Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
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Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
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Germline Genetics

EBNA6 (P03204) - Overview - Molecular Target Synopsis

Protein


EBNA6, Epstein-Barr nuclear antigen 6
UniProt P03204

Also Known as EBNA6_EBVB9, EBNA6

Plays an essential role for the activation and immortalization of human B-cells. Represses transcription of viral promoters TP1 and Cp through interaction with host RBPJ, and inhibits EBNA2-mediated activation of these promoters. Since Cp is the promoter for all EBNA mRNAs, EBNA6 probably contributes to a negative autoregulatory control loop. Alternatively, EBNA6 also regulates the transcription of the EBV oncogene LMP1 in a cell cycle-dependent manner. Modulates the activity of several host proteins involved in cell cycle regulation including host cyclin A, MYC, RB, p21 and p27 mainly through binding to the host SCF(SKP2) complex. Inhibits the promoter of host H2AX and targets H2AX to proteasomal degradation in order to promote latency and cell proliferation. Interacts with host CTPB1; this interaction seems important for EBNA6-mediated transcriptional repression. Interacts with host MYC; this interaction enhances MYC stability. Interacts (via N-terminus) with host RBPJ. Interacts (via N-terminus) with host histone H2AX; this interaction facilitates H2AX proteasomal degradation. Interacts with host TP73; this interaction inhibits TP73-mediated apoptotic pathway.

3DX7
10 RESIDUE FRAGMENT OF
EBV DECAPEPTIDE EPITOPE
IN THE STRUCTURE OF
CRYSTAL STRUCTURE OF HLA-B*4403 PRESENTING 10MER EBV ANTIGEN
RCSB/PDB
Inspect Structure
See all 3D Structures for EBNA6

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
992P03204-1

Sub-cellular localization


UniProt: EBNA6 is active in the following subcellular-locations: host nucleus, host nucleus matrix.
GO terms: EBNA6 is active in the following subcellular-locations: host cell nuclear matrix.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project EBNA6 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For EBNA6 there are:
6 structures (8 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis