Molecular Target Synopsis
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RPO21 (P04050) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 10/09/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 10/09/2019)


Chains assessed132
Chains with at least one site assessed as druggable using the strict criteria123
Chains with at least one site assessed as druggable using the relaxed criteria131


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
1Y77_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.52 67.5 106.8 Yes Yes
2 empty .91 66.7 54.7 No No
3 empty 2.05 69.7 35.4 No No
4 empty 2.13 67 32.8 No No
5 empty 1.89 65.4 28.2 No No
6 empty 2.17 67.5 23.3 No No
7 empty 2.02 64.4 20.7 No No
8 empty 2.12 69.6 20.8 No No
9 empty 2.3 61.5 24.3 No No
10 empty 2.23 63.6 18.9 No No
4V1M_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.43 68.5 92 Yes Yes
2 empty 1 68.1 46.5 No No
3 empty 1.66 69.9 35 No No
4 empty 1.85 63.2 42.6 No No
5 empty 2.13 68 36.2 No No
6 empty 2.4 56.1 37 No No
7 empty 2.16 67.4 36 No No
8 empty 1.93 66.1 30.8 No No
9 empty 2.05 59.3 33.4 No No
10 empty 2.07 51.1 19 No No
5C4J_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.85 69.3 106.2 Yes Yes
2 empty 1.68 68.6 55.9 No No
3 empty 1.29 66.4 45 No No
4 empty 2.3 70.6 27.8 No No
5 empty 1.88 72.6 23.4 No No
6 empty 2.09 69 31.1 No No
7 empty 2.03 65.4 26.4 No No
8 empty 2.17 58.1 28.2 No No
9 empty 2.11 64.1 27.6 No No
10 empty 2.1 75.7 14.4 No No
5OQJ_A DNA-directed RNA polymerase II subunit RPB1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.62 63.5 78.8 Yes No
2 empty 1.43 69.1 74.5 No No
3 empty 2.17 67.9 43.6 No No
4 empty 2.09 72.3 46.9 No No
5 empty 2.13 52.2 35.5 No No
6 empty 2.07 64.6 35.2 No No
7 empty 1.02 69.4 37.5 No No
8 empty 1.91 68.4 25.3 No No
9 empty 2.25 68.3 32.1 No No
10 empty 2.09 62.7 35.1 No No
3GTM_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.38 67.8 100.3 Yes Yes
2 empty .91 66.4 52 No No
3 empty 1.89 63.5 40.1 No No
4 empty 2.17 69.1 34.9 No No
5 empty 2.43 66.3 28.6 No No
6 empty 2.17 65.8 23.2 No No
7 empty 2.09 69.8 27.6 No No
8 empty 2.32 66.5 34.8 No No
9 empty 2.54 67.4 23.6 No No
10 empty 2.17 66.8 20.5 No No
4A3I_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.41 68.1 91.1 Yes Yes
2 empty .96 66.4 45.4 No No
3 empty 1.8 62.1 42.6 No No
4 empty 1.74 67.9 35.8 No No
5 empty 2.07 69.6 33.5 No No
6 empty 1.93 67.5 32.4 No No
7 empty 2.39 54.4 31.7 No No
8 empty 2.36 63.3 27.3 No No
9 empty 1.96 49 22.9 No No
10 empty 2.35 68.2 26.1 No No
2NVQ_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.54 68.7 103.1 Yes Yes
2 empty 2.33 64.6 37.1 No No
3 empty 1.01 72.3 36.8 No No
4 empty 2.14 49.5 36.5 No No
5 empty 1.89 65.2 32.6 No No
6 empty 2.1 69.6 27.5 No No
7 empty 2.12 69.9 34.2 No No
8 empty 2.19 69.1 24 No No
9 empty 2.19 64.5 36.4 No No
10 empty 2.25 50.5 20.9 No No
3K1F_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.44 67.6 109.4 Yes Yes
2 empty 2.18 55.9 39.2 No No
3 empty 2.08 65.9 45.1 No No
4 empty 1.91 62.4 40 No No
5 empty 2.21 65.5 18.7 No No
6 empty 2.18 64 29.1 No No
7 empty 2.13 62.7 26.6 No No
8 empty 2.15 67.2 19.4 No No
9 empty 2.26 67.9 18.7 No No
10 empty 2.35 69.5 14.4 No No
1I50_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.91 68.6 80 Yes Yes
2 empty 1.68 67.6 70.1 No No
3 empty 2.39 73 46.5 No No
4 empty 2.27 67.7 34.9 No No
5 empty 1.01 67.7 46.2 No No
6 empty 1.89 71.5 33.4 No No
7 empty 1.94 59.7 42.6 No No
8 empty 2.11 68 35.5 No No
9 empty 2.31 61.4 31.3 No No
10 empty 2.39 68 25.1 No No
5OQM_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.45 68.5 81.7 Yes Yes
2 empty 1.58 64.6 79.7 No No
3 empty 1.02 68.5 47.8 No No
4 empty 2.07 72 36.9 No No
5 empty 2.08 51.5 32.3 No No
6 empty 2 68.4 26.8 No No
7 empty 2.1 67.7 31.7 No No
8 empty 2.06 64.5 32.3 No No
9 empty 2.13 67.8 22 No No
10 empty 2.39 60.9 29.4 No No
4A3B_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.41 68.4 91.9 Yes Yes
2 empty .98 67.3 46.5 No No
3 empty 1.77 69.5 44.2 No No
4 empty 2.2 53.6 35.5 No No
5 empty 2.22 67.8 28.1 No No
6 empty 2.53 66.1 28.5 No No
7 empty 2.22 70.1 26.1 No No
8 empty 2.26 63.4 27.2 No No
9 empty 1.94 49.8 19.5 No No
10 empty 2.28 63.8 27.2 No No
6BM4_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.52 67.9 93.2 Yes Yes
2 empty .96 68.6 46 No No
3 empty 1.97 69.1 32.8 No No
4 empty 2.17 55.1 42.2 No No
5 empty 1.86 62.9 40.3 No No
6 empty 2.12 69.2 33.4 No No
7 empty 2.12 51.4 21.3 No No
8 empty 2.25 68.4 26.4 No No
9 empty 1.93 65.2 27.1 No No
10 empty 2.27 66.1 25.1 No No
3H3V_B DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.49 67.7 104.6 Yes Yes
2 empty 2.11 67.4 84.8 No No
3 empty 1.99 69.5 38.7 No No
4 empty 2.06 68.1 50.8 No No
5 empty 2.07 64.1 35.4 No No
6 empty 2.46 66.5 27.6 No No
7 empty 2.48 66.8 22 No No
8 empty 2.18 60.9 21.8 No No
9 empty 2.17 66.1 25.7 No No
10 empty 1.9 61.2 20.9 No No
4BXZ_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.4 66.9 106.8 Yes Yes
2 empty 2.26 64.5 45.6 No No
3 empty 2 62.9 27.6 No No
4 empty 2.2 65 26.3 No No
5 empty 2.22 61.9 31.2 No No
6 empty 2.39 64.6 26.9 No No
7 empty 2.33 61 20.8 No No
8 empty 1.95 64.6 19.3 No No
9 empty 2.04 64.8 26.5 No No
10 empty 2.4 59.1 22.8 No No
4BXX_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.37 66.8 106.4 Yes Yes
2 empty 1.73 68.9 44 No No
3 empty 2.12 65.5 38.7 No No
4 empty 2.12 62.9 32.9 No No
5 empty 1.85 70.4 18.5 No No
6 empty 2.46 69.5 26.1 No No
7 empty 2.23 63.4 23.2 No No
8 empty 1.69 64.8 22 No No
9 empty 1.98 64.4 19.9 No No
10 empty 2.02 90 18.8 Yes No
3S2H_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.47 69.1 91.1 Yes Yes
2 empty 2.39 70 38.2 No No
3 empty 1.98 69.4 32 No No
4 empty 2.05 75.9 39.4 No No
5 empty 1.03 68.4 35.8 No No
6 empty 2.36 51.9 33.9 No No
7 empty 2.54 65.7 31 No No
8 empty 2.21 68 35.2 No No
9 empty 2.14 64.8 31.4 No No
10 empty 2.34 53.7 20.4 No No
4BBR_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.31 68.6 94.3 Yes Yes
2 empty 2.2 71.5 58.6 No No
3 empty 1.02 70.8 39.1 No No
4 empty 2.02 58.9 39.7 No No
5 empty 2.46 65.3 28.8 No No
6 empty 2.03 64.7 27 No No
7 empty 2.18 69.1 32.8 No No
8 empty 1.88 58.2 29.9 No No
9 empty 2.39 54.7 26.3 No No
10 empty 2.27 62.5 27.8 No No
5FMF_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.33 68.2 89.3 Yes Yes
2 empty .98 66.4 51.5 No No
3 empty 1.88 66.7 54.2 No No
4 empty 2.39 54.9 32 No No
5 empty 2.09 67.9 39.4 No No
6 empty 2.42 62.5 26.9 No No
7 empty 2.07 52.3 20 No No
8 empty 2.06 57.3 24.6 No No
9 empty 2.18 63.6 19.6 No No
10 empty 1.93 68.9 21 No No
4V1O_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.31 68.4 89.7 Yes Yes
2 empty 1.04 66.4 54.1 No No
3 empty 1.86 70 36.6 No No
4 empty 2.45 53.9 36 No No
5 empty 2.1 65.7 27.8 No No
6 empty 2.15 68.7 33.9 No No
7 empty 2.02 58.6 33.7 No No
8 empty 2.37 63.4 27.1 No No
9 empty 2.06 52.3 20 No No
10 empty 2.2 63.8 19.6 No No
2B8K_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.48 67.7 105 Yes Yes
2 empty .94 65.8 54.1 No No
3 empty 2.15 72.6 28.1 No No
4 empty 2.16 65.3 34 No No
5 empty 2.22 67.4 20.9 No No
6 empty 1.82 66.8 21.2 No No
7 empty 2.15 69.8 17.3 No No
8 empty 2.43 66.1 22.2 No No
9 empty 2.38 72.6 14.6 No No
10 empty 1.93 70.3 16.3 No No
5IP9_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.29 69 92 Yes Yes
2 empty .98 66.2 46.1 No No
3 empty 1.95 70.8 37.4 No No
4 empty 1.89 63.3 40.3 No No
5 empty 2.54 69.1 28.3 No No
6 empty 2.32 52.3 31.9 No No
7 empty 2.28 68.4 32.4 No No
8 empty 2.07 63.3 34.5 No No
9 empty 1.99 54.3 19.4 No No
10 empty 1.86 66.1 19.7 No No
2YU9_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.52 67 63 Yes Yes
2 bound 2.04 69.6 63.5 No No
3 empty 1.97 65.4 33.7 No No
4 empty 1.98 57.8 39.1 No No
5 empty 2.02 69.5 28.5 No No
6 empty 2.42 61.6 38.9 No No
7 empty 1.75 59.4 29.6 No No
8 empty .83 66 41.5 No No
9 empty 2.17 49.5 33.3 No No
10 empty 2.28 64.3 21.5 No No
5C3E_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.01 68.4 101.4 Yes Yes
2 empty .93 68.3 48 No No
3 empty 2.14 71 40.3 No No
4 empty 1.93 66.6 31.2 No No
5 empty 2.09 57.6 36 No No
6 empty 1.93 63.7 49.1 No No
7 empty 2.18 63.3 25.7 No No
8 empty 2.1 66.1 25.5 No No
9 empty 2.3 59.4 25.8 No No
10 empty 1.93 63.9 19.1 No No
3J0K_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.46 68.5 106.4 Yes Yes
2 empty .94 68.1 46.9 No No
3 empty 1.93 64.5 38.3 No No
4 empty 2.16 70 32.7 No No
5 empty 2.09 67.9 33.4 No No
6 empty 2.28 63.1 20.3 No No
7 empty 1.89 62 30.1 No No
8 empty 2.38 67.6 25.1 No No
9 empty 2.14 63.2 25.7 No No
10 empty 2.39 63.6 25.9 No No
5C44_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.89 69.4 101.4 Yes Yes
2 empty 2 66.2 31.4 No No
3 empty 2.39 58.3 39.9 No No
4 empty .99 69.4 43.6 No No
5 empty 2.27 69.3 28.8 No No
6 empty 2.09 65.7 40.6 No No
7 empty 1.96 64.4 27.5 No No
8 empty 2.09 59.4 28.3 No No
9 empty 2.17 68.7 25.5 No No
10 empty 2 57.6 22.8 No No
4A3K_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.38 67.7 93.5 Yes Yes
2 empty 1.05 66.9 46.2 No No
3 empty 1.66 67.6 37.7 No No
4 empty 2.3 53.6 31.8 No No
5 empty 2.2 69.8 35.1 No No
6 empty 1.88 67.6 29 No No
7 empty 2.04 69 33.2 No No
8 empty 2.26 63.3 27.2 No No
9 empty 2.05 64.1 35.7 No No
10 empty 1.96 51.3 19.4 No No
5SVA_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.48 68.7 89 Yes Yes
2 empty 1.82 69.4 35.8 No No
3 empty 1.89 64.9 40.1 No No
4 empty 1.87 63.5 41.8 No No
5 empty 1.08 71.7 39 No No
6 empty 2.05 66.2 29.3 No No
7 empty 2.48 55.2 32.1 No No
8 empty 2.03 69.4 30.9 No No
9 empty 2.43 63.1 27.9 No No
10 empty 2.13 52.1 19.1 No No
1Y1V_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.52 68.4 99.6 Yes Yes
2 empty 1.11 67.6 61 No No
3 empty 1.88 65.3 37.8 No No
4 empty 2.11 68.3 45.4 No No
5 empty 2.22 66.4 33 No No
6 empty 2.15 68 23 No No
7 empty 2.3 68.6 28.7 No No
8 empty 2.16 59.4 25 No No
9 empty 1.77 66.3 18.9 No No
10 empty 2.3 64.8 25 No No
4A3G_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.4 68.2 91.5 Yes Yes
2 empty 1.69 69.3 41.2 No No
3 empty 1.98 60 43.9 No No
4 empty 2.28 55.2 31.3 No No
5 empty 2.15 69.2 33.6 No No
6 empty 1.87 67.2 30.5 No No
7 empty 2.41 67.2 25.3 No No
8 empty 2.28 63.8 27.4 No No
9 empty 2.14 51 19.8 No No
10 empty 2.15 60.2 32.9 No No
4A3M_A DNA-directed RNA polymerase II subunit RPB1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.49 66 88.6 Yes No
2 empty 1.87 68.4 31.1 No No
3 empty .92 65.4 41.6 No No
4 empty 2.21 63.7 29.3 No No
5 empty 2.28 59.9 24 No No
6 empty 1.46 74.1 15.8 No No
7 empty 2.12 43 24.8 No No
8 empty 2.12 67.6 22.2 No No
9 empty 2.15 60.2 18.2 No No
10 empty 2.15 64.4 18.2 No No
3HOV_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.53 67.1 103.5 Yes Yes
2 empty 1.17 69.6 45.8 No No
3 empty 2.14 66.6 41.2 No No
4 empty 1.93 72.2 34.1 No No
5 empty 2.03 66.9 50 No No
6 empty 1.93 71.5 32.7 No No
7 empty 2.1 66.6 21 No No
8 empty 2.34 66.2 26.3 No No
9 empty 2.43 59 35.5 No No
10 empty 2.17 66.2 22.1 No No
6BLP_A DNA-directed RNA polymerase II subunit RPB1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.1 63 78.5 Yes No
2 empty 1.48 69.1 70.9 No No
3 empty 1.94 63.7 37 No No
4 empty 1.94 68.4 30.6 No No
5 bound 1.84 66.4 33.1 No No
6 empty 1.06 66.6 34.3 No No
7 empty 2.12 58.7 30.6 No No
8 empty 1.92 74.9 23.8 No No
9 empty 2.18 56.6 29.2 No No
10 empty 2.06 63.4 32.2 No No
1R9T_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.65 68.6 91.5 Yes Yes
2 empty 2.18 68.8 53.1 No No
3 empty .95 67.5 51.5 No No
4 empty 1.97 58.8 42.1 No No
5 empty 2.17 52 20.3 No No
6 empty 2.35 44.6 23.1 No No
7 empty 2.27 66.5 20.3 No No
8 empty 2.44 68.2 33.1 No No
9 empty 2.18 62.6 24.5 No No
10 empty 1.93 65.5 25.3 No No
1TWG_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.06 68.8 96.2 Yes Yes
2 empty 2.4 63.4 45.8 No No
3 empty 1.97 59 40.9 No No
4 empty 2.12 60.9 36.4 No No
5 empty 2.12 67.3 46 No No
6 empty 2.14 66.4 51.8 No No
7 empty 2.04 65.1 33.3 No No
8 empty 1.06 72.2 32.5 No No
9 empty 2.3 55.3 28.2 No No
10 empty 1.98 60.9 24.1 No No
3J1N_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.29 71.8 113.3 Yes Yes
2 empty 1.24 64.3 48.8 No No
3 empty 1.76 77.9 22.4 No No
4 empty 1.47 55.3 18.4 No No
5 empty 1.6 61.8 17.3 No No
6 empty 1.22 69 14.4 No No
7 empty 1.73 74 9.5 No No
8 empty 2.07 76.4 9.7 No No
9 empty 1.66 70.6 12.5 No No
10 empty 1.21 96.7 0 Yes No
3S1Q_A DNA-directed RNA polymerase II subunit RPB1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.55 66 65.8 Yes No
2 bound 1.51 68.2 63.8 No No
3 bound 1.91 66.2 64.5 No No
4 empty 2.37 66.5 33.3 No No
5 empty 2.29 58.2 36.1 No No
6 empty .91 64.5 37.2 No No
7 empty 2.21 49.5 32 No No
8 empty 2.14 61.5 28.3 No No
9 empty 1.9 65.7 31 No No
10 empty 2.03 60.6 38.6 No No
3FKI_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.96 68.8 106.7 Yes Yes
2 empty 1.96 66.9 53.5 No No
3 empty 1.03 69.4 48.7 No No
4 empty 2.27 65.5 48.4 No No
5 empty 2.42 68.3 31.8 No No
6 empty 2.18 68.7 29.5 No No
7 empty 2.23 69.1 23.8 No No
8 empty 2.34 70.2 27.3 No No
9 empty 1.79 66.6 22.6 No No
10 empty 2.35 61 26.2 No No
3S2D_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.9 68.3 87.4 Yes Yes
2 empty 1.41 69.6 66.8 No No
3 empty 2.03 67.2 43.6 No No
4 empty 2.25 61.2 51.2 No No
5 empty 1.85 69.4 32.9 No No
6 empty .89 71.5 36.6 No No
7 empty 2.33 49.9 30.5 No No
8 empty 2.51 64.8 28 No No
9 empty 1.91 74.3 28.7 No No
10 empty 2.07 67.2 35.2 No No
4A3J_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.99 67 87.3 Yes Yes
2 empty 1.45 68.7 106.6 No No
3 empty 2.12 67.8 33.4 No No
4 empty 2.29 68.4 25.8 No No
5 empty 2.31 51.5 30.6 No No
6 empty 1.97 47.2 23.3 No No
7 empty 2.25 59.8 26.4 No No
8 empty 2.23 61.3 23.1 No No
9 empty 2.06 90 20.6 Yes No
10 empty 1.91 61 17.6 No No
3HOU_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.49 67.3 102.5 Yes Yes
2 empty 1.1 69.1 47.8 No No
3 empty 2.14 66 37.7 No No
4 empty 2.01 65.9 51.3 No No
5 empty 2.02 70.8 31.1 No No
6 empty 2 65.1 29.8 No No
7 empty 2.45 60 36.6 No No
8 empty 2.28 66 27.4 No No
9 empty 2.18 66.5 22.3 No No
10 empty 2.01 61.2 20.6 No No
1Y1W_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.5 67.1 104 Yes Yes
2 empty 1 67.7 54.2 No No
3 empty 2.15 68.6 35.7 No No
4 empty 2.13 64.1 36.4 No No
5 empty 2.13 68.8 22 No No
6 empty 2.43 63.6 24.3 No No
7 empty 1.67 63.6 21.5 No No
8 empty 2.32 63.4 23.3 No No
9 empty 2.36 70.9 17.4 No No
10 empty 2.16 62.4 21.1 No No
5W51_A DNA-directed RNA polymerase II subunit RPB1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.54 63.2 70.8 Yes No
2 empty 1.48 70 63.4 No No
3 empty 2.18 60.2 37.5 No No
4 empty 1.99 61.1 30.8 No No
5 bound 2.09 68.8 40.3 No No
6 empty 1.93 67.2 32.3 No No
7 empty .98 67.3 34 No No
8 empty 2.17 62.5 35.5 No No
9 empty 2.26 58 30.5 No No
10 empty 1.88 73.1 22.1 No No
3RZO_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.48 68.1 103.9 Yes Yes
2 empty 2.34 67.2 39.6 No No
3 empty .96 71.1 37.4 No No
4 empty 2.33 49.1 30.7 No No
5 empty 2.04 66.3 35.4 No No
6 empty 2.55 62.4 31 No No
7 empty 2.11 72 18.6 No No
8 empty 2.18 64.7 21.8 No No
9 empty 2.59 66.3 23.2 No No
10 empty 2.03 60.6 24.5 No No
3HOU_M DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.48 67.4 102 Yes Yes
2 empty 1.9 74.1 36.3 No No
3 empty 1.21 68.2 45.3 No No
