bioactivities that show binding affinity of <= 500nM (32 bioactivities). (see details)