ATP2A1, Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
Enzyme Classification 220.127.116.11
Also Known as
Key regulator of striated muscle performance by acting as the major Ca(2+) ATPase responsible for the reuptake of cytosolic Ca(2+) into the sarcoplasmic reticulum. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction. Interacts with sarcolipin (SLN) (By similarity). Interacts with phospholamban (PLN) (PubMed:10551848, PubMed:8428955). Interacts with myoregulin (MRLN) (By similarity). Interacts with DWORF.