4 empty 2.07 63.3 38.2 No No
5 empty 2.2 67.2 39.2 No No
6 empty 2.03 66.6 48.2 No No
7 empty 1.97 71.6 32.5 No No
8 empty 2.05 66.9 32.3 No No
9 empty 2.58 60.5 37.9 No No
10 empty 2.16 67 23 No No
5VKO_B DNA-directed RNA polymerase II subunit RPB1 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.21 47.4 14.9 No No
2 empty 2.41 55.8 14.4 No No
3 empty 2.71 54 13.6 No No
4 empty 3.22 53.7 8.8 No No
5 empty 2.25 44.8 6.9 No No
6 empty 2.16 44.1 6.2 No No
1R5U_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.97 69.1 69.6 Yes Yes
2 empty 1.48 64.9 78.1 No No
3 empty 2.07 67.6 49.8 No No
4 empty 2.11 71.8 36.7 No No
5 empty 2.12 67.8 53.2 No No
6 empty .93 68.1 39 No No
7 empty 2.19 67.8 31.1 No No
8 empty 2.38 60.7 35.6 No No
9 empty 2.04 69.4 22 No No
10 empty 1.87 65.4 28.4 No No
5C4A_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.93 67.9 93.9 Yes Yes
2 empty 2.19 74 42 No No
3 empty 1 65.3 46.7 No No
4 empty 1.95 64.5 31.9 No No
5 empty 2.02 53.1 32.3 No No
6 empty 1.96 67.8 32.6 No No
7 empty 2.04 62 26.5 No No
8 empty 1.97 62.6 34.3 No No
9 empty 2.41 60.7 28.1 No No
10 empty 2.01 59.4 22.7 No No
1R9S_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.48 67.7 104.3 Yes Yes
2 empty 2.09 61.3 40.3 No No
3 empty 2.21 67.7 30.5 No No
4 empty 2.18 66.8 32.3 No No
5 empty 2.11 72.8 27.8 No No
6 empty 2.61 64 29.5 No No
7 empty 2.51 63.5 29.4 No No
8 empty 2.17 69 27.1 No No
9 empty 2.18 66.3 25.4 No No
10 empty 2.19 73.8 20.8 No No
1I3Q_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.05 68.3 109.9 Yes Yes
2 empty 2.26 66 40.9 No No
3 empty 1.05 70.8 39.8 No No
4 empty 2.21 72.7 31 No No
5 empty 2.28 70.3 34 No No
6 empty 2.01 69.8 20.1 No No
7 empty 2.4 64.3 26.3 No No
8 empty 2.24 70.1 33.3 No No
9 empty 2.38 61.8 28.3 No No
10 empty 1.95 67.8 20.3 No No
2E2I_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.45 68.1 91.2 Yes Yes
2 empty 2.27 67.2 37.1 No No
3 empty .92 71.7 40.8 No No
4 empty 1.97 64.1 38 No No
5 empty 2.22 56.1 39.5 No No
6 empty 1.84 76.2 25.1 No No
7 empty 2.25 68.2 35.6 No No
8 empty 2.42 54.1 20.4 No No
9 empty 2.17 66.6 33.7 No No
10 empty 2.53 64 32.3 No No
1TWH_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.92 68.1 77.6 Yes Yes
2 empty 1.83 67.2 61.2 No No
3 empty 2.08 58.8 35.2 No No
4 empty 2.06 59 31.2 No No
5 empty 2.36 58.4 32.9 No No
6 empty 1.17 70 31.9 No No
7 empty 1.86 62.5 25.2 No No
8 empty 2.11 62.6 23.2 No No
9 empty 2.28 68.2 26.1 No No
10 empty 2.09 60.9 24.7 No No
4A93_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.32 67.9 97.8 Yes Yes
2 empty 1.07 66.4 46.6 No No
3 empty 2.13 67.4 32.8 No No
4 empty 2.3 54.3 30.8 No No
5 empty 2.37 72.2 26.3 No No
6 empty 2.06 63.9 34.5 No No
7 empty 1.95 66 22.4 No No
8 empty 1.97 51.7 19.4 No No
9 empty 2.15 61.1 27 No No
10 empty 2.06 58.3 27.9 No No
3GTG_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.92 69.4 104.3 Yes Yes
2 empty .92 64.8 50 No No
3 empty 2.62 69.2 36.6 No No
4 empty 2.58 65.4 32.6 No No
5 empty 1.82 66.7 36.7 No No
6 empty 2.07 52.4 39 No No
7 empty 2.16 69.9 35.9 No No
8 empty 2.21 65.3 34.2 No No
9 empty 2.41 64 25.4 No No
10 empty 1.88 72.7 22.9 No No
1SFO_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.42 68.4 91 Yes Yes
2 empty .92 69.2 50.1 No No
3 empty 2.13 70.2 49.2 No No
4 empty 2.27 66.9 43.9 No No
5 empty 2.2 67.9 48.6 No No
6 empty 1.97 61.7 40.7 No No
7 empty 2.21 46.1 37.6 No No
8 empty 1.92 83.5 29.8 No No
9 empty 2.28 49.7 20 No No
10 empty 1.73 65.5 26.7 No No
5VVS_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.01 71 108.4 Yes Yes
2 empty 1.98 67.3 40 No No
3 empty 1.96 69.1 50.7 No No
4 empty 1.94 60.8 25 No No
5 empty 2.3 66.8 22.1 No No
6 empty 1.86 76.8 25.2 No No
7 empty 1.6 80.8 18.4 No No
8 empty 1.86 70.1 21.3 No No
9 empty 1.76 69.9 17.1 No No
10 empty 1.9 53.6 17.3 No No
4A3L_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.04 67.5 83.2 Yes Yes
2 empty 1.4 70.1 74.6 No No
3 empty .99 66.1 45.5 No No
4 empty 2.23 75.4 36.6 No No
5 empty 1.88 64.1 41.4 No No
6 empty 2.24 68.2 36.6 No No
7 empty 2.32 53.7 30.7 No No
8 empty 1.91 67 29.3 No No
9 empty 2.18 68.9 36 No No
10 empty 2.23 63.6 34.6 No No
3S15_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.46 69.2 90.6 Yes Yes
2 empty 2.49 66.1 37.8 No No
3 empty 1.93 69.9 33 No No
4 empty 1.9 64.1 38.3 No No
5 empty 2.3 64.2 39.6 No No
6 empty 2.14 62.5 46.7 No No
7 empty .91 66.6 41.1 No No
8 empty 2.56 64.8 32 No No
9 empty 2.1 49.6 30.6 No No
10 empty 2.06 70.5 34.2 No No
5U5Q_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.45 68.6 102.6 Yes Yes
2 empty 1.98 65.6 42.1 No No
3 empty 2.14 67.2 36.2 No No
4 empty 2.41 53.8 40.4 No No
5 empty 2.07 68.1 35 No No
6 empty 2.14 66.9 40.8 No No
7 empty 2.18 69.7 35.2 No No
8 empty 2.35 65.6 26.3 No No
9 empty 1.91 64.3 25 No No
10 empty 2.2 69 28.1 No No
3CQZ_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.19 68.2 101.9 Yes Yes
2 empty 2.22 65 29.8 No No
3 empty 2.04 64.5 26.9 No No
4 empty 2.11 71 39.2 No No
5 empty 2.09 69.1 24.8 No No
6 empty 2.11 60 30.9 No No
7 empty 2.06 63.8 26.4 No No
8 empty 2.13 68.5 23.9 No No
9 empty 2.26 66 25.2 No No
10 empty 2.17 43.4 18.6 No No
1TWA_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.9 67.7 74.8 Yes Yes
2 empty 1.61 67 61.3 No No
3 empty 2.05 63.6 35.2 No No
4 empty 2.06 58.7 32.3 No No
5 empty 2.18 58.5 33.2 No No
6 empty 2.31 59.9 32.5 No No
7 empty 1.58 61.1 19.3 No No
8 empty 2.04 61.5 29.2 No No
9 empty 1.06 75 20.5 No No
10 empty 2.2 67.2 23.8 No No
2NVY_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.82 69.5 78.2 Yes Yes
2 empty 1.55 67.4 68 No No
3 empty 2.32 71.3 45 No No
4 empty 2.42 69 36.3 No No
5 empty 1.97 62.2 43 No No
6 empty 1.88 72.1 32.9 No No
7 empty .87 69.6 48.2 No No
8 empty 2.04 66.3 24 No No
9 empty 2.05 67.5 34.8 No No
10 empty 2.4 65.5 25.8 No No
1I6H_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.01 67 104.2 Yes Yes
2 empty 1.03 68 45 No No
3 empty 2.12 65.1 39 No No
4 empty 2.48 67.1 39.4 No No
5 empty 2.06 65.9 37.5 No No
6 empty 2.09 75.4 28.6 No No
7 empty 2.21 66.3 38.6 No No
8 empty 2.2 66.7 33.4 No No
9 empty 2.35 66.7 28.2 No No
10 empty 2.58 61.6 29.7 No No
2NVT_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.46 68.8 89.4 Yes Yes
2 empty 2.01 70.4 33.8 No No
3 empty 2.38 65.3 35.8 No No
4 empty 1.72 63 36.1 No No
5 empty .93 68.5 42.5 No No
6 empty 1.86 68.3 38.8 No No
7 empty 2.09 69.6 34.8 No No
8 empty 2.24 69.2 29 No No
9 empty 2.25 49.2 32.4 No No
10 empty 2.16 68 37.9 No No
1TWF_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.13 68.2 88.2 Yes Yes
2 empty 1.64 69.1 89.4 No No
3 empty 1.89 71.1 32 No No
4 empty 1.99 61.4 40.4 No No
5 empty 1.09 76.1 31 No No
6 empty 2.38 63.8 42.5 No No
7 empty 2.24 67.1 26.3 No No
8 empty 2.14 68.3 35.1 No No
9 empty 2.38 63.4 33.3 No No
10 empty 2.14 70.1 24.8 No No
3S1M_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.53 68.8 94.9 Yes Yes
2 empty 2.29 64.8 38.7 No No
3 empty 1.85 70.9 33.2 No No
4 empty .92 69.1 30.3 No No
5 empty 2.38 52.9 31 No No
6 empty 2.58 62.3 31 No No
7 empty 2.07 66.1 36.3 No No
8 empty 2.06 65.8 35.4 No No
9 empty 2.03 66.4 22.9 No No
10 empty 2.28 53.3 19 No No
2JA7_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.02 67 106.4 Yes Yes
2 empty .97 66.4 55.2 No No
3 empty 2.13 70 35.5 No No
4 empty 2.04 70.7 29.5 No No
5 empty 2.33 62.6 29.2 No No
6 empty 2.13 68.9 34.9 No No
7 empty 2.12 64.8 36.3 No No
8 empty 2.09 69.4 18.1 No No
9 empty 2.23 64.4 20.5 No No
10 empty 1.81 65.3 18.3 No No
5C4X_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.01 70 103.1 Yes Yes
2 empty 1.94 66.1 30.4 No No
3 empty 1 69.9 40.3 No No
