Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
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Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
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V (P03733) - Overview - Molecular Target Synopsis

Protein


V, Tail tube protein
UniProt P03733

Also Known as TUBE_LAMBD, V

Forms the phage's tail tube composed of 32 hexameric disks. When it encounters the appropriate initiation complex gpM and gpL, it assembles in hexameric rings that stack on top of each others. Multimerization ceases when the correct tail length is achieved through a mechanism dependent on tail terminator protein. Multimerizes into a structure formed by 32 hexameric rings stacked on phage baseplate gpM and gpL. Does not multimerize in solution without the tail initiation complex. Soluble major tail protein interacts with tail assembly protein GT during tail assembly.

2L04
THE SOLUTION STRUCTURE OF THE C-TERMINAL IG-LIKE DOMAIN OF THE BACTERIOPHAGE LAMBDA TAIL TUBE PROTEIN
RCSB/PDB
Inspect Structure
See all 3D Structures for V

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
246P03733-1

Sub-cellular localization


UniProt: V is active in the following subcellular-locations: host cytoplasm, virion.
GO terms: V is active in the following subcellular-locations: host cell cytoplasm, virus tail.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project V has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For V there are:
2 structures (2 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis