Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ORM1 (P02763) - Overview - Molecular Target Synopsis

Protein


ORM1, Alpha-1-acid glycoprotein 1
UniProt P02763

Also Known as A1AG1_HUMAN, ORM1, AGP1

Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in the body. Appears to function in modulating the activity of the immune system during the acute-phase reaction.

3KQ0
CRYSTAL STRUCTURE OF HUMAN ALPHA1-ACID GLYCOPROTEIN
RCSB/PDB
Inspect Structure
See all 3D Structures for ORM1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
212ENSG00000229314ENST00000538816ENSP00000442679
201ENSG00000229314ENST00000259396ENSP00000259396
201P02763-1

Sub-cellular localization


Gene Copy Number Variation


In COSMIC - Cell Lines Project ORM1 has gain in 0 cell-lines, loss in 1 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MCF7, M14, HL_60

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: JHH-5, C3A, Hep G2

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HepG2, SK-N-SH, NHLF

(see details)

RNA Interference


ORM1 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: . (see details)

3D Structures


For ORM1 there are:
1 structures (1 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ORM1 has been screened with 12 compounds (13 bioactivities). (see details)