4 empty 2.18 53.1 33.3 No No
5 empty 2.01 63.4 27.2 No No
6 empty 1.93 68.4 35.5 No No
7 empty 2.21 67.3 26.7 No No
8 empty 2.46 65.1 29.6 No No
9 empty 2.21 60.5 25.1 No No
10 empty 1.98 60.3 23.9 No No
3QT1_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.38 67.4 103.2 Yes Yes
2 empty 2.06 66.5 40.6 No No
3 empty 1.29 69.8 45.8 No No
4 empty 2.08 69 28.5 No No
5 empty 1.97 67.5 47.5 No No
6 empty 2.12 66.1 31.4 No No
7 empty 2.19 67 23.2 No No
8 empty 2.29 63.4 22.7 No No
9 empty 2.42 64.9 16.3 No No
10 empty 2.1 72.2 22.9 No No
4BY1_A DNA-directed RNA polymerase II subunit RPB1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.37 65.7 102.3 Yes No
2 empty 1.03 65 52.8 No No
3 empty 1.76 69 36.4 No No
4 empty 2.1 65.6 37.1 No No
5 empty 1.92 64.8 18.5 No No
6 empty 2.1 63.8 21.4 No No
7 empty 1.95 70.2 23.7 No No
8 empty 1.76 62 20.9 No No
9 empty 2.07 89.2 21.2 Yes No
10 empty 1.83 60.1 20.1 No No
5W4U_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.3 68.6 92.1 Yes Yes
2 empty .97 67.7 49.5 No No
3 empty 2.02 63.2 41.5 No No
4 empty 2.41 60.9 29.9 No No
5 empty 2.17 50.9 31.2 No No
6 empty 2.18 68.3 33 No No
7 empty 2.3 52.6 20.8 No No
8 empty 2.06 64.6 27 No No
9 empty 2.16 60.3 31.1 No No
10 empty 2.56 67.1 22.6 No No
3GTL_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.46 69.1 93.3 Yes Yes
2 empty 1.96 65 57.1 No No
3 empty 1.88 64.1 43.2 No No
4 empty 2.01 66.9 34.9 No No
5 empty 1.03 69 43.9 No No
6 empty 1.95 77.8 20.7 No No
7 empty 2.17 69.2 32.7 No No
8 empty 2.3 43.9 26.5 No No
9 empty 2.24 43.9 23.9 No No
10 empty 2.53 66.5 32.7 No No
4Y7N_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.47 68.6 95.1 Yes Yes
2 empty 2.03 70.7 49.4 No No
3 empty 2.15 69.4 37 No No
4 empty .87 70.5 53.6 No No
5 empty 1.96 64.7 38.7 No No
6 empty 2.19 50.3 31.5 No No
7 empty 2.05 68.1 32.4 No No
8 empty 2.2 53.6 21.1 No No
9 empty 2.2 66 18.7 No No
10 empty 2.46 64.6 28.2 No No
4V1N_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.52 68.1 99 Yes Yes
2 empty 1.81 69.5 36.2 No No
3 empty 1.98 63.5 40 No No
4 empty 1.93 61.3 43.6 No No
5 empty 2.33 68 36.4 No No
6 empty 2.01 64.7 27.5 No No
7 empty 2.45 52.6 31.4 No No
8 empty 2.34 63.4 25.8 No No
9 empty 2.19 51.7 19.5 No No
10 empty 2.1 56 24.5 No No
3S17_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.37 68.3 92.7 Yes Yes
2 empty 2.41 66.3 37.3 No No
3 empty 1.93 69.3 32.9 No No
4 empty .98 69.7 37.4 No No
5 empty 2.21 65.5 40.7 No No
6 empty 2.35 50.5 32.3 No No
7 empty 2.18 70.3 33.6 No No
8 empty 1.92 72 24.1 No No
9 empty 2.39 67.3 38.9 No No
10 empty 2.11 67.5 32.4 No No
2VUM_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.68 67.7 105.1 Yes Yes
2 empty .93 67.3 51.7 No No
3 empty 2.41 70.1 41.3 No No
4 empty 2.2 67.1 40.5 No No
5 empty 2.52 63.9 32.4 No No
6 empty 1.85 70.5 21.7 No No
7 empty 2.12 64.2 36.2 No No
8 empty 2 64.2 21.3 No No
9 empty 2.03 62.2 18.5 No No
10 empty 2.42 63.2 23.1 No No
3I4M_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.63 67.1 100.5 Yes Yes
2 empty .95 65.9 54.1 No No
3 empty 2.07 66.7 51.3 No No
4 empty 2.29 67.6 37.1 No No
5 empty 1.88 65.4 31.1 No No
6 empty 1.79 65.7 20.9 No No
7 empty 2.21 58.5 23.1 No No
8 empty 2.25 61.9 22.3 No No
9 empty 2.16 68.6 24.2 No No
10 empty 2.18 64.5 24.5 No No
6GYK_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.61 67.9 103.3 Yes Yes
2 empty 2.06 66 78.8 No No
3 empty 2.1 67.7 43.7 No No
4 empty 2.36 53.4 45.6 No No
5 empty 2.09 67.9 25.3 No No
6 empty 2.24 69.9 33.9 No No
7 empty 2.07 65.5 34.9 No No
8 empty 2.34 67.3 26.3 No No
9 empty 2.02 68 20.4 No No
10 empty 2.34 59.7 28.6 No No
5FZ5_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.51 68.6 97.4 Yes Yes
2 empty 1.56 68.6 84.2 No No
3 empty 2.4 70.6 56.2 No No
4 empty 2.02 66.9 45.7 No No
5 empty 2.48 59.7 36.6 No No
6 empty 1.96 72 26.7 No No
7 empty 2.23 51.7 31.4 No No
8 empty 2.15 70.2 33.1 No No
9 empty 2.07 63.4 31.8 No No
10 empty 2.03 67.4 27.1 No No
4Y52_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.49 68.9 108.9 Yes Yes
2 empty .88 67.8 49.6 No No
3 empty 2.37 65 47.7 No No
4 empty 2.01 67.4 31.8 No No
5 empty 2.18 65.7 30 No No
6 empty 2.19 50.1 36.5 No No
7 empty 2.26 64.3 23.6 No No
8 empty 2.04 70.9 29.4 No No
9 empty 2.13 51.7 20.1 No No
10 empty 2.2 62 32.3 No No
3RZD_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.36 68.1 91.6 Yes Yes
2 empty .93 69.8 49.5 No No
3 empty 2.01 69 32 No No
4 empty 2.34 55.5 31.5 No No
5 empty 2.1 67.8 38 No No
6 empty 1.86 65.3 27.9 No No
7 empty 2.56 62.4 31.4 No No
8 empty 1.95 62 30.3 No No
9 empty 2.09 67.2 35.3 No No
10 empty 2.42 69 36.7 No No
4A3D_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.29 68.2 90.7 Yes Yes
2 empty .99 67.5 46.3 No No
3 empty 1.72 69.8 35.2 No No
4 empty 1.8 63.3 43.6 No No
5 empty 2.07 68.8 36.7 No No
6 empty 2.17 65.8 44.6 No No
7 empty 2.39 55.7 29 No No
8 empty 1.91 66.8 28.6 No No
9 empty 2.37 64.4 26.8 No No
10 empty 1.97 59.3 33 No No
6BLO_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.51 68.3 93 Yes Yes
2 empty 1.92 64.7 40.5 No No
3 empty 1.09 69.7 43.4 No No
4 empty 1.97 68 30.8 No No
5 empty 2.07 53 38.2 No No
6 empty 1.81 61.4 40.4 No No
7 empty 2.27 63 26.8 No No
8 empty 2.09 68.8 32.7 No No
9 empty 2.23 51.3 20.7 No No
10 empty 2.14 65.1 33.2 No No
3S14_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.49 68 93.9 Yes Yes
2 empty 2.22 67.1 37.6 No No
3 empty 1.91 68.3 33 No No
4 empty 1.01 70.6 35.4 No No
5 empty 2.33 50.2 31.1 No No
6 empty 2.46 63.7 28.5 No No
7 empty 2.21 69.1 34.2 No No
8 empty 1.7 74.2 28.3 No No
9 empty 2.01 63.3 21.9 No No
10 empty 2.24 52.7 19.3 No No
4A3E_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.51 68.3 100.1 Yes Yes
2 empty 1.07 67.7 46.8 No No
3 empty 1.66 70.5 42.5 No No
4 empty 2.26 57.5 47.4 No No
5 empty 1.88 60.8 40.5 No No
6 empty 2.2 67.7 37.9 No No
7 empty 2.26 69 38.4 No No
8 empty 2.51 65.4 31.6 No No
9 empty 1.92 69.2 17.3 No No
10 empty 2.32 63.9 27.8 No No
1TWC_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.68 68.3 96.6 Yes Yes
2 empty 2.21 61.3 36.1 No No
3 empty 1.81 60.2 43.4 No No
4 empty 2.11 66.9 44.6 No No
5 empty 1.85 63 33.7 No No
6 empty 2.21 67.5 39.4 No No
7 empty 2.08 61.6 26.5 No No
8 empty 2.14 54.3 26.9 No No
9 empty 2.27 65.1 36.2 No No
10 empty 2.08 65.9 35.9 No No
3HOX_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.45 67.6 103.8 Yes Yes
2 empty 1.07 67.9 44.9 No No
3 empty 2.06 66.1 40.3 No No
4 empty 2.02 66 47.4 No No
5 empty 2.45 61.4 29.8 No No
6 empty 1.95 66.1 22 No No
7 empty 2.12 62.1 32.1 No No
8 empty 1.95 63.2 21.4 No No
9 empty 2.17 64.5 25.6 No No
10 empty 2.06 67.5 18.7 No No
3S16_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.43 69 95.3 Yes Yes
2 empty 2.34 67.6 37.1 No No
3 empty 2.33 57.2 41.2 No No
4 empty 2.54 65.4 31.5 No No
5 empty 2.2 59.7 37.3 No No
6 empty 2.11 67.9 35.8 No No
7 empty 1.8 65.9 23.9 No No
8 empty 2.05 51.4 20.3 No No
9 empty 2.13 68.7 24.4 No No
10 empty 2.58 59.3 21.4 No No
3S1R_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.53 67.7 109.6 Yes Yes
2 empty 1.88 68.3 32 No No
3 empty 2.28 73.1 36.5 No No
4 empty .91 70.8 40.2 No No
5 empty 2.32 55.6 31.1 No No
6 empty 1.98 67.9 34.8 No No
7 empty 2.45 59.2 25.2 No No
8 empty 1.81 64.4 26.7 No No
9 empty 1.82 78.9 26 No No
10 empty 2.03 64.2 31.4 No No
6O6C_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.04 69.5 92.9 Yes Yes
2 empty 2.17 66.8 93.5 No No
3 empty 1.07 67 50.7 No No
4 empty 2.09 70.2 32.5 No No
5 empty 1.85 68.8 19.5 No No
6 empty 1.8 63.4 22.3 No No
7 empty 2.51 63.2 22.9 No No
8 empty 1.62 72 19.1 No No
9 empty 1.86 59.5 17.5 No No
