Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

MMP1 (P03956) - Overview - Molecular Target Synopsis

Protein


MMP1, Interstitial collagenase
Enzyme Classification 3.4.24.7
UniProt P03956

Also Known as MMP1_HUMAN, MMP1, CLG

Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X (PubMed:2557822, PubMed:2153297, PubMed:1645757). In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity (PubMed:16807369). (Microbial infection) Interacts with HIV-1 Tat.

4AUO
CRYSTAL STRUCTURE OF MMP-1(E200A) IN COMPLEX WITH A TRIPLE- HELICAL COLLAGEN PEPTIDE
RCSB/PDB
Inspect Structure
See all 3D Structures for MMP1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
469ENSG00000196611ENST00000315274ENSP00000322788P03956-1

Sub-cellular localization


UniProt: MMP1 is active in the following subcellular-locations: extracellular matrix, extracellular space, secreted.
GO terms: MMP1 is active in the following subcellular-locations: extracellular matrix, extracellular region, extracellular space.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project MMP1 has gain in 13 cell-lines, loss in 6 cell-lines and no signal in 986 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SF_295, NCI_ADR_RES, UO_31

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SK-OV-3, HCC366, Hs 683

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: BJ, IMR-90, NHLF

(see details)

3D Structures


For MMP1 there are:
15 structures (24 chains) solved
7 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


MMP1 has been screened with 5307 compounds (7241 bioactivities), 1289 compounds have bioactivities that show binding affinity of <= 500nM (1692 bioactivities). (see details)