Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ALB (P02769) - Overview - Molecular Target Synopsis

Protein


ALB, Serum albumin
UniProt P02769

Also Known as ALBU_BOVIN, ALB

Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.

4OR0
CRYSTAL STRUCTURE OF BOVINE SERUM ALBUMIN IN COMPLEX WITH NAPROXEN
RCSB/PDB
Inspect Structure
See all 3D Structures for ALB

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
607P02769-1

Sub-cellular localization


UniProt: ALB is active in the following subcellular-locations: secreted.
GO terms: ALB is active in the following subcellular-locations: extracellular region, extracellular space, protein-containing complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ALB has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For ALB there are:
5 structures (9 chains) solved
4 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

ALB is solved in complex with the approved drug(s):

NPS/NAPROXEN (4OR0_A, 4OR0_B).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ALB has been screened with 302 compounds (657 bioactivities). (see details)