10 empty 2.52 64.7 25.4 No No
2B63_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.52 68.3 105.2 Yes Yes
2 empty 1.05 67.5 49.6 No No
3 empty 2.07 63.4 41.2 No No
4 empty 2.2 67.7 32.8 No No
5 empty 2.15 66.4 31.6 No No
6 empty 2.23 70.8 33.6 No No
7 empty 2.65 67.3 33.2 No No
8 empty 2.19 64.6 35.2 No No
9 empty 2.36 63.1 22.4 No No
10 empty 2.4 65.7 21.6 No No
3HOY_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.48 67.1 100.9 Yes Yes
2 empty 2.05 70.2 37.4 No No
3 empty 2.27 62 32.6 No No
4 empty 2.02 65.7 48.1 No No
5 empty 2.05 68.8 34.2 No No
6 empty 1 71.1 37.9 No No
7 empty 2.27 67.6 31.7 No No
8 empty 2.21 60.8 24.7 No No
9 empty 2.17 60.8 24.2 No No
10 empty 2.2 66.6 30.7 No No
3M4O_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.37 67.3 103.9 Yes Yes
2 empty 2.23 67.7 37.9 No No
3 empty 1.91 70.3 32 No No
4 empty 2.38 52.1 39.6 No No
5 empty .88 69.5 39.2 No No
6 empty 2.69 65.6 36.1 No No
7 empty 2.18 68.2 33.7 No No
8 empty 2.36 60.8 31 No No
9 empty 2.36 67.9 27.8 No No
10 empty 1.91 66.4 20.8 No No
4A3C_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.3 68 93 Yes Yes
2 empty 1.65 67.8 54.3 No No
3 empty .94 67.8 46.5 No No
4 empty 2.4 54.5 31.4 No No
5 empty 2.12 68.9 34.5 No No
6 empty 2.26 69.1 26.6 No No
7 empty 2.27 62.2 26.6 No No
8 empty 1.92 50.8 19.5 No No
9 empty 1.85 64.3 17.1 No No
10 empty 2.02 56.9 23.8 No No
3K7A_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.31 67.7 102.8 Yes Yes
2 empty 2.13 66.9 52 No No
3 empty 2.17 74.4 29.4 No No
4 empty 2.16 63.3 37.6 No No
5 empty .95 70.9 38.7 No No
6 empty 2.37 66.8 29.1 No No
7 empty 2.06 68.4 19.1 No No
8 empty 2.41 64.1 26.7 No No
9 empty 2.25 68.8 27.1 No No
10 empty 2.43 63.7 27.3 No No
3PO3_A DNA-directed RNA polymerase II subunit RPB1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.42 65.7 68.7 Yes No
2 bound 1.54 70.2 55.2 No No
3 empty 1.91 67.2 37.7 No No
4 empty 1.94 62 46.4 No No
5 empty 1.9 55.8 33.5 No No
6 empty 1 68 37.4 No No
7 empty 2.21 57.9 31.9 No No
8 empty 2.11 63.9 36.8 No No
9 empty 1.82 63.5 22.7 No No
10 empty 2.25 57.2 28.8 No No
1NIK_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.97 68.4 103 Yes Yes
2 empty 2.1 61.1 37.9 No No
3 empty 2.17 67.6 30.1 No No
4 empty 1.99 67.5 33.5 No No
5 empty 2.42 62 34.8 No No
6 empty 2.22 66.9 38 No No
7 empty 2.49 65.2 28.9 No No
8 empty 2.24 66.7 26.7 No No
9 empty 2.23 59.4 23.4 No No
10 empty 1.92 67 19.5 No No
3HOZ_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.21 67.6 104.2 Yes Yes
2 empty 1.97 71.3 35.6 No No
3 empty 2.01 69.3 41.6 No No
4 empty 2.01 72.5 31.6 No No
5 empty 2.03 66.6 49 No No
6 empty 2.18 64.7 22.5 No No
7 empty 1.95 65.4 22.1 No No
8 empty 2.28 67.3 19.4 No No
9 empty 2.31 66 23.9 No No
10 empty 2.07 59.3 23 No No
4X67_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.22 67.8 88.7 Yes Yes
2 empty 1.54 68.3 81.5 No No
3 empty 2.02 64.7 60 No No
4 empty 1.09 71.2 40 No No
5 empty 2.16 70.4 39.3 No No
6 empty 2.32 48.5 19.2 No No
7 empty 2.31 36.3 27.1 No No
8 empty 2.22 61.4 24.3 No No
9 empty 1.94 63.9 24.9 No No
10 empty 2.18 57.1 29.5 No No
5FYW_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.5 68.5 97.9 Yes Yes
2 empty 1.83 68.2 84.1 No No
3 empty 2.06 67.8 45.8 No No
4 empty 2.45 70.3 51.6 No No
5 empty 2.18 55.3 46.1 No No
6 empty 2.47 59.7 36.5 No No
7 empty 1.95 72.5 27 No No
8 empty 2.08 67.5 27.2 No No
9 empty 2.15 70.9 32.9 No No
10 empty 2.34 53.3 19 No No
3GTJ_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.57 68.9 109 Yes Yes
2 empty 2.47 64.6 62.1 No No
3 empty 2.67 69.1 39.8 No No
4 empty 2.19 66.2 58 No No
5 empty 1.94 66 37.1 No No
6 empty .89 75.1 31.8 No No
7 empty 2.45 55.4 38.4 No No
8 empty 2.25 51.7 29.9 No No
9 empty 2.31 66.8 27.8 No No
10 empty 2.09 63.1 23 No No
2R93_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.52 67.6 104.1 Yes Yes
2 empty .97 68.2 52.9 No No
3 empty 2.06 64.9 39 No No
4 empty 2.11 70 44.4 No No
5 empty 2.44 66.4 38.3 No No
6 empty 2.09 66.3 23.3 No No
7 empty 2.39 66.8 30.6 No No
8 empty 2.29 62.3 22.5 No No
9 empty 2.21 66.4 17.7 No No
10 empty 1.92 62.8 22.6 No No
3GTP_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.56 68.8 92.5 Yes Yes
2 empty 2.17 69.3 41.9 No No
3 empty 2.15 69.5 49.1 No No
4 empty 1.09 69.3 46.3 No No
5 empty 2.16 50.2 38.1 No No
6 empty 2.37 65.4 25.5 No No
7 empty 2.11 68.6 33.6 No No
8 empty 2.31 67 24 No No
9 empty 2.34 49.7 22.6 No No
10 empty 2.12 66.9 35.3 No No
3I4N_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.07 67.4 106.3 Yes Yes
2 empty 2.07 67.3 48.7 No No
3 empty 1.97 65.4 40.9 No No
4 empty 2.33 63.2 38.4 No No
5 empty 1.96 65.7 30.9 No No
6 empty 2 62.6 22.4 No No
7 empty 2.45 71.1 21.9 No No
8 empty 1.99 61 21.4 No No
9 empty 2.17 60.6 21 No No
10 empty 2.28 62.6 22.5 No No
4BY7_A DNA-directed RNA polymerase II subunit RPB1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.45 64.6 74.7 Yes No
2 empty 1.59 66.8 56.6 No No
3 empty .87 60.9 48.1 No No
4 empty 1.93 66.9 31.4 No No
5 empty 1.75 57.9 29.7 No No
6 empty 2.13 56.4 30.1 No No
7 empty 1.95 64.8 34.6 No No
8 empty 1.73 71.9 24.5 No No
9 empty 1.99 70 17.6 No No
10 empty 2.11 65 18 No No
3GTO_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.04 68.8 85.9 Yes Yes
2 empty 1.55 68.8 73.2 No No
3 empty 2.06 68 57.7 No No
4 empty 1.89 66.4 37.1 No No
5 empty .95 71.2 39 No No
6 empty 2.17 68.4 41.3 No No
7 empty 2.19 51.9 37.4 No No
8 empty 2.13 75.5 27.1 No No
9 empty 2.42 67.5 21.7 No No
10 empty 2.37 48.6 21.6 No No
3M3Y_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.47 68.5 103.4 Yes Yes
2 empty 2.19 67.1 41.9 No No
3 empty 2.27 58.7 42.6 No No
4 empty .9 69.8 39.9 No No
5 empty 2.33 68.2 49.9 No No
6 empty 2.36 49.8 34.8 No No
7 empty 1.91 65.4 28.6 No No
8 empty 2.49 63.4 33.1 No No
9 empty 1.77 64.6 27.3 No No
10 empty 2.29 70.3 23.5 No No
3GTK_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.38 68.9 114.6 Yes Yes
2 empty 2.46 64.6 42.2 No No
3 empty 2.37 51.9 41.9 No No
4 empty 2.66 71 31.3 No No
5 empty 1.88 66.7 37.5 No No
6 empty 2.06 66.1 34.7 No No
7 empty 2.22 63.9 25.2 No No
8 empty 1.84 55.7 19.6 No No
9 empty 2.04 56.9 25.1 No No
10 empty 2.51 65.2 17.6 No No
2JA5_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.98 67.4 103.8 Yes Yes
2 empty .99 68.5 55 No No
3 empty 2.25 59.5 28.8 No No
4 empty 2.14 69.4 36.4 No No
5 empty 2.11 65.1 36 No No
6 empty 2.07 69 21.6 No No
7 empty 2.24 67.1 30.1 No No
8 empty 2.27 63.4 20.3 No No
9 empty 1.96 63.6 21.3 No No
10 empty 2.28 64.2 22.6 No No
2JA8_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.02 67.1 103.3 Yes Yes
2 empty .93 68.2 55.7 No No
3 empty 2.05 71 38.6 No No
4 empty 2.1 65 41.1 No No
5 empty 2.08 70.8 30.3 No No
6 empty 2.14 68.2 35.3 No No
7 empty 2.13 64.7 35 No No
8 empty 2.21 62.7 28.8 No No
9 empty 2.08 69.1 19.5 No No
10 empty 2.24 67 31.6 No No
2E2H_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.83 68.8 112.9 Yes Yes
2 empty 2.27 63.6 44.1 No No
3 empty 2.51 71.3 33.1 No No
4 empty 2.23 55.6 24.2 No No
5 empty 2.28 53 22.4 No No
6 empty 1.62 67.9 27.5 No No
7 empty 2.17 61.3 25.9 No No
8 empty 2.17 60.8 24.1 No No
9 empty 2.27 64.2 19.8 No No
10 empty 2.38 65.6 17.5 No No
2R92_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.98 67.7 106.1 Yes Yes
2 empty 1.02 67 51.7 No No
3 empty 2.06 67.9 47.2 No No
4 empty 2.44 65.6 36.7 No No
5 empty 2.14 67.1 23.1 No No
6 empty 2.19 64.6 21.8 No No
7 empty 1.97 63.8 21.3 No No
8 empty 2.16 61.7 20.2 No No
9 empty 2.45 74.4 12.8 No No
10 empty 2.01 63.3 17.5 No No
6BM2_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.88 68.9 89.5 Yes Yes
2 empty 1.95 63.7 40.2 No No
