Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ANG (P03950) - Overview - Molecular Target Synopsis

Protein


ANG, Angiogenin
Enzyme Classification 3.1.27.-
UniProt P03950

Also Known as ANGI_HUMAN, ANG, RNASE5

Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo. Homodimer (PubMed:25372031). Interacts with and forms a tight 1:1 complex with RNH1. Dimerization of two such complexes may occur.

5M9G
HUMAN ANGIOGENIN PD VARIANT K54R
RCSB/PDB
Inspect Structure
See all 3D Structures for ANG

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization


UniProt: ANG is active in the following subcellular-locations: cytoplasmic vesicle, nucleolus, nucleus, secreted, secretory vesicle lumen.
GO terms: ANG is active in the following subcellular-locations: angiogenin-PRI complex, basement membrane, cytoplasmic vesicle, extracellular region, extracellular space, growth cone, neuronal cell body, nucleolus, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ANG has gain in 4 cell-lines, loss in 1 cell-lines and no signal in 1000 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: KM12, A549, NCI_H460

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hep G2, COV434, C3A

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HeLa-S3, HUVEC, A549

(see details)

3D Structures


For ANG there are:
45 structures (54 chains) solved
24 are solved in complex with at least one small molecule ligand
9 are solved with an approved drug

ANG is solved in complex with the approved drug(s):

TAR/TARTARIC ACID (4AHG_A, 4AHJ_A, 4AHK_B, 4AOH_A, 5M9A_A, 5M9C_A, 5M9G_A, 5M9R_A, 5M9R_B, 5M9S_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ANG has been screened with 6 compounds (6 bioactivities). (see details)