Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ALB (P02768) - Overview - Molecular Target Synopsis

Protein


ALB, Serum albumin
UniProt P02768

Also Known as ALBU_HUMAN, ALB

Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.

6JE7
CRYSTAL STRUCTURE OF HUMAN SERUM ALBUMIN CRYSTALLIZED BY AMMONIUM SULFATE
RCSB/PDB
Inspect Structure
See all 3D Structures for ALB

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


Gene Copy Number Variation


In COSMIC - Cell Lines Project ALB has gain in 2 cell-lines, loss in 2 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SR, MCF7, SK_OV_3

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: C3A, JHH-7, JHH-5

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HepG2, SK-N-SH, NHLF

(see details)

3D Structures


For ALB there are:
107 structures (160 chains) solved
83 are solved in complex with at least one small molecule ligand
30 are solved with an approved drug

ALB is solved in complex with the approved drug(s):

9SC/ARIPIPRAZOLE (6A7P_A, 6A7P_B),
CLT/PHENYLBUTANOIC ACID (5YOQ_A, 5YOQ_B),
P1Z/PHENYLBUTAZONE (2BXC_A, 2BXC_B, 2BXP_A, 2BXQ_A),
IMN/INDOMETHACIN (2BXK_A, 2BXM_A, 2BXQ_A),
T44/LEVOTHYROXINE (1HK1_A, 1HK2_A, 1HK3_A, 1HK4_A, 1HK5_A),
LQZ/LIDOCAINE (3JQZ_A),
IBP/DEXIBUPROFEN (2BXG_A, 2BXG_B),
IDB/IODIPAMIDE (2BXN_A),
DIF/DICLOFENAC (4Z69_A, 4Z69_I),
1FL/DIFLUNISAL (2BXE_A, 2BXE_B),
DZP/DIAZEPAM (2BXF_A, 2BXF_B),
TRP/TRYPTOPHAN (5Z0B_A, 5Z0B_B, 5Z0B_C),
DM5/IDARUBICIN (4LB2_A, 4LB2_B),
AZZ/ZIDOVUDINE (3B9L_A, 3B9M_A),
EVP/ETOPOSIDE (4LB9_A),
9TP/TENIPOSIDE (4L9Q_A, 4L9Q_B),
PFL/PROPOFOL (1E7A_A, 1E7A_B),
FUA/FUSIDIC ACID (2VUF_A, 2VUF_B),
SAL/SALICYLIC ACID (2I2Z_A, 2I30_A, 3B9M_A),
FRU/FRUCTOSE (4IW1_A),
NPS/NAPROXEN (2VDB_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ALB has been screened with 1019 compounds (1790 bioactivities), 9 compounds have bioactivities that show binding affinity of <= 500nM (9 bioactivities). (see details)