3 empty 1.93 68.2 31 No No
4 empty .98 69.7 44.4 No No
5 empty 2.06 54.4 39.4 No No
6 empty 2.14 67.7 48.9 No No
7 empty 2.29 65 30.3 No No
8 empty 2.34 63.9 31.1 No No
9 empty 2.21 50.1 21.1 No No
10 empty 2.48 67.7 23.6 No No
2JA6_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.55 67.9 106.2 Yes Yes
2 empty 2.04 65.9 41.6 No No
3 empty 2.13 66.5 47.9 No No
4 empty 2.3 59.8 27.3 No No
5 empty 2.15 67.4 22.9 No No
6 empty 2.01 64.2 20.9 No No
7 empty 2.25 62.7 22.5 No No
8 empty 2.22 63.2 20.3 No No
9 empty 2.17 66 24.7 No No
10 empty 2.03 68.9 16.9 No No
4X6A_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.36 67.9 92.4 Yes Yes
2 empty 2.41 67.5 43.9 No No
3 empty 2.3 49.9 47.8 No No
4 empty .99 69.9 42.3 No No
5 empty 2.03 74.9 33.4 No No
6 empty 2.02 75 29.2 No No
7 empty 2.62 65.8 30.3 No No
8 empty 2.37 70.2 29.8 No No
9 empty 2.25 65.4 26.6 No No
10 empty 2.31 58.9 29.9 No No
1K83_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.09 69.9 101.6 Yes Yes
2 empty 1.86 70.6 33.5 No No
3 empty .96 69.2 39.2 No No
4 empty 1.95 60.7 43.4 No No
5 empty 2.2 66.4 50.6 No No
6 empty 2.02 61.2 25.2 No No
7 empty 2.06 62.6 30.7 No No
8 empty 2.54 61.5 26.9 No No
9 empty 2.53 64.8 28 No No
10 empty 2.19 68.4 23.2 No No
6GYL_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.5 67.7 83 Yes Yes
2 empty 1.56 64.8 78.8 No No
3 empty 1.01 66.8 48.4 No No
4 empty 2.05 69.6 41.2 No No
5 empty 2.12 52.8 36.7 No No
6 empty 2.23 68.4 25.4 No No
7 empty 2.21 70.2 32.4 No No
8 empty 2.08 64.7 26.6 No No
9 empty 2.03 68.1 20.1 No No
10 empty 2.3 62.9 21.9 No No
1WCM_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.52 68.1 107.6 Yes Yes
2 empty 1.99 67.5 38.4 No No
3 empty 2.15 66.7 48.4 No No
4 empty 2.13 67.4 18.7 No No
5 empty 2.23 64.3 22.6 No No
6 empty 2.33 66.3 18.1 No No
7 empty 2.36 74.1 15 No No
8 empty 1.91 69.1 16.9 No No
9 empty 1.79 61.9 14.9 No No
10 empty 2.61 62.3 17.6 No No
2NVZ_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.78 70.4 112 Yes Yes
2 empty 2.02 63.5 34.2 No No
3 empty 2.33 67.2 35.9 No No
4 empty .9 73.7 32.5 No No
5 empty 2.26 61.8 31 No No
6 empty 2.41 72.9 21.4 No No
7 empty 2.49 59.7 28.6 No No
8 empty 2.3 55.6 22.1 No No
9 empty 2.22 53.7 19.8 No No
10 empty 2.51 60.6 29.2 No No
4BBS_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.52 68.3 91 Yes Yes
2 empty 2.2 72.5 37.5 No No
3 empty 1.94 64.7 37.8 No No
4 empty 1.1 70.6 39.9 No No
5 empty 2.08 64.9 26.3 No No
6 empty 2.47 53.5 30.1 No No
7 empty 2.12 69.4 32.7 No No
8 empty 2.09 50.8 19.3 No No
9 empty 2.1 60 26 No No
10 empty 2.06 65.7 19.7 No No
6BQF_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.85 68.8 92.7 Yes Yes
2 empty 1.85 63.8 39.7 No No
3 empty 1 69.5 46 No No
4 empty 2.14 51.2 37 No No
5 empty 2.04 68 31.5 No No
6 empty 2.27 63.6 28 No No
7 empty 2.32 58.7 31.2 No No
8 empty 2.13 70.2 31.3 No No
9 empty 2.39 67 21.1 No No
10 empty 2.23 61.6 29 No No
2R7Z_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.71 67.8 104.5 Yes Yes
2 empty 1.02 67.1 51.4 No No
3 empty 1.91 69.6 39.1 No No
4 empty 2.17 64.8 41.8 No No
5 empty 2.11 72.5 28.7 No No
6 empty 2.04 67.6 23.3 No No
7 empty 2.52 66.7 30 No No
8 empty 2.5 74.2 23.5 No No
9 empty 2.19 68.1 24.2 No No
10 empty 1.81 65.1 17.1 No No
2JA7_M DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.02 67.5 104.2 Yes Yes
2 empty .96 67.6 53.5 No No
3 empty 2.19 71.6 39.4 No No
4 empty 2.35 63.3 29 No No
5 empty 2.13 72 31.4 No No
6 empty 2.07 64.1 34.7 No No
7 empty 2.42 64.4 34.1 No No
8 empty 2.18 68.9 22.8 No No
9 empty 2.25 69 25 No No
10 empty 2.28 61.9 19.9 No No
3GTQ_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.92 68.6 85.7 Yes Yes
2 empty 1.37 71.2 66.1 No No
3 empty 1.1 66.1 43.4 No No
4 empty 2.14 55.5 51.7 No No
5 empty 2.3 68.6 38.4 No No
6 empty 1.84 57.9 34.1 No No
7 empty 2.26 62.7 29.6 No No
8 empty 2.11 66.2 34.4 No No
9 empty 2.06 80.6 28.4 No No
10 empty 2 67.4 19.7 No No
5VVR_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.04 70.4 109.3 Yes Yes
2 empty 1.95 67.8 38.5 No No
3 empty 1.68 66.3 30 No No
4 empty 2.09 66.5 37.5 No No
5 empty 2.03 65.4 36.4 No No
6 empty 1.89 67.7 35.9 No No
7 empty 1.8 60.8 31.6 No No
8 empty 2.06 62.5 26.8 No No
9 empty 2.34 62.7 20.9 No No
10 empty 1.65 69.4 17.7 No No
3PO2_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.43 67.8 60.7 Yes Yes
2 bound 1.52 68.7 51.4 No No
3 empty 2 63.9 45.1 No No
4 empty .99 62.9 46.8 No No
5 empty 1.77 60.4 40.9 No No
6 empty 1.92 70.4 33.1 No No
7 empty 1.95 71.2 29.5 No No
8 empty 2.02 66.2 29.4 No No
9 empty 2.03 68 20.9 No No
10 empty 2.31 48.6 31.1 No No
5IP7_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.27 68.9 92 Yes Yes
2 empty .99 67.6 47.1 No No
3 empty 1.9 69.2 35.9 No No
4 empty 1.92 63.4 40 No No
5 empty 1.82 71 30.5 No No
6 empty 2.34 52.4 30.2 No No
7 empty 2.45 70.6 30.2 No No
8 empty 2.12 69.5 32.3 No No
9 empty 1.98 66 29.6 No No
10 empty 2.18 64 36 No No
2NVX_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.03 68.9 103.5 Yes Yes
2 empty 2.49 66.9 55.4 No No
3 empty 2.03 66.3 37.6 No No
4 empty .88 68.1 44.4 No No
5 empty 2.22 50.3 32.7 No No
6 empty 2.13 65.4 37.9 No No
7 empty 2.22 67.6 33.4 No No
8 empty 2.42 66.7 25.5 No No
9 empty 2.31 63.2 27.8 No No
10 empty 2.04 68.8 23 No No
3HOW_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.36 67.6 103.9 Yes Yes
2 empty 1.91 68 40.7 No No
3 empty 1.09 69.2 44.6 No No
4 empty 2.05 65 48.3 No No
5 empty 1.98 65.3 32.2 No No
6 empty 2.15 62.5 23.3 No No
7 empty 2.24 67.2 24.5 No No
8 empty 2.39 61.7 26.2 No No
9 empty 2.03 60.7 23.8 No No
10 empty 2.3 62.4 19.4 No No
2E2J_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.52 69.5 98.9 Yes Yes
2 empty .84 68.9 54.9 No No
3 empty 1.88 62.9 37.8 No No
4 empty 2.29 52.8 31.2 No No
5 empty 2.44 62.8 32.4 No No
6 empty 2.24 66 35.3 No No
7 empty 2.36 65.5 33 No No
8 empty 2.29 49.9 20.3 No No
9 empty 2.23 65.5 34.8 No No
10 empty 2.12 67 22 No No
4A3F_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.31 68.9 71.9 Yes Yes
2 empty 1.7 67.4 70.2 No No
3 bound 1.97 67.2 37.3 No No
4 empty 2.31 62.4 33.2 No No
5 empty 1.03 62.7 45.9 No No
6 empty 1.85 62.6 31.3 No No
7 empty 1.83 72.9 26.8 No No
8 empty 2.05 66.8 34.2 No No
9 empty 1.87 62.5 30.1 No No
10 empty 2.35 49.7 33 No No
3S1N_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.45 68.7 95.2 Yes Yes
2 empty 2.2 66.8 38.2 No No
3 empty 1.88 70.9 33.1 No No
4 empty 2.39 50.4 31.3 No No
5 empty 2.63 61.5 28.4 No No
6 empty 2.02 68.7 35 No No
7 empty 2.04 65.8 32.2 No No
8 empty 2.21 59.8 26.2 No No
9 empty 2.28 51.2 19.6 No No
10 empty 2.04 62.4 29.3 No No
5OT2_A DNA-directed RNA polymerase II subunit RPB1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2 67.6 90.1 Yes Yes
2 empty 1.46 69.4 66.3 No No
3 empty .98 65.7 49.3 No No
4 empty 1.95 70.5 31.8 No No
5 empty 2.34 55 30.7 No No
6 empty 2.19 60.9 38.7 No No
7 empty 2.12 69.9 34.3 No No
8 empty 1.97 66 26.5 No No
9 empty 2.11 64.8 33.4 No No
10 empty 2.45 61.7 23.4 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed78
Domains assessed as druggable using the strict criteria63
Domains assessed as druggable using the relaxed criteria78

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
1I3Q_A (61607) DNA-directed RNA polymerase II subunit RPB1 beta and beta-prime subunits of DNA dependent RNA-polymerase, beta and beta-prime subunits of DNA dependent RNA-polymerase, RNA-polymerase beta-prime 3.1Å Yes Yes
1I50_A (61754) DNA-directed RNA polymerase II subunit RPB1 beta and beta-prime subunits of DNA dependent RNA-polymerase, beta and beta-prime subunits of DNA dependent RNA-polymerase, RNA-polymerase beta-prime 2.8Å Yes Yes
1I6H_A (61831) DNA-directed RNA polymerase II subunit RPB1 beta and beta-prime subunits of DNA dependent RNA-polymerase, beta and beta-prime subunits of DNA dependent RNA-polymerase, RNA-polymerase beta-prime 3.3Å Yes Yes
1K83_A (68275) DNA-directed RNA polymerase II subunit RPB1 beta and beta-prime subunits of DNA dependent RNA-polymerase, beta and beta-prime subunits of DNA dependent RNA-polymerase, RNA-polymerase beta-prime 2.8Å Yes Yes
1NIK_A (85743) DNA-directed RNA polymerase II subunit RPB1 RNA polymerase, RNA polymerase, RNA polymerase 4.1Å Yes Yes
1R5U_A (97105) DNA-directed RNA polymerase II subunit RPB1 RNA polymerase, RNA polymerase, RNA polymerase 4.5Å Yes Yes
1R9S_A (111729) DNA-directed RNA polymerase II subunit RPB1 RNA polymerase, RNA polymerase, RNA polymerase 4.25Å Yes No
1R9T_A (111739) DNA-directed RNA polymerase II subunit RPB1 RNA polymerase, RNA polymerase, RNA polymerase 3.5Å Yes Yes
1SFO_A (98834) DNA-directed RNA polymerase II subunit RPB1 RNA polymerase, RNA polymerase, RNA polymerase 3.6Å Yes Yes
1TWA_A (112696) DNA-directed RNA polymerase II subunit RPB1 beta and beta-prime subunits of DNA dependent RNA-polymerase, beta and beta-prime subunits of DNA dependent RNA-polymerase, RNA-polymerase beta-prime 3.1Å Yes Yes
1TWC_A (112711) DNA-directed RNA polymerase II subunit RPB1 beta and beta-prime subunits of DNA dependent RNA-polymerase, beta and beta-prime subunits of DNA dependent RNA-polymerase, RNA-polymerase beta-prime 3Å Yes Yes
1TWF_A (112725) DNA-directed RNA polymerase II subunit RPB1 beta and beta-prime subunits of DNA dependent RNA-polymerase, beta and beta-prime subunits of DNA dependent RNA-polymerase, RNA-polymerase beta-prime 2.3Å Yes Yes
1TWG_A (112738) DNA-directed RNA polymerase II subunit RPB1 beta and beta-prime subunits of DNA dependent RNA-polymerase, beta and beta-prime subunits of DNA dependent RNA-polymerase, RNA-polymerase beta-prime 3.3Å Yes Yes
1TWH_A (112751) DNA-directed RNA polymerase II subunit RPB1 beta and beta-prime subunits of DNA dependent RNA-polymerase, beta and beta-prime subunits of DNA dependent RNA-polymerase, RNA-polymerase beta-prime 3.4Å Yes Yes
1WCM_A (114510) DNA-directed RNA polymerase II subunit RPB1 RNA polymerase, RNA polymerase, RNA polymerase 3.8Å Yes Yes
1Y1V_A (116349) DNA-directed RNA polymerase II subunit RPB1 RNA polymerase, RNA polymerase, RNA polymerase 3.8Å Yes Yes
1Y1W_A (116362) DNA-directed RNA polymerase II subunit RPB1 RNA polymerase, RNA polymerase, RNA polymerase 4Å Yes Yes
1Y77_A (116512) DNA-directed RNA polymerase II subunit RPB1 RNA polymerase, RNA polymerase, RNA polymerase 4.5Å Yes Yes
2B63_A (127917) DNA-directed RNA polymerase II subunit RPB1 beta and beta-prime subunits of DNA dependent RNA-polymerase, beta and beta-prime subunits of DNA dependent RNA-polymerase, RNA-polymerase beta-prime 3.8Å Yes Yes
2B8K_A (128076) DNA-directed RNA polymerase II subunit RPB1 beta and beta-prime subunits of DNA dependent RNA-polymerase, beta and beta-prime subunits of DNA dependent RNA-polymerase, RNA-polymerase beta-prime 4.15Å Yes Yes
2E2H_A (131981) DNA-directed RNA polymerase II subunit RPB1 beta and beta-prime subunits of DNA dependent RNA-polymerase, beta and beta-prime subunits of DNA dependent RNA-polymerase, RNA-polymerase beta-prime 3.95Å Yes Yes
2E2I_A (131994) DNA-directed RNA polymerase II subunit RPB1 beta and beta-prime subunits of DNA dependent RNA-polymerase, beta and beta-prime subunits of DNA dependent RNA-polymerase, RNA-polymerase beta-prime 3.4Å Yes No
2E2J_A (132007) DNA-directed RNA polymerase II subunit RPB1 beta and beta-prime subunits of DNA dependent RNA-polymerase, beta and beta-prime subunits of DNA dependent RNA-polymerase, RNA-polymerase beta-prime 3.5Å Yes No
2JA5_A (138158) DNA-directed RNA polymerase II subunit RPB1 beta and beta-prime subunits of DNA dependent RNA-polymerase, beta and beta-prime subunits of DNA dependent RNA-polymerase, RNA-polymerase beta-prime 3.8Å Yes Yes
2JA6_A (138174) DNA-directed RNA polymerase II subunit RPB1 beta and beta-prime subunits of DNA dependent RNA-polymerase, beta and beta-prime subunits of DNA dependent RNA-polymerase, RNA-polymerase beta-prime 4Å Yes Yes
2JA7_A (138190) DNA-directed RNA polymerase II subunit RPB1 beta and beta-prime subunits of DNA dependent RNA-polymerase, beta and beta-prime subunits of DNA dependent RNA-polymerase, RNA-polymerase beta-prime 3.8Å Yes No
2JA7_M (138206) DNA-directed RNA polymerase II subunit RPB1 beta and beta-prime subunits of DNA dependent RNA-polymerase, beta and beta-prime subunits of DNA dependent RNA-polymerase, RNA-polymerase beta-prime 3.8Å Yes No
2JA8_A (138222) DNA-directed RNA polymerase II subunit RPB1 beta and beta-prime subunits of DNA dependent RNA-polymerase, beta and beta-prime subunits of DNA dependent RNA-polymerase, RNA-polymerase beta-prime 3.8Å Yes No
2NVQ_A (138634) DNA-directed RNA polymerase II subunit RPB1 beta and beta-prime subunits of DNA dependent RNA-polymerase, beta and beta-prime subunits of DNA dependent RNA-polymerase, RNA-polymerase beta-prime 2.9Å Yes Yes
2NVT_A (138647) DNA-directed RNA polymerase II subunit RPB1 beta and beta-prime subunits of DNA dependent RNA-polymerase, beta and beta-prime subunits of DNA dependent RNA-polymerase, RNA-polymerase beta-prime 3.36Å Yes Yes
2NVX_A (138667) DNA-directed RNA polymerase II subunit RPB1 beta and beta-prime subunits of DNA dependent RNA-polymerase, beta and beta-prime subunits of DNA dependent RNA-polymerase, RNA-polymerase beta-prime 3.6Å Yes Yes
2NVY_A (138680) DNA-directed RNA polymerase II subunit RPB1 beta and beta-prime subunits of DNA dependent RNA-polymerase, beta and beta-prime subunits of DNA dependent RNA-polymerase, RNA-polymerase beta-prime 3.4Å Yes Yes
2NVZ_A (138693) DNA-directed RNA polymerase II subunit RPB1 beta and beta-prime subunits of DNA dependent RNA-polymerase, beta and beta-prime subunits of DNA dependent RNA-polymerase, RNA-polymerase beta-prime 4.2Å Yes Yes
2R7Z_A (151658) DNA-directed RNA polymerase II subunit RPB1 RNA polymerase, RNA polymerase, RNA polymerase 3.8Å Yes Yes
2R92_A (151745) DNA-directed RNA polymerase II subunit RPB1 RNA polymerase, RNA polymerase, RNA polymerase 3.8Å Yes Yes
2R93_A (151754) DNA-directed RNA polymerase II subunit RPB1 RNA polymerase, RNA polymerase, RNA polymerase 4Å Yes Yes
2VUM_A (153548) DNA-directed RNA polymerase II subunit RPB1 RNA polymerase, RNA polymerase, RNA polymerase 3.4Å Yes No
2YU9_A (140064) DNA-directed RNA polymerase II subunit RPB1 beta and beta-prime subunits of DNA dependent RNA-polymerase, beta and beta-prime subunits of DNA dependent RNA-polymerase, RNA-polymerase beta-prime 3.4Å Yes Yes
3CQZ_A (156929) DNA-directed RNA polymerase II subunit RPB1 RNA polymerase, RNA polymerase, RNA polymerase 2.8Å Yes No
3FKI_A (3410379) DNA-directed RNA polymerase II subunit RPB1 beta and beta-prime subunits of DNA dependent RNA-polymerase, beta and beta-prime subunits of DNA dependent RNA-polymerase, UNMATCHED 3.8Å Yes Yes
3GTG_A (3440254) DNA-directed RNA polymerase II subunit RPB1 beta and beta-prime subunits of DNA dependent RNA-polymerase, beta and beta-prime subunits of DNA dependent RNA-polymerase, UNMATCHED 3.78Å Yes Yes
3GTJ_A (3440282) DNA-directed RNA polymerase II subunit RPB1 beta and beta-prime subunits of DNA dependent RNA-polymerase, beta and beta-prime subunits of DNA dependent RNA-polymerase, UNMATCHED 3.4Å Yes Yes
3GTK_A (3440307) DNA-directed RNA polymerase II subunit RPB1 beta and beta-prime subunits of DNA dependent RNA-polymerase, beta and beta-prime subunits of DNA dependent RNA-polymerase, UNMATCHED 3.8Å Yes Yes
3GTL_A (3440332) DNA-directed RNA polymerase II subunit RPB1 beta and beta-prime subunits of DNA dependent RNA-polymerase, beta and beta-prime subunits of DNA dependent RNA-polymerase, UNMATCHED 3.38Å Yes Yes
3GTM_A (3440357) DNA-directed RNA polymerase II subunit RPB1 beta and beta-prime subunits of DNA dependent RNA-polymerase, beta and beta-prime subunits of DNA dependent RNA-polymerase, UNMATCHED 3.8Å Yes Yes
3GTO_A (3440387) DNA-directed RNA polymerase II subunit RPB1 beta and beta-prime subunits of DNA dependent RNA-polymerase, beta and beta-prime subunits of DNA dependent RNA-polymerase, UNMATCHED 4Å Yes Yes
3GTP_A (3440412) DNA-directed RNA polymerase II subunit RPB1 beta and beta-prime subunits of DNA dependent RNA-polymerase, beta and beta-prime subunits of DNA dependent RNA-polymerase, UNMATCHED 3.9Å Yes Yes
3GTQ_A (3440437) DNA-directed RNA polymerase II subunit RPB1 beta and beta-prime subunits of DNA dependent RNA-polymerase, beta and beta-prime subunits of DNA dependent RNA-polymerase, UNMATCHED 3.8Å Yes Yes
3H3V_B (3450145) DNA-directed RNA polymerase II subunit RPB1 beta and beta-prime subunits of DNA dependent RNA-polymerase, beta and beta-prime subunits of DNA dependent RNA-polymerase, UNMATCHED 4Å Yes Yes
3HOU_A (4003650) DNA-directed RNA polymerase II subunit RPB1 beta and beta-prime subunits of DNA dependent RNA-polymerase, beta and beta-prime subunits of DNA dependent RNA-polymerase, RNA-polymerase beta-prime 3.2Å Yes Yes
3HOU_M (4220673) DNA-directed RNA polymerase II subunit RPB1 beta and beta-prime subunits of DNA dependent RNA-polymerase, beta and beta-prime subunits of DNA dependent RNA-polymerase, RNA-polymerase beta-prime 3.2Å Yes Yes
3HOV_A (4062945) DNA-directed RNA polymerase II subunit RPB1 beta and beta-prime subunits of DNA dependent RNA-polymerase, beta and beta-prime subunits of DNA dependent RNA-polymerase, RNA-polymerase beta-prime 3.5Å Yes Yes
3HOW_A (4177266) DNA-directed RNA polymerase II subunit RPB1 beta and beta-prime subunits of DNA dependent RNA-polymerase, beta and beta-prime subunits of DNA dependent RNA-polymerase, RNA-polymerase beta-prime 3.6Å Yes Yes
3HOX_A (4046406) DNA-directed RNA polymerase II subunit RPB1 beta and beta-prime subunits of DNA dependent RNA-polymerase, beta and beta-prime subunits of DNA dependent RNA-polymerase, RNA-polymerase beta-prime 3.65Å Yes Yes
3HOY_A (4227559) DNA-directed RNA polymerase II subunit RPB1 beta and beta-prime subunits of DNA dependent RNA-polymerase, beta and beta-prime subunits of DNA dependent RNA-polymerase, RNA-polymerase beta-prime 3.4Å Yes No
3HOZ_A (4235479) DNA-directed RNA polymerase II subunit RPB1 beta and beta-prime subunits of DNA dependent RNA-polymerase, beta and beta-prime subunits of DNA dependent RNA-polymerase, RNA-polymerase beta-prime 3.65Å Yes Yes
3I4M_A (4243404) DNA-directed RNA polymerase II subunit RPB1 beta and beta-prime subunits of DNA dependent RNA-polymerase, beta and beta-prime subunits of DNA dependent RNA-polymerase, RNA-polymerase beta-prime 3.7Å Yes No
3I4N_A (4224687) DNA-directed RNA polymerase II subunit RPB1 beta and beta-prime subunits of DNA dependent RNA-polymerase, beta and beta-prime subunits of DNA dependent RNA-polymerase, RNA-polymerase beta-prime 3.9Å Yes No
3K1F_A (3490596) DNA-directed RNA polymerase II subunit RPB1 beta and beta-prime subunits of DNA dependent RNA-polymerase, beta and beta-prime subunits of DNA dependent RNA-polymerase, UNMATCHED 4.3Å Yes Yes
3K7A_A (3490996) DNA-directed RNA polymerase II subunit RPB1 beta and beta-prime subunits of DNA dependent RNA-polymerase, beta and beta-prime subunits of DNA dependent RNA-polymerase, UNMATCHED 3.8Å Yes Yes
3M3Y_A (3540474) DNA-directed RNA polymerase II subunit RPB1 beta and beta-prime subunits of DNA dependent RNA-polymerase, beta and beta-prime subunits of DNA dependent RNA-polymerase, UNMATCHED 3.18Å Yes Yes
3M4O_A (3540521) DNA-directed RNA polymerase II subunit RPB1 beta and beta-prime subunits of DNA dependent RNA-polymerase, beta and beta-prime subunits of DNA dependent RNA-polymerase, UNMATCHED 3.57Å Yes Yes
3PO2_A (3670453) DNA-directed RNA polymerase II subunit RPB1 beta and beta-prime subunits of DNA dependent RNA-polymerase, beta and beta-prime subunits of DNA dependent RNA-polymerase, UNMATCHED 3.3Å Yes Yes
3PO3_A (3670477) DNA-directed RNA polymerase II subunit RPB1 beta and beta-prime subunits of DNA dependent RNA-polymerase, beta and beta-prime subunits of DNA dependent RNA-polymerase, UNMATCHED 3.3Å Yes No
3QT1_A (3690441) DNA-directed RNA polymerase II subunit RPB1 beta and beta-prime subunits of DNA dependent RNA-polymerase, beta and beta-prime subunits of DNA dependent RNA-polymerase, UNMATCHED 4.3Å Yes Yes
3RZD_A (3700473) DNA-directed RNA polymerase II subunit RPB1 beta and beta-prime subunits of DNA dependent RNA-polymerase, beta and beta-prime subunits of DNA dependent RNA-polymerase, UNMATCHED 3.29Å Yes Yes
3RZO_A (3700497) DNA-directed RNA polymerase II subunit RPB1 beta and beta-prime subunits of DNA dependent RNA-polymerase, beta and beta-prime subunits of DNA dependent RNA-polymerase, UNMATCHED 3Å Yes Yes
3S14_A (3700537) DNA-directed RNA polymerase II subunit RPB1 beta and beta-prime subunits of DNA dependent RNA-polymerase, beta and beta-prime subunits of DNA dependent RNA-polymerase, UNMATCHED 2.84Å Yes Yes
3S15_A (3700557) DNA-directed RNA polymerase II subunit RPB1 beta and beta-prime subunits of DNA dependent RNA-polymerase, beta and beta-prime subunits of DNA dependent RNA-polymerase, UNMATCHED 3.3Å Yes Yes
3S16_A (3700577) DNA-directed RNA polymerase II subunit RPB1 beta and beta-prime subunits of DNA dependent RNA-polymerase, beta and beta-prime subunits of DNA dependent RNA-polymerase, UNMATCHED 3.24Å Yes Yes
3S17_A (3700597) DNA-directed RNA polymerase II subunit RPB1 beta and beta-prime subunits of DNA dependent RNA-polymerase, beta and beta-prime subunits of DNA dependent RNA-polymerase, UNMATCHED 3.17Å Yes Yes
3S1M_A (3700630) DNA-directed RNA polymerase II subunit RPB1 beta and beta-prime subunits of DNA dependent RNA-polymerase, beta and beta-prime subunits of DNA dependent RNA-polymerase, UNMATCHED 3.13Å Yes Yes
3S1N_A (3700650) DNA-directed RNA polymerase II subunit RPB1 beta and beta-prime subunits of DNA dependent RNA-polymerase, beta and beta-prime subunits of DNA dependent RNA-polymerase, UNMATCHED 3.1Å Yes Yes
3S1Q_A (3700670) DNA-directed RNA polymerase II subunit RPB1 beta and beta-prime subunits of DNA dependent RNA-polymerase, beta and beta-prime subunits of DNA dependent RNA-polymerase, UNMATCHED 3.3Å Yes No
3S1R_A (3700690) DNA-directed RNA polymerase II subunit RPB1 beta and beta-prime subunits of DNA dependent RNA-polymerase, beta and beta-prime subunits of DNA dependent RNA-polymerase, UNMATCHED 3.2Å Yes No
3S2D_A (3700734) DNA-directed RNA polymerase II subunit RPB1 beta and beta-prime subunits of DNA dependent RNA-polymerase, beta and beta-prime subunits of DNA dependent RNA-polymerase, UNMATCHED 3.19Å Yes Yes
3S2H_A (3700754) DNA-directed RNA polymerase II subunit RPB1 beta and beta-prime subunits of DNA dependent RNA-polymerase, beta and beta-prime subunits of DNA dependent RNA-polymerase, UNMATCHED 3.29Å Yes Yes
4A3C_A (4258521) DNA-directed RNA polymerase II subunit RPB1 beta and beta-prime subunits of DNA dependent RNA-polymerase, beta and beta-prime subunits of DNA dependent RNA-polymerase, RNA-polymerase beta-prime 3.5Å Yes No
Ligand-based Druggability Score:
Ligand-based Druggability Score Percentile: %
Ligand-based Druggability Help: Help




		
This protein has no network-based druggability score